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Professional paper - Review paper
Prirođena citomegalovirusna infekcija
Medicina Fluminensis, 48 (2012), 1; 23-29. urn:nbn:hr:184:484364
Pernjak Pugel, Ester; Cekinović, Đurđica

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Pernjak Pugel, E. & Cekinović, Đ. (2012). Prirođena citomegalovirusna infekcija. Medicina Fluminensis, 48. (1), 23-29. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:484364

Pernjak Pugel, Ester and Đurđica Cekinović. "Prirođena citomegalovirusna infekcija." Medicina Fluminensis, vol. 48, no. 1, 2012, pp. 23-29. https://urn.nsk.hr/urn:nbn:hr:184:484364

Pernjak Pugel, Ester and Đurđica Cekinović. "Prirođena citomegalovirusna infekcija." Medicina Fluminensis 48, no. 1 (2012): 23-29. https://urn.nsk.hr/urn:nbn:hr:184:484364

Pernjak Pugel, E. and Cekinović, Đ. (2012) 'Prirođena citomegalovirusna infekcija', Medicina Fluminensis, 48(1), pp. 23-29. Available at: https://urn.nsk.hr/urn:nbn:hr:184:484364 (Accessed 22 May 2024)

Pernjak Pugel E, Cekinović Đ. Prirođena citomegalovirusna infekcija. Medicina Fluminensis [Internet]. 2012 March 01 [cited 2024 May 22];48(1):23-29. Available at: https://urn.nsk.hr/urn:nbn:hr:184:484364

E. Pernjak Pugel and Đ. Cekinović, "Prirođena citomegalovirusna infekcija", Medicina Fluminensis, vol. 48, no. 1, pp. 23-29, March 2012. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:484364. [Accessed: 22 May 2024]

Metadata
Title (croatian)Prirođena citomegalovirusna infekcija
Title (english)Congenital Cytomegalovirus Infection
AuthorEster Pernjak Pugel
AuthorĐurđica Cekinović
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (croatian)
Infekcija citomegalovirusom (CMV) najučestalija je prirođena virusna infekcija u ljudi i glavni je uzrok oštećenja mozga u perinatalnom razdoblju. Zbog nastanka encefalitisa i razvojnih oštećenja, kao posljedicu ima trajne neurološke poremećaje. Infekcija humanim citomegalovirusom (HCMV) kod većine osoba s normalnom funkcijom imunološkog sustava ne izaziva klinički manifesnu bolest. Zbog toga je infekcija HCMV-om u trudnoći često neprepoznata, što predstavlja dodatan rizik za razvoj kongenitalne infekcije HCMV-om. Uz to što virus ima direktan citopatski učinak na neurone tijekom razvoja, samo prisustvo virusa u moždanom parenhimu dovodi do aktivacije upalnih stanica domaćina i niza patohistoloških lezija koje odgovaraju nastanku encefalitisa. Zbog toga bi daljnja istraživanja trebala biti usmjerena na razvoj sigurnog i učinkovitog cjepiva i lijekova koji će smanjiti rizik infekcije majki, a u slučaju prijelaza virusa s majke na dijete imati mogućnost spriječiti razvoj kongenitalne infekcije CMV-om.
Abstract (english)
Cytomegalovirus (CMV) infection is the most common congenital viral infection in humans and the major cause of wide-spread encephalitis and developmental abnormalities of the newborn brain which can lead to several neurological consequences. Infection with the human CMV (HCMV) in patients with normal immune function does not cause a clinically manifest disease. As the HCMV infection in pregnancy is often unrecognized, it represents an additional risk for development of congenital HCMV infection. Beside the direct cytopathic effect of CMV on neurons during neurogenesis, the presence of the virus in brain parenchyme leads to the activation of host inflammatory response and development of pathohistological lesions. Therefore, further studies should be focused on development of safe and effective vaccines and drugs that will reduce the risk of maternal infection and in case of virus transfer from mother to child have the ability to prevent the development of congenital CMV infection.
Keywords (croatian)
Keywords (english)
Languagecroatian
Publication typeProfessional paper - Review paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleMedicina Fluminensis
Numberingvol. 48, no. 1, pp. 23-29
p-ISSN0025-7729
URN:NBNurn:nbn:hr:184:484364
Publication2012-03-01
ProjectNumber: 062-0621261-1269
Title (croatian): Perinatalni citomegalovirusni encefalitis
Leader: Pernjak-Pugel, Ester
Jurisdiction: Croatia
Document URLhttp://hrcak.srce.hr/80227
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2017-05-10 10:40:37