This paper will present specific methods that need to be applied in working with children with autism. Apart from that, it will provide the basic recommendations and guidelines for the implementation of physical exercise with this population of children. Autism is a complex and all-inclusive developmental disorder and, as such, represents a major challenge for all experts and people who choose to deal with the problem. First of all, every kinesiology expert who works with autistic children should be introduced to and educated about specific methods and guidelines that allow the implementation of physical exercise with this population of children. It is very important to note that children with autism are more likely to become obese and develop many diseases. For this reason, a kinesiology expert has to be able to choose and individually adapt physical exercise to their needs. Due to the lower level of motor and functional abilities, children with autism tend to avoid and quickly give up on physical exercise that they often perceive as a big challenge and stress. It is therefore very important to follow the guidelines that enable successful work with autistic children. Adapted physical activity is an important factor for the health and life of each individual, as well as children with autism. Properly dosed and well implemented physical activity affects the harmonious psychological and physiological development of autistic children. In addition, it has a positive effect on child` s adaptation to different life situations, such as the acquisition of friends and spending quality free time. A multi-disciplinary team of experts should be included in working with autistic children. This team should consist of kinesiotherapists, educational rehabilitators, physiotherapists and doctors who would give their professional opinion and contribute to the improvement of the child` s health condition. In combination with medical therapy, educational and rehabilitation support, adapted physical therapy should certainly be an important part of every child with autism.