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undergraduate thesis
Antiproliferacijski utjecaj valencena na dvije stanične linije karcinoma
završni rad
Split: University of Split, Faculty of Chemistry and Technology, 2019. urn:nbn:hr:167:793793
Perović, Dorotea
University of Split
Faculty of Chemistry and Technology
Division of Chemistry

Institutional repository: Repository of the Faculty of chemistry and technology

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Perović, D. (2019). Antiproliferacijski utjecaj valencena na dvije stanične linije karcinoma : završni rad (Undergraduate thesis). Split: University of Split, Faculty of Chemistry and Technology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:167:793793

Perović, Dorotea. "Antiproliferacijski utjecaj valencena na dvije stanične linije karcinoma : završni rad." Undergraduate thesis, University of Split, Faculty of Chemistry and Technology, 2019. https://urn.nsk.hr/urn:nbn:hr:167:793793

Perović, Dorotea. "Antiproliferacijski utjecaj valencena na dvije stanične linije karcinoma : završni rad." Undergraduate thesis, University of Split, Faculty of Chemistry and Technology, 2019. https://urn.nsk.hr/urn:nbn:hr:167:793793

Perović, D. (2019). 'Antiproliferacijski utjecaj valencena na dvije stanične linije karcinoma : završni rad', Undergraduate thesis, University of Split, Faculty of Chemistry and Technology, accessed 17 November 2024, https://urn.nsk.hr/urn:nbn:hr:167:793793

Perović D. Antiproliferacijski utjecaj valencena na dvije stanične linije karcinoma : završni rad [Undergraduate thesis]. Split: University of Split, Faculty of Chemistry and Technology; 2019 [cited 2024 November 17] Available at: https://urn.nsk.hr/urn:nbn:hr:167:793793

D. Perović, "Antiproliferacijski utjecaj valencena na dvije stanične linije karcinoma : završni rad", Undergraduate thesis, University of Split, Faculty of Chemistry and Technology, Split, 2019. Available at: https://urn.nsk.hr/urn:nbn:hr:167:793793

Metadata
TitleAntiproliferacijski utjecaj valencena na dvije stanične linije karcinoma : završni rad
Title (english)Antiproliferative effect of valencene on two carcinoma cell lines : bachelor thesis
AuthorDorotea Perović
MentorMila Radan (mentor)
MBZ: 247111
Committee memberOlivera Politeo (predsjednik povjerenstva)
Committee memberDanijela Skroza (član povjerenstva)
Committee memberMila Radan (član povjerenstva)
GranterUniversity of Split
Faculty of Chemistry and Technology
(Division of Chemistry)
Split
Defense date and country2019-09-27, Croatia
Scientific / art field,
discipline and subdiscipline		NATURAL SCIENCES
Chemistry
Abstract
Tumor je naziv za abnormalnu nakupinu tkiva koja moţe biti maligna ili benigna. Maligni oblik tumora epitelnog podrijetla naziva se karcinom. Rak pluća i mokraćnog mjehura jedni su od najčešćih oblika tumora u svijetu i Hrvatskoj. Češće se javljaju kod muškaraca, ali i ţene oboljevaju od njih. Javljaju se u osoba starijih od 60 godina i ukoliko se dijagnosticiraju u ranoj fazi, postoji šansa za izlječenje. Terpenoidi su hlapljivi nezasićeni ugljikovodici ugodna mirisa. Karakteristični su sastojci većine prirodnih i umjetnih mirisnih tvari. Osobito su zanimljivi seskviterpenoidi, terpenoidi izvedeni iz tri izoprenske jedinice koji sadrţe 15 ugljikovih atoma. U ovom radu koristili smo seskviterpenoid valencen, karakterističan za aromucitrusa. Odabrani seskviterpenoid koristio se radi ispitivanja njegovog antiproliferacijskog učinka na staničnu liniju T24 karcinoma mokraćnog mjehura i staničnu liniju A549 karcinoma pluća. Antiproliferacijsko djelovanje ispitano je MTT-testom. Dobiveni rezultati pokazuju jače antiproloferacijsko djelovanje valencena na staničnu liniju T24 i to osobito pri koncentraciji 0,5 mM. Pri niţim koncentracijama u obje stanične linije antiproliferacijsko djelovanje je značajno smanjeno.
Abstract (english)
Tumor is a word for abnormal set of cells which can be malignant or benign. Malignant tumors that are developed form epithelilal are called carcinoma. Lung and urinary bladder cancer are one of the most common types of cancer in the world and so in Croatia. They are more common in men, but women also suffer from them. They usually occur with people older than 60 years old and if it is diagnosed in early phase, there is a chance of successful treatment and recovery. Terpenoids are volatile unsaturated hydrocarbons with pleasant smell. They’re components of majority of natural and artificial odoriferous substances. Of particular interest are sesquiterpenoids which are defined as terpenoids derivated from three isoprene units which include 15 carbon atoms. In this paper we have used sesquiterpenoid valencene which is characteristic of citrus aroma. Selected sesquiterpenoid has been used for analysis of its antiproliferative effect on cell line T24 of urinary bladder cancer and cell line A549 of lung cancer. Antiproliferative effect has been tested by MTT test. Results show strong antiproliferative effect of valencene on cell line T24, especially at concentration level of 0,5 mM. At lower concentrations antiproliferative effect is significantly reduced in both cell lines.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:167:793793
Study programmeTitle: Chemistry
Study programme type: university
Study level: undergraduate
Academic / professional title: sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) kemije (sveučilišni/a prvostupnik/prvostupnica (baccalaureus/baccalaurea) kemije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
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Created on2020-01-31 10:16:51