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master's thesis
Priprava kvaternih soli nikotinamida sa supstituiranim fenacil-bromidima u mikrovalnom reaktoru
Osijek: Josip Juraj Strossmayer University of Osijek, Department of Chemistry, 2018. urn:nbn:hr:182:732817
Đurin, Antonia
Josip Juraj Strossmayer University of Osijek
Department of Chemistry
Department of Analytical, Organic and Applied Chemistry

Institutional repository: Repository of the Department of Chemistry, Osijek

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Đurin, A. (2018). Priprava kvaternih soli nikotinamida sa supstituiranim fenacil-bromidima u mikrovalnom reaktoru (Master's thesis). Osijek: Josip Juraj Strossmayer University of Osijek, Department of Chemistry. Retrieved from https://urn.nsk.hr/urn:nbn:hr:182:732817

Đurin, Antonia. "Priprava kvaternih soli nikotinamida sa supstituiranim fenacil-bromidima u mikrovalnom reaktoru." Master's thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, 2018. https://urn.nsk.hr/urn:nbn:hr:182:732817

Đurin, Antonia. "Priprava kvaternih soli nikotinamida sa supstituiranim fenacil-bromidima u mikrovalnom reaktoru." Master's thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, 2018. https://urn.nsk.hr/urn:nbn:hr:182:732817

Đurin, A. (2018). 'Priprava kvaternih soli nikotinamida sa supstituiranim fenacil-bromidima u mikrovalnom reaktoru', Master's thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, accessed 22 December 2024, https://urn.nsk.hr/urn:nbn:hr:182:732817

Đurin A. Priprava kvaternih soli nikotinamida sa supstituiranim fenacil-bromidima u mikrovalnom reaktoru [Master's thesis]. Osijek: Josip Juraj Strossmayer University of Osijek, Department of Chemistry; 2018 [cited 2024 December 22] Available at: https://urn.nsk.hr/urn:nbn:hr:182:732817

A. Đurin, "Priprava kvaternih soli nikotinamida sa supstituiranim fenacil-bromidima u mikrovalnom reaktoru", Master's thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, Osijek, 2018. Available at: https://urn.nsk.hr/urn:nbn:hr:182:732817

Metadata
TitlePriprava kvaternih soli nikotinamida sa supstituiranim fenacil-bromidima u mikrovalnom reaktoru
Title (english)Preparation of quaternary salts of nicotinamide with supstituted phenacyl bromides in a microwave reactor
AuthorAntonia Đurin
MentorMartina Šrajer Gajdošik (mentor)
MentorDajana Gašo-Sokač (mentor)
Committee memberElvira Kovač-Andrić (predsjednik povjerenstva)
Committee memberMartina Šrajer Gajdošik (član povjerenstva)
Committee memberDajana Gašo-Sokač (član povjerenstva)
GranterJosip Juraj Strossmayer University of Osijek
Department of Chemistry
(Department of Analytical, Organic and Applied Chemistry)
Osijek
Defense date and country2018-09-28, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Organic Chemistry
Abstract
Kvaterne soli heterocikličkih amina kao što je nikotinamid imaju širok spektar terapijskih učinaka, a koriste se kao antibakterijska i antikancerogena sredstva. U ovom su radu izvedene reakcije kvaternizacije potpomognute mikrovalnim zagrijavanjem nikotinamida sa supstituiranim fenacil-bromidima u acetonu. Prinos sinteze pomoću mikrovalnog zagrijavanja u acetonu je uspoređen s konvencionalnim zagrijavanjem. Budući da reakcija stvaranja soli nikotinamida pripada reakciji nukleofilne supstitucije (\( S_{n}2 \)), prinos produkta je pod utjecajem strukture reagensa, nikotinamida i elektrofila. Istražen je utjecaj strukture elektrofila na prinos reakcije kvaternizacije. Elektrofili su supstituirani fenacil-bromidi s različitim elektron akceptorskim i elektron donorskim skupinama u para- i ortho položaju.
Abstract (english)
Quaternary salts of heterocyclic amines like nicotinamide have a wide range of terapeutic effects, they have been used as antibacterial and anticarcinogenic agents. In this thesis reaction of quaternization under microwave heating of nicotinamide with substituted phenacyl bromides in acetone was performed. The synthesis yield by microwave heating in acetone is compered to conventional heating. Since the reaction of formation of nicotinamide salts belongs to the reaction of nucleophilic substitution (\( S_{n}2 \)) the yield of the product is affected by the structure of boath reagents, nicotinamide and electrophiles. The influence of structure of electrophile on the quaternization reaction yield was investigated. Electrophiles are phenacyl bromides with different electron withdrawing and electron donating substituents in para- and ortho- position.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:182:732817
Study programmeTitle: Graduate University Study of Chemistry; research direction
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra kemije (magistar/magistra kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2018-12-27 12:39:34