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master's thesis
Pronalaženje dokaza o djelotvornosti probiotika u prevenciji alergijskih bolesti i preosjetljivosti na hranu u djece: "sustavni" pregled literature
diplomski rad
Split: University of Split, Faculty of Chemistry and Technology, 2016. urn:nbn:hr:167:026167
Omrčen, Monika
University of Split
Faculty of Chemistry and Technology
Division of Chemistry

Institutional repository: Repository of the Faculty of chemistry and technology

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Omrčen, M. (2016). Pronalaženje dokaza o djelotvornosti probiotika u prevenciji alergijskih bolesti i preosjetljivosti na hranu u djece: "sustavni" pregled literature : diplomski rad (Master's thesis). Split: University of Split, Faculty of Chemistry and Technology. Retrieved from https://urn.nsk.hr/urn:nbn:hr:167:026167

Omrčen, Monika. "Pronalaženje dokaza o djelotvornosti probiotika u prevenciji alergijskih bolesti i preosjetljivosti na hranu u djece: "sustavni" pregled literature : diplomski rad." Master's thesis, University of Split, Faculty of Chemistry and Technology, 2016. https://urn.nsk.hr/urn:nbn:hr:167:026167

Omrčen, Monika. "Pronalaženje dokaza o djelotvornosti probiotika u prevenciji alergijskih bolesti i preosjetljivosti na hranu u djece: "sustavni" pregled literature : diplomski rad." Master's thesis, University of Split, Faculty of Chemistry and Technology, 2016. https://urn.nsk.hr/urn:nbn:hr:167:026167

Omrčen, M. (2016). 'Pronalaženje dokaza o djelotvornosti probiotika u prevenciji alergijskih bolesti i preosjetljivosti na hranu u djece: "sustavni" pregled literature : diplomski rad', Master's thesis, University of Split, Faculty of Chemistry and Technology, accessed 26 December 2024, https://urn.nsk.hr/urn:nbn:hr:167:026167

Omrčen M. Pronalaženje dokaza o djelotvornosti probiotika u prevenciji alergijskih bolesti i preosjetljivosti na hranu u djece: "sustavni" pregled literature : diplomski rad [Master's thesis]. Split: University of Split, Faculty of Chemistry and Technology; 2016 [cited 2024 December 26] Available at: https://urn.nsk.hr/urn:nbn:hr:167:026167

M. Omrčen, "Pronalaženje dokaza o djelotvornosti probiotika u prevenciji alergijskih bolesti i preosjetljivosti na hranu u djece: "sustavni" pregled literature : diplomski rad", Master's thesis, University of Split, Faculty of Chemistry and Technology, Split, 2016. Available at: https://urn.nsk.hr/urn:nbn:hr:167:026167

Metadata
TitlePronalaženje dokaza o djelotvornosti probiotika u prevenciji alergijskih bolesti i preosjetljivosti na hranu u djece: "sustavni" pregled literature : diplomski rad
Title (english)Finding the evidence about efficacy of probiotics for the prevention of allergy and food hync-sensivity in children: systematic review : master's thesis
AuthorMonika Omrčen
MentorDarko Modun (mentor)
Committee memberAnte Tonkić (predsjednik povjerenstva)
Committee memberDarko Modun (član povjerenstva)
GranterUniversity of Split
Faculty of Chemistry and Technology
(Division of Chemistry)
Split
Defense date and country2016-09-29, Croatia
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Pharmacy
Abstract
Cilj istraživanja: Pronaći najbolje dostupne dokaze o učinkovitosti probiotika u prevenciji alergijskih bolesti i preosjetljivosti na hranu. Materijal i metode: Pronađen je, na stranici Cochrane knjižnice, sustavni pregled „Probiotics in infants for prevention of allergic disease and food hypersensitivity“ koji je bio okosnica daljnjeg istraživanja. Zatim su pretražene baze podataka MEDLINE (PubMed), CENTRAL i DARE u potrazi za novim randomiziranim kontoliranim studijama i sustavnim pregledima, a prema jednakim ulaznim i izlaznim kriterijima koji su navedeni u Cochrane sustavnom pregledu. Nakon pretraživanja literature napravljena je procjena kvalitete Cochrane sustavnog pregleda i novih pronađenih sustavnih pregleda pomoću R-AMSTAR ljestvice. Rezultati: Prema Cochrane sustavnom pregledu, koji je poslužio kao okosnica daljnjeg istraživanja, nije utvrđena značajna razlika među skupinama od ukupno 2080 djece u incidenciji alergijskih bolesti; alergija na hranu, alergije na hranu potvrđene skin prick testom ili testom na specifični IgE, astme, alergijskog rinitisa, preosjetljivosti na proteine kravljeg mlijeka, alergije na proteine kravljeg mlijeka, i urtikarije. Međutim, meta-analiza pet studija je prijavila ishode za 1477 djece kod kojih je potvrđena značajna razlika u incidenciji ekcema među skupinama. Studije koje su koristile L. Rhamnosus pokazale su se najhomogeniziranijima u prijavljivanju dobrobitnih ishoda. Zatim su pretraživanjem literature pronađene četiri nove randomizirane kontrolirane studije koje su uključene u ovaj rad. Dvije demonstriraju da nije bilo razlike u incidenciji ijedne alergijske bolesti među skupinama dok dvije napominju da je uočena značajna redukcija u incidenciji ekcema kod djece koja su primala probiotike. Noviji sustavni pregledi pokazuju da se incidencija atopijskih bolesti i preosjetljivosti na hranu značajnije reducira jedino kada su probiotici bili primjenjeni prenatalno i postnatalno. Zaključak: Postoje naznake da bi probiotici mogli biti korisni u prevenciji ekcema i preosjetljivosti na hranu u djece ali da bi se donijeli čvrsti zaključci i određene preporuke potrebne su daljne randomizirane kontrolne studije sa optimalnim probiotiskim sojevima, doziranjem, tranjanjem intervencije i dugotrajnim praćenjem.
Abstract (english)
Diploma Thesis Title: Finding the evidence about efficacy and safety of probiotics for the prevention of allergy and food hypersensitivity in children: systematic review approach Objectives: Finding the best available evidence of efficacy of probiotics for the prevention of allergy and food hypersensitivity in children. Material and Methods: Systematic review „Probiotics in infants for prevention of allergic disease and food hypersensitivity“ was found by searching the Cochrane Library website. Furthermore, MEDLINE (PubMed), DARE and CENTRAL databases were searched in order to find new randomised controlled trials and systematic reviews, following the same criteria that were used in Cochrane systematic review. After the search for studies was done, quality assessment was made of all systematic reviews using R-AMSTAR tool. Results: According to the Cochrane systematic review, there was no significant difference between groups of 2080 infants in the incidence of allergic diseases including asthma, rinitis, food allergy, food allergy confirmed by skin prick test or specific IgE test, urticaria, cow milk protein hypersensitivity. However meta-analysis of five studies reporting the outcomes of 1477 infants found a significant reduction in infant eczema. Studies using L. rhamnosus have been the most homogenous in reporting beneficial outcomes. More research was done and four new RCT were included. Two have reported that there was no significant difference between groups in the incidence of any allergic diseases. On the other hand two have reported that there were significant reduction in eczema. More recent systematic reviews provide results that there was significant reduction in atopic diseases and food hypersensitivity only when probiotics were administered prenataly and postnataly. Conclusion: Based on the reviewed systematic reviews and randomized controlled trials, probiotics might be useful in prevention of eczema and food hypersensitivity, but there is insufficient evidence to recommend the addition of probiotics to infant feeds for prevention of allergic disease or food hypersensitivity.
Keywords
Keywords (english)
Languagecroatian
URN:NBNurn:nbn:hr:167:026167
Study programmeTitle: Pharmacy
Study programme type: university
Study level: integrated undergraduate and graduate
Academic / professional title: magistar/magistra farmacije (magistar/magistra farmacije)
Type of resourceText
File originBorn digital
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2016-11-24 11:39:53