prikaz prve stranice dokumenta Impact of pentadecapeptide BPC 157 on muscle healing impaired by systemic corticosteroid application
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Scientific paper - Original scientific paper
Impact of pentadecapeptide BPC 157 on muscle healing impaired by systemic corticosteroid application
Medical science monitor, 16 (2010), 3; 81-88. urn:nbn:hr:264:547766
Pevec, Damira; Novinščak, Tomislac; Brčić, Luka; Šipoš, Kristijan; Jukić, Ivana; Starešinić, Mario; Miše, Stjepan; Brčić, Iva; Kolenc, Danijela; Kliček, Robert; Banić, Tihomir; Sever, Marko; Kocijan, Ana; Berkopić, Lidija; Radić, Božo; Buljat, Gojko; Anić, Tomislav; Zoričić, Ivan; Bojanić, Ivan; Seiwerth, Sven; Sikirić, Predrag More authors...

Institutional repository: Merkur University Hospital Repository

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Pevec, D., Novinščak, T., Brčić, L., Šipoš, K., Jukić, I., Starešinić, M. ... Sikirić, P. (2010). Impact of pentadecapeptide BPC 157 on muscle healing impaired by systemic corticosteroid application. Medical science monitor, 16. (3), 81-88. Retrieved from https://urn.nsk.hr/urn:nbn:hr:264:547766

Pevec, Damira, et al. "Impact of pentadecapeptide BPC 157 on muscle healing impaired by systemic corticosteroid application." Medical science monitor, vol. 16, no. 3, 2010, pp. 81-88. https://urn.nsk.hr/urn:nbn:hr:264:547766

Pevec, Damira, Tomislac Novinščak, Luka Brčić, Kristijan Šipoš, Ivana Jukić, Mario Starešinić, Stjepan Miše, et al. "Impact of pentadecapeptide BPC 157 on muscle healing impaired by systemic corticosteroid application." Medical science monitor 16, no. 3 (2010): 81-88. https://urn.nsk.hr/urn:nbn:hr:264:547766

Pevec, D., et al. (2010) 'Impact of pentadecapeptide BPC 157 on muscle healing impaired by systemic corticosteroid application', Medical science monitor, 16(3), pp. 81-88. Available at: https://urn.nsk.hr/urn:nbn:hr:264:547766 (Accessed 22 November 2024)

Pevec D, Novinščak T, Brčić L, Šipoš K, Jukić I, Starešinić M, and sur.. Impact of pentadecapeptide BPC 157 on muscle healing impaired by systemic corticosteroid application. Medical science monitor [Internet]. 2010 [cited 2024 November 22];16(3):81-88. Available at: https://urn.nsk.hr/urn:nbn:hr:264:547766

D. Pevec, et al., "Impact of pentadecapeptide BPC 157 on muscle healing impaired by systemic corticosteroid application", Medical science monitor, vol. 16, no. 3, pp. 81-88, 2010. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:264:547766. [Accessed: 22 November 2024]

Metadata
Title (english)Impact of pentadecapeptide BPC 157 on muscle healing impaired by systemic corticosteroid application
AuthorDamira Pevec
AuthorTomislac Novinščak
AuthorLuka Brčić
MBZ: 272221
AuthorKristijan Šipoš
AuthorIvana Jukić
AuthorMario Starešinić
AuthorStjepan Miše
MBZ: 102751
AuthorIva Brčić
MBZ: 296400
AuthorDanijela Kolenc
MBZ: 272116
AuthorRobert Kliček
AuthorTihomir Banić
AuthorMarko Sever
MBZ: 331893
AuthorAna Kocijan
AuthorLidija Berkopić
AuthorBožo Radić
AuthorGojko Buljat
MBZ: 38583
AuthorTomislav Anić
MBZ: 158823
AuthorIvan Zoričić
MBZ: 178566
AuthorIvan Bojanić
MBZ: 171746
AuthorSven Seiwerth
MBZ: 149676
AuthorPredrag Sikirić
MBZ: 117454
Author's institution(Merkur University Hospital)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
The effect of systemic and local peptide treatment effective in muscle contusion and then on counteraction of corticosteroid-induced impairment was tested. The pentadecapeptide BPC 157, given without a carrier, improved the healing of transected quadriceps muscle. It also improved muscle healing in rats with muscle crush injury when applied systemically or locally. Importantly, it counteracted corticosteroid-impairment in tendon to bone healing. Thus BPC 157 is proposed as an effective treatment that can improve muscle healing in spite of corticosteroid treatment. After the gastrocnemius muscle complex had been injured, rats received BPC 157 (intraperitoneally or locally as a cream) and/or 6alpha-methylprednisolone (intraperitoneally) only once (immediately after injury, sacrifice at 2 h) or once daily (final dose 24 hours before sacrifice and/or assessment procedure at days 1, 2, 4, 7, and 14). Muscle healing was evaluated functionally, macroscopically, and histologically. Without therapy, crushed gastrocnemius muscle complex controls showed limited improvement. 6alpha-methylprednisolone markedly aggravated healing. In contrast, BPC 157 induced faster muscle healing and full function restoration and improved muscle healing despite systemic corticosteroid treatment when given intraperitoneally or locally and demonstrated functionally, macroscopically, and histologically at all investigated intervals. BPC 157 completely reversed systemic corticosteroid-impaired muscle healing.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleMedical science monitor
Numberingvol. 16, no. 3, pp. 81-88
p-ISSN1234-1010
URN:NBNurn:nbn:hr:264:547766
Publication2010
Document URLhttps://medscimonit.com/abstract/index/idArt/878454
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2022-12-27 11:22:19