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Scientific paper - Original scientific paper
Methods Used for Enhancing the Bioavailability of Oral Curcumin in Randomized Controlled Trials : A Meta-Research Study
Pharmaceuticals, 15 (2022), 8; 939. https://doi.org/10.3390/ph15080939
Mimica, Bruna; Bučevic Popović, Viljemka; Banjari, Ines; Jeličić Kadić, Antonia; Puljak, Livia

Institutional repository: University Hospital of Split Digital Repository

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Mimica, B., Bučevic Popović, V., Banjari, I., Jeličić Kadić, A. & Puljak, L. (2022). Methods Used for Enhancing the Bioavailability of Oral Curcumin in Randomized Controlled Trials : A Meta-Research Study. Pharmaceuticals, 15. (8). doi: 10.3390/ph15080939

Mimica, Bruna, et al. "Methods Used for Enhancing the Bioavailability of Oral Curcumin in Randomized Controlled Trials : A Meta-Research Study." Pharmaceuticals, vol. 15, no. 8, 2022. https://doi.org/10.3390/ph15080939

Mimica, Bruna, Viljemka Bučevic Popović, Ines Banjari, Antonia Jeličić Kadić and Livia Puljak. "Methods Used for Enhancing the Bioavailability of Oral Curcumin in Randomized Controlled Trials : A Meta-Research Study." Pharmaceuticals 15, no. 8 (2022). https://doi.org/10.3390/ph15080939

Mimica, B., et al. (2022) 'Methods Used for Enhancing the Bioavailability of Oral Curcumin in Randomized Controlled Trials : A Meta-Research Study', Pharmaceuticals, 15(8). doi: 10.3390/ph15080939

Mimica B, Bučevic Popović V, Banjari I, Jeličić Kadić A, Puljak L. Methods Used for Enhancing the Bioavailability of Oral Curcumin in Randomized Controlled Trials : A Meta-Research Study. Pharmaceuticals [Internet]. 2022 [cited 2024 December 27];15(8). doi: 10.3390/ph15080939

B. Mimica, V. Bučevic Popović, I. Banjari, A. Jeličić Kadić and L. Puljak, "Methods Used for Enhancing the Bioavailability of Oral Curcumin in Randomized Controlled Trials : A Meta-Research Study", Pharmaceuticals, vol. 15, no. 8, 2022. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:266:510274. [Accessed: 27 December 2024]

Metadata
Title (english)Methods Used for Enhancing the Bioavailability of Oral Curcumin in Randomized Controlled Trials : A Meta-Research Study
AuthorBruna Mimica https://orcid.org/0000-0001-9708-0673
AuthorViljemka Bučevic Popović https://orcid.org/0000-0001-9927-1107
AuthorInes Banjari https://orcid.org/0000-0002-8680-5007
AuthorAntonia Jeličić Kadić https://orcid.org/0000-0002-1873-960X
AuthorLivia Puljak
Author's institution(University Hospital of Split)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Pharmacy
Abstract (english)
It is unknown how randomized controlled trials (RCTs) approach the problem related to curcumin bioavailability. We analyzed methods and reporting regarding the bioavailability of systemic oral curcumin used in RCTs. We searched PubMed on 12 September 2020, to find articles reporting RCTs that used curcumin as an intervention. We extracted data about trial characteristics, curcumin products used, methods for improving curcumin bioavailability, and mentions of curcumin bioavailability. We included 165 RCTs. The most common category of intervention was simply described as "curcumin" or "curcuminoids" without a commercial name. There were 107 (64%) manuscripts that reported that they used methods to enhance the oral bioavailability of curcuminoids used in their intervention; 25 different methods were reported. The most common method was the addition of piperine (23%). Phospholipidated curcumin, a combination of curcumin and turmeric oils, nanomicellar curcumin, and colloidal dispersion of curcumin were the next most common methods. Fourteen trials (8.4%) compared more than one different curcumin product; nine (7.9%) trials compared the bioavailability/pharmacokinetics of curcumin products. In conclusion, a high number of diverse methods were used, and very few trials compared different curcumin products. More studies are needed to explore the comparative bioavailability and efficacy of different curcumin products.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titlePharmaceuticals
Numberingvol. 15, no. 8, 939
e-ISSN1424-8247
DOIhttps://doi.org/10.3390/ph15080939
URN:NBNurn:nbn:hr:266:510274
Publication2022
Document URLhttps://www.mdpi.com/1424-8247/15/8/939/pdf?version=1659695522
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2022-09-08 13:20:53