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master's thesis
Racionalni dizajn sustava za nazalnu dostavu lijeka u središnji živčani sustav
Osijek: Josip Juraj Strossmayer University of Osijek, Department of Chemistry, 2021. urn:nbn:hr:182:749477
Herendić, Martina
Josip Juraj Strossmayer University of Osijek
Department of Chemistry
Department of Analytical, Organic and Applied Chemistry

Institutional repository: Repository of the Department of Chemistry, Osijek

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Herendić, M. (2021). Racionalni dizajn sustava za nazalnu dostavu lijeka u središnji živčani sustav (Master's thesis). Osijek: Josip Juraj Strossmayer University of Osijek, Department of Chemistry. Retrieved from https://urn.nsk.hr/urn:nbn:hr:182:749477

Herendić, Martina. "Racionalni dizajn sustava za nazalnu dostavu lijeka u središnji živčani sustav." Master's thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, 2021. https://urn.nsk.hr/urn:nbn:hr:182:749477

Herendić, Martina. "Racionalni dizajn sustava za nazalnu dostavu lijeka u središnji živčani sustav." Master's thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, 2021. https://urn.nsk.hr/urn:nbn:hr:182:749477

Herendić, M. (2021). 'Racionalni dizajn sustava za nazalnu dostavu lijeka u središnji živčani sustav', Master's thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, accessed 14 July 2024, https://urn.nsk.hr/urn:nbn:hr:182:749477

Herendić M. Racionalni dizajn sustava za nazalnu dostavu lijeka u središnji živčani sustav [Master's thesis]. Osijek: Josip Juraj Strossmayer University of Osijek, Department of Chemistry; 2021 [cited 2024 July 14] Available at: https://urn.nsk.hr/urn:nbn:hr:182:749477

M. Herendić, "Racionalni dizajn sustava za nazalnu dostavu lijeka u središnji živčani sustav", Master's thesis, Josip Juraj Strossmayer University of Osijek, Department of Chemistry, Osijek, 2021. Available at: https://urn.nsk.hr/urn:nbn:hr:182:749477

Metadata
TitleRacionalni dizajn sustava za nazalnu dostavu lijeka u središnji živčani sustav
Title (english)Rational system design for nasal drug delivery to the central nervous system
AuthorMartina Herendić
MentorAleksandar Sečenji (mentor)
Committee memberTomislav Balić (predsjednik povjerenstva)
Committee memberAleksandar Sečenji (član povjerenstva)
Committee memberMirela Samardžić (član povjerenstva)
GranterJosip Juraj Strossmayer University of Osijek
Department of Chemistry
(Department of Analytical, Organic and Applied Chemistry)
Osijek
Defense date and country2021-12-13, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Organic Chemistry
Abstract
Veliki izazov u primjeni lijekova s djelovanjem na središnji živčani sustav (SŽS) predstavljaju odabir i priprema sustava koji ima mogućnost dostaviti lijek u dovoljnoj količini i odgovarajućem obliku. Upotreba racionalnog dizajniranja pri osmišljavanju rješenja doprinosi lakšem donošenju zaključaka i manjim troškovima u eksperimentalnim procesima. Iz tog razloga glavni cilj ovog rada je prikazati svojstva različitih sustava kao i svojstva nazalne primjene te prikazati mogućnost racionalnog dizajniranja u svrhu olakšavanja odabira najprikladnijeg dostavnog sustava. U radu je detaljno opisana nosna sluznica te su opisani sustavi i karakteristike koje utječu na efikasnost dostave lijeka. Kao pokusni lijek odabran je lijek hidrofilnog karaktera, dopamin. Predloženi sustav za dostavu dopamina je nanočestica sastavljena od polilakto-ko-glikolne kiseline koja se može stabilizirati pomoću Tween®80. Uklapanjem te čestice u hidrogel postiže se bolja kompatibilnost s nosnom sluznicom i pospješuje se intranazalna dostava.
Abstract (english)
A major challenge in the use of drugs with action on the central nervous system (CNS) is the selection and preparation of a system that can deliver the drug in sufficient quantity and appropriate form. The use of rational design in designing solutions contributes to an easier drawing of conclusions and lower costs in experimental processes. For this reason, the main goal of this master's thesis is to present the properties of different systems and the properties of nasal application and to show the possibility of rational design to facilitate the selection of the most appropriate delivery system. The thesis describes in detail the nasal mucosa and describes the systems and characteristics that affect the efficiency of drug delivery. A hydrophilic drug, dopamine, was chosen as the experimental drug. The proposed dopamine delivery system is a nanoparticle composed of polylacto-co-glycolic acid that can be stabilized by Tween®80. Incorporating these particles into the hydrogel allows for better compatibility with the nasal mucosa, and intranasal delivery should improve.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:182:749477
Study programmeTitle: Graduate University Study of Chemistry; research program; specializations in: Research program
Course: Research program
Study programme type: university
Study level: graduate
Academic / professional title: magistar/magistra kemije (magistar/magistra kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2022-08-04 09:00:49