The lack of clear knowledge regarding the specific effects of various types of physical activity and diet on myosteatosis creates challenges in developing tailored preventive and therapeutic programs for this condition. Although many studies have investigated the general benefits of physical activity on muscle health, precise data on how different types of physical activities and dietary interventions can synergistically influence the development or progression of myosteatosis are missing. Therefore, it is crucial to explore the specific impacts of aerobic and anaerobic activities, as well as strength and endurance training, various dietary approaches, and their combinations on the presence, progression, or reversibility of myosteatosis. Myosteatosis is characterized by the accumulation of fat tissue within skeletal muscles, reducing their functionality and metabolic health. This can lead to decreased muscle strength, endurance, and insulin sensitivity, increasing the risk od metabolic disorders. Prevention and treatment of myosteatosis involve regular physical activity, especially aerobic exercises and strength training, along with a balanced diet rich in proteins and healthy fats. The combination of these interventions is essential for maintaining muscle health and preventing fat accumulation in muscles. The aim of this thesis is to analyze available scientific studies and investigate and synthesize knowledge on the impact of different types of physical activities and dietary strategies on myosteatosis. Special attention will be paid to understanding the specific mechanisms of action of aerobic and anaerobic activities, strength training, and endurance training, as well as their combinations, on fat metabolism in muscles and the overall development of myosteatosis. Through the analysis of available literature, the goal is to find the most effective physical activity and dietary strategies for the prevention, management, and, where possible, reversibility of myosteatosis, thereby providing relevant guidelines for the development of personalized therapeutic programs for individuals with this condition.