prikaz prve stranice dokumenta Pronalaženje dokaza o djelotvornosti i sigurnosti primjene selenija u liječenju Hashimotova tiroiditisa: sustavni pregled literature
  Download
PDF 1.21 MB
master's thesis
Pronalaženje dokaza o djelotvornosti i sigurnosti primjene selenija u liječenju Hashimotova tiroiditisa: sustavni pregled literature
diplomski rad
Split: University of Split, Faculty of Chemistry and Technology, 2017. urn:nbn:hr:167:024037
Kuveždić, Danijela
University of Split
Faculty of Chemistry and Technology
University of Split
School of Medicine

Institutional repository: Repository of the Faculty of chemistry and technology

Cite this document

Kuveždić, D. (2017). Pronalaženje dokaza o djelotvornosti i sigurnosti primjene selenija u liječenju Hashimotova tiroiditisa: sustavni pregled literature : diplomski rad (Master's thesis). Split: University of Split, Faculty of Chemistry and Technology; Split: University of Split, School of Medicine. Retrieved from https://urn.nsk.hr/urn:nbn:hr:167:024037

Kuveždić, Danijela. "Pronalaženje dokaza o djelotvornosti i sigurnosti primjene selenija u liječenju Hashimotova tiroiditisa: sustavni pregled literature : diplomski rad." Master's thesis, University of Split, Faculty of Chemistry and Technology; University of Split, School of Medicine, 2017. https://urn.nsk.hr/urn:nbn:hr:167:024037

Kuveždić, Danijela. "Pronalaženje dokaza o djelotvornosti i sigurnosti primjene selenija u liječenju Hashimotova tiroiditisa: sustavni pregled literature : diplomski rad." Master's thesis, University of Split, Faculty of Chemistry and Technology; University of Split, School of Medicine, 2017. https://urn.nsk.hr/urn:nbn:hr:167:024037

Kuveždić, D. (2017). 'Pronalaženje dokaza o djelotvornosti i sigurnosti primjene selenija u liječenju Hashimotova tiroiditisa: sustavni pregled literature : diplomski rad', Master's thesis, University of Split, Faculty of Chemistry and Technology; University of Split, School of Medicine, accessed 26 December 2024, https://urn.nsk.hr/urn:nbn:hr:167:024037

Kuveždić D. Pronalaženje dokaza o djelotvornosti i sigurnosti primjene selenija u liječenju Hashimotova tiroiditisa: sustavni pregled literature : diplomski rad [Master's thesis]. Split: University of Split, Faculty of Chemistry and Technology; Split: University of Split, School of Medicine; 2017 [cited 2024 December 26] Available at: https://urn.nsk.hr/urn:nbn:hr:167:024037

D. Kuveždić, "Pronalaženje dokaza o djelotvornosti i sigurnosti primjene selenija u liječenju Hashimotova tiroiditisa: sustavni pregled literature : diplomski rad", Master's thesis, University of Split, Faculty of Chemistry and Technology, Split; University of Split, School of Medicine, Split, 2017. Available at: https://urn.nsk.hr/urn:nbn:hr:167:024037

Metadata
TitlePronalaženje dokaza o djelotvornosti i sigurnosti primjene selenija u liječenju Hashimotova tiroiditisa: sustavni pregled literature : diplomski rad
Title (english)Finding evidence of efficacy and safety of selenium supplementation in trearment of Hashimoto´s thyroiditis: systematic review approach : diploma thesis
AuthorDanijela Kuveždić
MentorDarko Modun (mentor)
Committee memberRenata Pecotić (predsjednik povjerenstva)
Committee memberZoran Valić (član povjerenstva)
Committee memberDarko Modun (član povjerenstva)
GranterUniversity of Split
Faculty of Chemistry and Technology
Split
GranterUniversity of Split
School of Medicine
Split
Defense date and country2017-10-05, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Abstract
Cilj istraživanja: Pronaći najbolje dostupne dokaze o sigurnosti i djelotvornosti primjene selenija u liječenju Hashimotova tiroiditisa. Materijali i metode: Na stranici Cochrane knjižnice je pronađen sustavni pregled „Selenium supplementation for Hashimoto's thyroiditis (Review)“ koji je temelj ovog istraživanja. Zatim se pretraživanje nastavilo u bazama MEDLINE (PubMed), CENTRAL i DARE za pronalazak novih randomiziranih kontroliranih pokusa i sustavnih pregleda. Na temelju kriterija uključenja navedenih u sustavnom pregledu odlučeno je o njihovom uključenju u ovo istraživanje. Nakon pretrage napravljena je procjena kvalitete Cochrane sustavnog pregleda koristeći R- AMSTAR ljestvicu. Rezultati: Četiri studije uključene u Cochrane sustavni pregled, sa nejasnim do visokim rizikom od pristranosti, su uključile ukupno 463 sudionika u istraživanje. Jedna studija sa visokim rizikom od pristranosti je pokazala statistički značajno poboljšanje subjektivnog općeg stanja sudionika koji su uzimali selenij u kombinaciji s LT4 u usporedbi sa kontrolnom skupinom. Tri studije su pokazale kako je uzimanje selenija povezano s redukcijom razine anti-TPOAb, ali sve dok su te vrijednosti pozitivne ne smatraju se klinički značajne. Samo dvije studije su prijavljivale nuspojave te su rezultati tih studija pokazali kako suplementacija selenijem nije dovela do statistički značajnog povećanja broja nuspojava u odnosu na placebo. Pronađeno je ukupno 5 novih randomiziranih kontroliranih pokusa koji su uključeni u istraživanje. Samo dvije studije su istraživale učinak selenija na kvalitetu života te su obje pokazale kako značajnog učinka nema. U dvije studije je kod sudionika koji su uzimali selenij pokazano smanjenje razine anti-TPOAb, a ostale tri studije su pokazale kako nema statistički značajne redukcije. Jedna studija je prijavila nuspojavu gubitka kose, ali ona se pojavila jednako i u istraživačkoj i u kontrolnoj skupini. Ostale studije ili nisu prijavljivale nuspojave ili su prijavile kako nuspojava nije bilo. Zaključak: Na temelju pronađenih randomiziranih kliničkih pokusa i sustavnih pregleda ne može se izvesti zaključak o djelotvornosti primjene selenija u liječenju Hashimotova tiroiditisa. Potrebno je provesti dodatne randomizirane kontrolirane pokuse koji bi mogli pružiti pouzdane dokaze koji bi mogli pomoći u donošenju kliničkih odluka.
Abstract (english)
Objectives: Finding the best available evidence of efficacy and safety of selenium supplementation in treatment of Hashimoto's thyroiditis. Material and methods: The basis of this research is systematic review "Selenium supplementation for Hashimoto's thyroiditis (Review)" which was found on the Cochrane Library website. Furthermore, a search was performed in MEDLINE (PubMed), CENTRAL and DARE databases to find new randomized controlled trials and systematic reviews. Based on the inclusion criteria listed in the systematic review, it was decided whether they would be included in this research. After the search was performed, the Cochrane systematic review was evaluated using the R-AMSTAR tool. Results: Four studies included in the Cochrane systematic review, with unclear to high risk of bias, involved 463 participants. One study with high risk of bias showed statistically significant improvement in the subjective well- being of participants who took selenium in combination with LT4 compared to the control group. Three studies have shown that the use of selenium is associated with the reduction of anti-TPOAb levels, but as long as these values are positive they are not considered clinically significant. Only two studies reported adverse events and the results of these studies showed that selenium supplementation did not have a statistically significant impact on the increase of the number of adverse events compared to placebo. A total of 5 new randomized controlled trials were included in this investigation. Only two studies have assessed the effect of selenium on quality of life and both have shown no significant effect. In two studies, use of selenium showed decreased levels of anti-TPOAb, while the other three studies showed no statistically significant reduction in those levels. One study reported adverse event of hair loss, but it appeared equally in both groups, research and control. Other studies either didn’t report adverse events or reported no adverse events. Conclusion: Based on the findings of randomized clinical trials and systematic reviews no conclusions can be drawn about the efficacy of selenium in treating Hashimoto's thyroiditis. Additional randomized controlled trials need to be conducted to provide reliable evidence in order to help in making clinical decisions.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:167:024037
Study programmeTitle: Pharmacy
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Public noteKljučne riječi doradio knjižničar/ Key words are revised by the librarian
Created on2018-06-28 10:29:01