Down syndrome is a genetic disorder involving various combinations of birth defects, including some degree of mental retardation. It is the most common chromosomal disorder in humans, occurring in about 1 in 700 newborns. Down syndrome is caused by abnormalities in chromosomes that usually develop before fertilization or in very rare cases after fertilization. The most common symptoms of Down syndrome are obesity, dementia, loose joints and an increased risk of cardiovascular diseases, which are also the cause of the shorter life expectancy of people with Down syndrome. Physical activity is recommended for people with Down syndrome primarily because they have an increased risk of cardiovascular diseases and are prone to obesity. The benefits of physical activity for people with Down syndrome are the main driver of increasingly frequent research on the connection between physical activity and the development of functional and motor abilities. Taking into account the mentioned facts, the main goal of this paper was to determine whether there is a statistically significant difference in the initial and final results of tests for the assessment of motor and functional abilities in people with Down syndrome after the implementation of a 12-week basketball training program. The sample of respondents for the implementation of the research consisted of a total of 9 respondents (N=9; 5 M and 4 F, age=26.33±2.24 years, height=155.27±12.31 cm, weight=73.51±15 .44, %fat=23.70±8.71, BMI=30.77±7.69) who were exposed to basketball training for a period of 12 weeks. The t-test for dependent samples determined the results that show that there is a statistically significant difference in the arithmetic means of the results between the initial and final testing in the beep test (BEEP-1 and BEEP-2), the initial and final test of ball handling per minute (VLM-1 and VLM-2), of the initial and final shot test from a distance of three meters (S3M-1 and S3M-2). It was concluded that a 12-week program of basketball training in a circular way with a polygon setup is suitable for the development of aerobic abilities, coordination and precision in people with Down syndrome.