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undergraduate thesis
Miješani metoksidni i fenantridinski derivat kaliks[4]arena kao teranostički receptor
završni rad
Split: University of Split, Faculty of Chemistry and Technology, 2022. urn:nbn:hr:167:122763
Marušić, Iva
University of Split
Faculty of Chemistry and Technology
Division of Chemistry

Institutional repository: Repository of the Faculty of chemistry and technology

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Marušić, I. (2022). Miješani metoksidni i fenantridinski derivat kaliks[4]arena kao teranostički receptor : završni rad (Undergraduate thesis). Split: University of Split, Faculty of Chemistry and Technology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:167:122763

Marušić, Iva. "Miješani metoksidni i fenantridinski derivat kaliks[4]arena kao teranostički receptor : završni rad." Undergraduate thesis, University of Split, Faculty of Chemistry and Technology, 2022. https://urn.nsk.hr/urn:nbn:hr:167:122763

Marušić, Iva. "Miješani metoksidni i fenantridinski derivat kaliks[4]arena kao teranostički receptor : završni rad." Undergraduate thesis, University of Split, Faculty of Chemistry and Technology, 2022. https://urn.nsk.hr/urn:nbn:hr:167:122763

Marušić, I. (2022). 'Miješani metoksidni i fenantridinski derivat kaliks[4]arena kao teranostički receptor : završni rad', Undergraduate thesis, University of Split, Faculty of Chemistry and Technology, accessed 18 December 2024, https://urn.nsk.hr/urn:nbn:hr:167:122763

Marušić I. Miješani metoksidni i fenantridinski derivat kaliks[4]arena kao teranostički receptor : završni rad [Undergraduate thesis]. Split: University of Split, Faculty of Chemistry and Technology; 2022 [cited 2024 December 18] Available at: https://urn.nsk.hr/urn:nbn:hr:167:122763

I. Marušić, "Miješani metoksidni i fenantridinski derivat kaliks[4]arena kao teranostički receptor : završni rad", Undergraduate thesis, University of Split, Faculty of Chemistry and Technology, Split, 2022. Available at: https://urn.nsk.hr/urn:nbn:hr:167:122763

Metadata
TitleMiješani metoksidni i fenantridinski derivat kaliks[4]arena kao teranostički receptor : završni rad
Title (english)Calixarene derivatives in theranostics : bachelor thesis
AuthorIva Marušić
MentorMarina Tranfić Bakić (mentor)
Committee memberMladen Miloš (predsjednik povjerenstva)
Committee memberIvana Škugor Rončević (član povjerenstva)
Committee memberMarina Tranfić Bakić (član povjerenstva)
GranterUniversity of Split
Faculty of Chemistry and Technology
(Division of Chemistry)
Split
Defense date and country2022-09-27, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Abstract
S ciljem procjene potencijala primjene derivata kaliksarena 5,11,17,23-tetra-tert-butil-25,27- dimetoksi-26,28-bis-((fenantridin-6-il)metoksi)kaliks[4]aren (D) u teranostici, u ovom su radu istražena njegova kompleksacijska svojstva s bojama rodaminom B, auraminom O i fluoresceinom te lijekom timokinonom pri čemu je zbog slabe topljivosti liganda korišten sustav otapala acetonitril/diklormetan. Konstante stabilnosti određene su na temelju provedenih spektrofotometrijskih titracija. Za kompleks [D- rodaminB] lg(K/dm 3 mol -1 ) = 4,55 + 0,01 te lg(K/dm 3 mol -1 ) = 5,61 + 0,05 za kompleks [D-auraminO]. Za kompleks [D-fluorescein] nije bilo moguće odrediti vrijednost konstante stabilnosti iako su eksperimentalni podaci upućivali na to da do stvaranja kompleksa dolazi. Upravo suprotno, s timokinonom kompleksiranje nije opaženo, vjerojatno zbog njegove strukturne nekomplementarnosti s veznim mjestom liganda. Proučavani derivat kaliksarena D dobar je receptor za istraživane boje, pri čemu je najveći afinitet pokazao prema auraminu O. Iako je ustanovljeno da ovaj derivat kaliksarena ima jako dobra receptorska svojstva, on nije topljiv u vodi, što je nužno za primjenu u teranostici, ali se očekuje da bi njegov vodotopivi analog koji bi iskoristio potencijal fenantridinskih skupina u veznom mjestu, mogao pokazati velik potencijal u teranostičkoj primjeni.
Abstract (english)
With the aim of evaluating the application potential of calixarene derivatives 5,11,17,23-tetra-tert- butyl-25,27-dimethoxy-26,28-bis-((phenanthridin-6-yl)methoxy)calix[4]arene (D), in this thesis, its complexation properties with the dyes rhodamine B, auramine O and fluorescein and the drug thymoquinone were investigated. The stability constants were determined based on spectrophotometric titrations and the obtained values were lg(K/dm 3 mol -1 ) = 4.55 + 0.01 for [D-rhodamineB], and for complex [D-auramineO] lg(K/dm 3 mol -1 ) = 5.61 + 0.05. The value of the stability constant for [D-fluorescein] could not be determined, only estimated based on experimental data, while the formation of the complex with thymoquinone was not observed. The results indicate good binding of the studied dyes by the studied calixarene derivative. At the same time, the highest affinity of ligand D towards the formation of a complex was shown for auramine O. Although it was shown that this calixarene derivative has very good receptor properties, it is not soluble in water, which is necessary for its application in theranostics, but it is espected that its water-soluble analogue, that would exploit the potential of phenantridine groups at the binding site, could have great potential in theranostic applications.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:167:122763
Study programmeTitle: Food technology - undergraduate - university
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/ baccalaurea) inženjer/ inženjerka prehrambene tehnologije (sveučilišni/a prvostupnik/ prvostupnica (baccalaureus/ baccalaurea) inženjer/ inženjerka prehrambene tehnologije)
Type of resourceText
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Created on2023-04-04 06:45:53