Infectious diseases pose a great health threat globally. Throughout the history of civilizations, no state has been immune to the catastrophic consequences of epidemic outbreaks. Consequently it developed the awareness and need for international cooperation in the fight against infectious diseases. With the development of globalization, infectious diseases are developing, as well as theirs resistance to scientific methods of their prevention. From the very beginning HIV/AIDS represents great scientific, as well as social challenge facing the modern world. International health organizations and public health agencies continuously work on the development and improvement of international cooperation in raising awareness about the diseases themselves, but also improvement in general sanitary condition, especially in less developed countries. AIDS today is one of the largest epidemics in the world, which is posing a great challenge in further progress, development and the achievement of international 6 cooperation. Through this paper, the international cooperation achieved in the field of HIV/AIDS will be researched, analyzed and compared, and new threats and challenges will be identified. Epidemics of infectious diseases are not a phenomenon of the past, but they are present and the future, and the main question is whether we can keep pace in controlling them.