prikaz prve stranice dokumenta Sinteza i karakterizacija fluorescentnog osjetila za H2S
  Download
PDF 1.99 MB
master's thesis
Sinteza i karakterizacija fluorescentnog osjetila za H2S
Osijek: Josip Juraj Strossmayer University of Osijek, Department of Chemistry, 2018. urn:nbn:hr:182:650258
Varaždinac, Marinela
Josip Juraj Strossmayer University of Osijek
Department of Chemistry
Department of Analytical, Organic and Applied Chemistry

Institutional repository: Repository of the Department of Chemistry, Osijek

Cite this document

Varaždinac, M. (2018). Sinteza i karakterizacija fluorescentnog osjetila za H2S (Master's thesis). Osijek: Josip Juraj Strossmayer University of Osijek, Department of Chemistry. Retrieved from https://urn.nsk.hr/urn:nbn:hr:182:650258

Varaždinac, Marinela. "Sinteza i karakterizacija fluorescentnog osjetila za H2S." Master's thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, 2018. https://urn.nsk.hr/urn:nbn:hr:182:650258

Varaždinac, Marinela. "Sinteza i karakterizacija fluorescentnog osjetila za H2S." Master's thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, 2018. https://urn.nsk.hr/urn:nbn:hr:182:650258

Varaždinac, M. (2018). 'Sinteza i karakterizacija fluorescentnog osjetila za H2S', Master's thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, accessed 27 November 2024, https://urn.nsk.hr/urn:nbn:hr:182:650258

Varaždinac M. Sinteza i karakterizacija fluorescentnog osjetila za H2S [Master's thesis]. Osijek: Josip Juraj Strossmayer University of Osijek, Department of Chemistry; 2018 [cited 2024 November 27] Available at: https://urn.nsk.hr/urn:nbn:hr:182:650258

M. Varaždinac, "Sinteza i karakterizacija fluorescentnog osjetila za H2S", Master's thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, Osijek, 2018. Available at: https://urn.nsk.hr/urn:nbn:hr:182:650258

Metadata
TitleSinteza i karakterizacija fluorescentnog osjetila za H2S
Title (english)Synthesis and evaluation of fluorescent probe for H2S sensing
AuthorMarinela Varaždinac
MentorAleksandar Sečenji (mentor)
Committee memberMirela Samardžić (predsjednik povjerenstva)
Committee memberAleksandar Sečenji (član povjerenstva)
Committee memberOlivera Galović (član povjerenstva)
GranterJosip Juraj Strossmayer University of Osijek
Department of Chemistry
(Department of Analytical, Organic and Applied Chemistry)
Osijek
Defense date and country2018-03-12, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Organic Chemistry
Abstract
Sumporovodik (\( H_{2}S \)) je prvenstveno poznat kao toksin i njegova biološka uloga često nije prepoznata, međutim \( H_{2}S \) se javlja u organizmima, od bakterija do sisavaca, kao redoks aktivna signalna molekula, odnosno biološki glasnik. Njegova koncentracija u organizmima iznosi 10-100 μmol/\( dm^{3} \) i povezana je s različitim patološkim procesima. Zbog tako male koncentracije potrebne su novije i osjetljivije metode detekcije. Problem s određivanjem \( H_{2}S \) u živim organizmima je brz katabolizam zbog kojeg dolazi do stalne promjene njegove koncentracije i posljedica toga su netočni rezultati. Kao jedno od rješenja tih problema, predlažu se metode bazirane na fluorescenciji. Cilj ovog rada bio je sintetizirati reverzibilno fluorescentno osjetilo za \( H_{2}S \) te okarakterizirati dobiveni spoj. Pripravljena su tri konačna produkta: \( Se-P_{1}\), \( Se-P_{2}\) i \( P_{1}-NaN_{3}\), a njihova karakterizacija provedena je FT-IR spektroskopijom i fluorescentnom spektroskopijom. Navedenim metodama utvrđeno je kako je sintezom \( Se-P_{1}\) dobiveno reverzibilno fluorescentno osjetilo za \( H_{2}S \), sinteza \( Se-P_{2}\) se pokazala neuspješnom, a sintezom \( P_{1}-NaN_{3}\) dobiveno je reverzibilno pH osjetilo, ali ne i osjetilo za \( H_{2}S \).
Abstract (english)
Hydrogen sulfide (\( H_{2}S \)) is commonly known as a toxin and its biological role is often neglected. \( H_{2}S \) is a redox active signal molecule and can be found in different organisms, from bacteria to mammals, where it has a role of a biological messenger. Its concentration in live organisms is 10-100 μmol/\( dm^{3} \) and can be connected with different pathological processes. Hence, the new and more sensitive detection methods are necessary. The main problem when it comes to \( H_{2}S \) detection is its fast catabolism, which means that the concentration is constantly changing, giving us the incorrect results. As one of the possible solutions, fluorescence based methods are suggested. The aim of this paper was to synthesize a reversible fluorescent probe for \( H_{2}S \) sensing and characterize the compound. Three final products were made:\( Se-P_{1}\) , \( Se-P_{2}\) i \( P_{1}-NaN_{3}\), and were characterized using FT-IR spectroscopy and fluorescence spectroscopy. These methods showed that a reversible fluorescent probe for \( H_{2}S \) sensing was indeed synthesized (\( Se-P_{1}\)). \( Se-P_{2}\) synthesis wasn't successful and it was shown that the \( P_{1}-NaN_{3}\) works as a reversible pH probe, but not an \( H_{2}S \) probe.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:182:650258
Study programmeTitle: Graduate University Study of Chemistry; research direction
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra kemije (magistar/magistra kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2018-12-31 10:00:44