Introduction: Chronic low back pain is the leading cause of global disability in the world which causes a decline in quality of life and increases the healthcare costs. There are different types of manual therapies used in the treatment of chronic low back pain, but recent research shows that a rehabilitation model, which combines manual therapy and exercise, allows considerably better results than their separate usage. The review of the previous research did not provide any study that analyses the impact of manual therapy using Yumeiho technique and exercising, related to chronic low back pain. Consequently, the aim of this study is to analyze the impact of a rehabilitation program which includes Yumeiho manual therapy and exercise, in order to solve chronic low back pain and compare it to standard physical therapy. Methods: The study included 50 participants, aged 40 to 60 (M=51.60; sd=±5.73), randomly divided into two groups of the same number of participants. The participants in the group 1 (n=25) were conducting manual therapy based on Yumeiho technique combined with exercise, while participants of the group 2 (n=25) were conducting a physical therapy treatment that consisted of electrotherapy and the therapeutic ultrasound, combined with exercises for strengthening abdominal muscles and stretching the lumbar part of the spine. The measurement procedure consisted the initial and final testing of low back pain during movement (VAS pain scale), quality of life (Short Form 36), functionality of movement in everyday life (Oswestry Disability Index), the level of depression (Beck Depression Inventory), spine mobility (BENT IN THE NARROW POSTURE), static balance (STILL STANDING ON ONE LEG) and neuropathic pain (Leeds assesment of neuropathic symptoms and signs). Between the initial and final testing, a three-week therapy program was done (15 treatments in total). Apart from final measurement, conducted as therapy ended, repeated measurement of pain, quality of life and functionality of the movement in everyday life was taken one, two and three months after the rehabilitation program had finished. Results: After the rehabilitation protocol, which included manual therapy based on Yumeiho technique and exercise, significant improvements (p<0,05) between the initial and final testing of all monitored variables (except for balance) were recorded. In participants who were conducted physical therapy, statistically significant improvements (p<0,05) were recorded in: decreasing pain, physical health improvement, spine mobility, decreasing depression and better functionality of movement in everyday life. Significant improvements were not recorded for mental health, neuropathic pain and balance. The main finding of this study indicates that, immediately after the implementation of the rehabilitation protocol, significant improvements (p<0,05) were recorded in all the variables (VAS, ODI, SF-36, BENT, BECK, LANSS) except for the balance, among the group who combined Yumeiho manual therapy and exercises. It should be emphasized that the achieved effects have the same dynamics of decline immediately after the therapies. No therapy contributes to the longer duration of the achieved effects. The results remain equally between groups. Conclusion: In conclusion, the results suggest that the rehabilitation protocol which combines manual therapy and exercises, is more efficient method for the treatment of patients suffering from chronic low back pain, compared to standard physical therapy. Taking into account a global lack of the research on the effects of manual therapy using Yumeiho technique, the results of this study contribute to a better understanding of technique, which, even though used in practice, has not been examined enough. Moreover, this study helps to understand better efficiency of the therapeutic program that includes manual therapy based on Yumeiho technique combined with exercise. Especially in relation to standard physical therapy without Yumeiho, within a treatment of numerous variables which describe the overall health of people who suffer of chronic low back pain. Further studies are necessary to acquire a clearer picture towards a comparison of the used rehabilitation model with other methods and longer monitoring in the post-rehabilitation period.