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undergraduate thesis
Kemija vitamina B6 i sinteza novih analoga vitamina B6
Osijek: Josip Juraj Strossmayer University of Osijek, Department of Chemistry, 2016. urn:nbn:hr:182:552557
Živković, Ivana
Josip Juraj Strossmayer University of Osijek
Department of Chemistry
Department of Analytical, Organic and Applied Chemistry

Institutional repository: Repository of the Department of Chemistry, Osijek

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Živković, I. (2016). Kemija vitamina B6 i sinteza novih analoga vitamina B6 (Undergraduate thesis). Osijek: Josip Juraj Strossmayer University of Osijek, Department of Chemistry. Retrieved from https://urn.nsk.hr/urn:nbn:hr:182:552557

Živković, Ivana. "Kemija vitamina B6 i sinteza novih analoga vitamina B6." Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, 2016. https://urn.nsk.hr/urn:nbn:hr:182:552557

Živković, Ivana. "Kemija vitamina B6 i sinteza novih analoga vitamina B6." Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, 2016. https://urn.nsk.hr/urn:nbn:hr:182:552557

Živković, I. (2016). 'Kemija vitamina B6 i sinteza novih analoga vitamina B6', Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, accessed 26 November 2024, https://urn.nsk.hr/urn:nbn:hr:182:552557

Živković I. Kemija vitamina B6 i sinteza novih analoga vitamina B6 [Undergraduate thesis]. Osijek: Josip Juraj Strossmayer University of Osijek, Department of Chemistry; 2016 [cited 2024 November 26] Available at: https://urn.nsk.hr/urn:nbn:hr:182:552557

I. Živković, "Kemija vitamina B6 i sinteza novih analoga vitamina B6", Undergraduate thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, Osijek, 2016. Available at: https://urn.nsk.hr/urn:nbn:hr:182:552557

Metadata
TitleKemija vitamina B6 i sinteza novih analoga vitamina B6
Title (english)The chemistry of vitamin B6 and synthesis of novel analogues of vitamin B6
AuthorIvana Živković
MentorDean Marković (mentor)
MentorDajana Gašo-Sokač (mentor)
GranterJosip Juraj Strossmayer University of Osijek
Department of Chemistry
(Department of Analytical, Organic and Applied Chemistry)
Osijek
Defense date and country2016-09-20, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Analytic Chemistry
Abstract
Vitamin B6 je generički naziv za skupinu od šest spojeva: piridoksin, piridoksal piridoksamin i njihove 5'-fosfate odnosno 3-hidroksi-2-metil-5-hidroksimetil piridinske derivate. Prva totalna sinteza vitamina B6 je provedena kondenzacijom 1-etoksipentan-2,4-diona i cijanacetamida. Svim živim bićima potreban je vitamin B6 za opstanak. Međutim, samo su mikroorganizmi i biljke sposobni sintetizirati ga de novo. Uloga vitamina B6 je vezana uz brojne metaboličke procese, te također ima ulogu i kao kofaktor u nekim enzimski kataliziranim reakcijama. Vitamin B6 je esencijalan za više od 100 enzima koji su uključeni u sintezu proteina. Najviše je proučavana koenzimatska aktivnost piridoksal-5'-fosfata (PLP), PLP-ovisni enzimi su uključeni u važne korake metabolizma aminokiselina, procesima dekarboksilacije i racemizacije, formiranja hemoglobina i biosintezi klorofila. Vitamin B6 bi mogao imati ulogu u sprečavanju oksidativnog stresa stanica. Manjak vitamina B6 u ljudskoj prehrani uključuje niz posljedica, odnosno nastanka bolesti, ozbiljnih i manje ozbiljnih kao npr. hiperhomocistein anemija i povećan rizik za artelosklerozu.
Abstract (english)
Vitamin B6 exists in three basic chemical forms: pyridoxine (an alcohol), pyridoxal (an aldehyde) and pyridoxamine (a primary amine). The three major forms can be phosphorylated at the 5'-hydroxymethyl group. The first total synthesis of vitamin B6 was obtained by the condensation of acetylacetone and cyanacetamide. All living beings need vitamin B6 for their existence. However, only microorganisms and plants are able to synthesize it de novo. The role of vitamin B6 is related to a number of metabolic processes , and also plays a role like a cofactor in certain enzyme-catalyzed reactions. Vitamin B6 is essential for more than 100 enzymes involved in protein metabolism. The most studied coenzymic activity is one of the pytidoxal-5'-phosfate (PLP), PLP-dependent enzymes are involved in important steps of amino acid metabolism, processes of decarboxylation and racemization, hemoglobin formation and chlorophyll biosynthesis. Vitamin B6 could have a role in preventing oxidative stress of the cells. A deficiency of vitamin B6 in the human diet encompasses the full spectrum of clinical disorders, some of them more serious, such as hyperhomocysteinaemia and increases the risk for atherosclerosis.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:182:552557
Study programmeTitle: Chemistry
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) kemije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
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Created on2017-01-04 08:51:56