The main goal of this review paper was to determine whether there is an impact of statins on the muscle-tendon system, with an emphasis on potential negative effects, such as tendinopathy. Although statins are known to regulate cholesterol, research suggests they can cause changes in the tendons, which can result in pain and reduced functionality. The systematic review is based on research published in English. The keywords "Statin" AND "Tendinopathy" were used during the search for all papers from 1980 to 2023. For the purposes of this review paper, two electronic databases were used: PubMed and Google Scholar. The analyzed studies showed diversity in the population but did not clearly identify the key factors for the occurrence of tendinopathy. Although different types of statins have been investigated, no consistent association with tendinopathies has been demonstrated. In most studies, negative changes in the tendons, especially the Achilles tendon, were observed, but only two studies showed statistically significant results. While some studies have highlighted the negative effects, others have also highlighted the positive effects of statins on the musculoskeletal system. It is important to note that research on animals is also relevant for a better understanding of this issue. A systematic review of the literature highlights the need for an individualized approach in prescribing statins and monitoring the health of the musculoskeletal system of patients. The results of the research are expected to contribute to a better understanding of the risks and use of statin administration in clinical practice, with the potential improvement of health care and quality of life of patients.