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Professional paper - Review paper
MEHANIZMI DESTRUKCIJE HRSKAVICE I KOSTI U REUMATOIDNOM ARTRITISU
Medicina, 40 (2003), 2; 71-76. urn:nbn:hr:184:784999
Ravlić-Gulan, Jagoda; Gulan, Gordan; Rubinić, Dušan; Matovinović, Damir; Nemec, Boris

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Ravlić Gulan, J., Gulan, G., Rubinić, D., Matovinović, D. & Nemec, B. (2003). MEHANIZMI DESTRUKCIJE HRSKAVICE I KOSTI U REUMATOIDNOM ARTRITISU. Medicina, 40. (2), 71-76. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:784999

Ravlić Gulan, Jagoda, et al. "MEHANIZMI DESTRUKCIJE HRSKAVICE I KOSTI U REUMATOIDNOM ARTRITISU." Medicina, vol. 40, no. 2, 2003, pp. 71-76. https://urn.nsk.hr/urn:nbn:hr:184:784999

Ravlić Gulan, Jagoda, Gordan Gulan, Dušan Rubinić, Damir Matovinović and Boris Nemec. "MEHANIZMI DESTRUKCIJE HRSKAVICE I KOSTI U REUMATOIDNOM ARTRITISU." Medicina 40, no. 2 (2003): 71-76. https://urn.nsk.hr/urn:nbn:hr:184:784999

Ravlić Gulan, J., et al. (2003) 'MEHANIZMI DESTRUKCIJE HRSKAVICE I KOSTI U REUMATOIDNOM ARTRITISU', Medicina, 40(2), pp. 71-76. Available at: https://urn.nsk.hr/urn:nbn:hr:184:784999 (Accessed 04 May 2024)

Ravlić Gulan J, Gulan G, Rubinić D, Matovinović D, Nemec B. MEHANIZMI DESTRUKCIJE HRSKAVICE I KOSTI U REUMATOIDNOM ARTRITISU. Medicina [Internet]. 2003 [cited 2024 May 04];40(2):71-76. Available at: https://urn.nsk.hr/urn:nbn:hr:184:784999

J. Ravlić Gulan, G. Gulan, D. Rubinić, D. Matovinović and B. Nemec, "MEHANIZMI DESTRUKCIJE HRSKAVICE I KOSTI U REUMATOIDNOM ARTRITISU", Medicina, vol. 40, no. 2, pp. 71-76, 2003. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:784999. [Accessed: 04 May 2024]

Metadata
Title (croatian)MEHANIZMI DESTRUKCIJE HRSKAVICE I KOSTI U REUMATOIDNOM ARTRITISU
Title (english)MECHANISMS OF CARTILAGE AND BONE DESTRUCTION IN RHEUMATOID ARTHRITIS
AuthorJagoda Ravlić-Gulan
AuthorGordan Gulan
AuthorDušan Rubinić
AuthorDamir Matovinović
AuthorBoris Nemec
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Orthopedics and Physical Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Orthopedics
Abstract (croatian)
Reumatoidni artritis (RA) sistemska je, progresivna, kronična, upalna i autoimuna bolest zglobova koja dovodi do ireverzibilnih oštećenja zglobnih struktura i uzrokuje tešku invalidnost. Usprkos intenzivnim istraživanjima, patogenetski mehanizam bolesti još nije sasvim razjašnjen, ali se pretpostavlja da različiti putovi nastanka bolesti vode u zajednički put destrukcije zglobova. U ovome preglednom članku opisani su važniji stanični i molekularni mehanizmi destrukcije zglobnih struktura tijekom razvoja RA. Pritom su navedene meðustanične interakcije koje dovode do neravnoteže odnosa matriks metaloproteinaza i njihovih inhibitora. Opisan je i izravan molekularni model destrukcije kosti koji uključuje neravnotežu membranskih i solubilnih liganada koji se izražavaju na stanicama koštanog i imunološkog sustava, štoo konačno dovodi do poticanja sazrijevanja osteoklasta i resorpcije kosti. Razjašnjavanje molekularnih patogenetskih mehanizama destrukcije hrskavice i kosti svakako će pridonijeti pronalasku novih i specifičnih farmakoterapijskih pristupa u liječenju RA.
Abstract (english)
Rheumatoid arthritis (RA) is a systemic, progressive, chronic, inflammatory and autoimmune joint disease in which substantial irreversible joint destruction and severe functional disability occur. In spite of intensive research efforts in the field of RA, pathogenic mechanism remains incompletely understood. It is likely that disperate disease courses converge into a common route of joint destruction. In this review, some potential cellular and molecular mechanisms involved in joint destruction during the course of rheumatoid arthritis are described. Disturbed intercellular interactions which could result in overproduction of matrix metalloproteinases in comparison to their inhibitors are summarized. A direct molecular mechanism in which stimulation of osteoclastogenesis and bone resorption was explained by disbalance of distinct membrane-bound and solubile ligands, expressed simultaneously on bone and immune cells, has also been described. The continuing elucidation of pathophysiological pathways relevant in RA, offer substantional hope for the continued development of specific pharmacotherapy for the treatment of RA.
Keywords (croatian)
Keywords (english)
Languagecroatian
Publication typeProfessional paper - Review paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleMedicina
Numberingvol. 40, no. 2, pp. 71-76
p-ISSN0025-7729
URN:NBNurn:nbn:hr:184:784999
Publication2003
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2017-06-06 14:14:30