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Professional paper - Review paper
PRIMJENA TEHNIKA MOLEKULARNE CITOGENETIKE U DETEKCIJI KROMOSOMSKIH PROMJENA
Medicina, 42(40) (2004), 4; 247-255. urn:nbn:hr:184:749526
Vraneković, Jadranka

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Vraneković, J. (2004). PRIMJENA TEHNIKA MOLEKULARNE CITOGENETIKE U DETEKCIJI KROMOSOMSKIH PROMJENA. Medicina, 42(40). (4), 247-255. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:749526

Vraneković, Jadranka. "PRIMJENA TEHNIKA MOLEKULARNE CITOGENETIKE U DETEKCIJI KROMOSOMSKIH PROMJENA." Medicina, vol. 42(40), no. 4, 2004, pp. 247-255. https://urn.nsk.hr/urn:nbn:hr:184:749526

Vraneković, Jadranka. "PRIMJENA TEHNIKA MOLEKULARNE CITOGENETIKE U DETEKCIJI KROMOSOMSKIH PROMJENA." Medicina 42(40), no. 4 (2004): 247-255. https://urn.nsk.hr/urn:nbn:hr:184:749526

Vraneković, J. (2004) 'PRIMJENA TEHNIKA MOLEKULARNE CITOGENETIKE U DETEKCIJI KROMOSOMSKIH PROMJENA', Medicina, 42(40)(4), pp. 247-255. Available at: https://urn.nsk.hr/urn:nbn:hr:184:749526 (Accessed 20 May 2024)

Vraneković J. PRIMJENA TEHNIKA MOLEKULARNE CITOGENETIKE U DETEKCIJI KROMOSOMSKIH PROMJENA. Medicina [Internet]. 2004 [cited 2024 May 20];42(40)(4):247-255. Available at: https://urn.nsk.hr/urn:nbn:hr:184:749526

J. Vraneković, "PRIMJENA TEHNIKA MOLEKULARNE CITOGENETIKE U DETEKCIJI KROMOSOMSKIH PROMJENA", Medicina, vol. 42(40), no. 4, pp. 247-255, 2004. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:749526. [Accessed: 20 May 2024]

Metadata
Title (croatian)PRIMJENA TEHNIKA MOLEKULARNE CITOGENETIKE U DETEKCIJI KROMOSOMSKIH PROMJENA
Title (english)MOLECULAR BIOLOGY TECHNIQUES IN DETECTION OF CHROMOSOME CHANGES
AuthorJadranka Vraneković
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Biology and Medical Genetics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Human Genetics, Genomics and Proteomics
Abstract (croatian)
Krajem prošloga stoljeća humana je citogenetika uvođenjem tehnika molekularne biologije doživjela velik napredak, čime je omogućen razvoj molekularne citogenetike. Metode kao što su fluorescentna in situ hibridizacija (FISH), višebojna kariotipizacija (M-FISH, SKY, RXFISH) i komparativna hibridizacija genoma (CGH) riješile su nedostatke klasičnih metoda citogenetike, kojima se često nije mogao precizno opisati kariotip. Klinička primjena ovih metoda važna je u dijagnostici numeričkih i strukturnih promjena kromosoma kao što su trisomije, mikrodelecije, subtelomerne translokacije, te u identifikaciji podrijetla marker-kromosoma i promjena gena u tumorskim stanicama
Abstract (english)
By the end of last century, human cytogenetics experienced a remarkable progress by applying molecular biology techniques to the conventional chromosome analysis, and, in that way, a new discipline was established – molecular cytogenetics. The limitations of the conventional banding analysis in the accurate karyotyping and interpretation of certain chromosome abnormalities were largely overcome by these new technologies, such as, fluorescence in situ hybridisation (FISH), multicolour FISH (M-FISH, SKY, RXFISH) and comparative genomic hybridisation (CGH). The clinical applications include the diagnosis of numerical and structural aberrations (trisomy, microdeletion, subtelomeric translocations), as well as the identification of marker chromosomes and gene rearrangements in tumours.
Keywords (croatian)
Keywords (english)
Languagecroatian
Publication typeProfessional paper - Review paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleMedicina
Numberingvol. 42(40), no. 4, pp. 247-255
p-ISSN0025-7729
URN:NBNurn:nbn:hr:184:749526
Publication2004
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2017-06-09 13:12:55