prikaz prve stranice dokumenta Activation of Innate and Adaptive Immunity by a Recombinant Human Cytomegalovirus Strain Expressing an NKG2D Ligand.
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Scientific paper - Original scientific paper
Activation of Innate and Adaptive Immunity by a Recombinant Human Cytomegalovirus Strain Expressing an NKG2D Ligand.
PLoS Pathogens, 12 (2016), 12; :e1006015. https://doi.org/10.1371/journal.ppat.1006015.
Tomić, Adriana; Varanasi, Pavankumar R.; Golemac, Mijo; Malić, Suzana; Riese, Peggy; Mischak-Weissinger, Eva; Guzman, CA; Krmpotić, Astrid; Jonjić, Stipan; Messerle, Martin

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Tomić, A., Varanasi, P. R., Golemac, M., Malić, S., Riese, P., Mischak Weissinger, E. ... Messerle, M. (2016). Activation of Innate and Adaptive Immunity by a Recombinant Human Cytomegalovirus Strain Expressing an NKG2D Ligand.. PLoS Pathogens, 12. (12). doi: 10.1371/journal.ppat.1006015.

Tomić, Adriana, et al. "Activation of Innate and Adaptive Immunity by a Recombinant Human Cytomegalovirus Strain Expressing an NKG2D Ligand.." PLoS Pathogens, vol. 12, no. 12, 2016. https://doi.org/10.1371/journal.ppat.1006015.

Tomić, Adriana, Pavankumar R. Varanasi, Mijo Golemac, Suzana Malić, Peggy Riese, Eva Mischak Weissinger, CA Guzman, Astrid Krmpotić, Stipan Jonjić and Martin Messerle. "Activation of Innate and Adaptive Immunity by a Recombinant Human Cytomegalovirus Strain Expressing an NKG2D Ligand.." PLoS Pathogens 12, no. 12 (2016). https://doi.org/10.1371/journal.ppat.1006015.

Tomić, A., et al. (2016) 'Activation of Innate and Adaptive Immunity by a Recombinant Human Cytomegalovirus Strain Expressing an NKG2D Ligand.', PLoS Pathogens, 12(12). doi: 10.1371/journal.ppat.1006015.

Tomić A, Varanasi PR, Golemac M, Malić S, Riese P, Mischak Weissinger E, and sur.. Activation of Innate and Adaptive Immunity by a Recombinant Human Cytomegalovirus Strain Expressing an NKG2D Ligand.. PLoS Pathogens [Internet]. 2016 [cited 2024 May 14];12(12). doi: 10.1371/journal.ppat.1006015.

A. Tomić, et al., "Activation of Innate and Adaptive Immunity by a Recombinant Human Cytomegalovirus Strain Expressing an NKG2D Ligand.", PLoS Pathogens, vol. 12, no. 12, 2016. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:183434. [Accessed: 14 May 2024]

Metadata
Title (english)Activation of Innate and Adaptive Immunity by a Recombinant Human Cytomegalovirus Strain Expressing an NKG2D Ligand.
AuthorAdriana Tomić
AuthorPavankumar R. Varanasi
AuthorMijo Golemac
AuthorSuzana Malić
AuthorPeggy Riese
AuthorEva Mischak-Weissinger
AuthorCA Guzman
AuthorAstrid Krmpotić
AuthorStipan Jonjić
AuthorMartin Messerle
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Development of an effective vaccine against human cytomegalovirus (HCMV) is a need of utmost medical importance. Generally, it is believed that a live attenuated vaccine would best provide protective immunity against this tenacious pathogen. Here, we propose a strategy for an HCMV vaccine that aims at the simultaneous activation of innate and adaptive immune responses. An HCMV strain expressing the host ligand ULBP2 for the NKG2D receptor was found to be susceptible to control by natural killer (NK) cells, and preserved the ability to stimulate HCMV-specific T cells. Infection with the ULBP2-expressing HCMV strain caused diminished cell surface levels of MHC class I molecules. While expression of the NKG2D ligand increased the cytolytic activity of NK cells, NKG2D engagement in CD8+ T cells provided co-stimulation and compensated for lower MHC class I expression. Altogether, our data indicate that triggering of both arms of the immune system is a promising approach applicable to the generation of a live attenuated HCMV vaccine.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titlePLoS Pathogens
Numberingvol. 12, no. 12, :e1006015
p-ISSN1553-7366
e-ISSN1553-7374
DOIhttps://doi.org/10.1371/journal.ppat.1006015.
URN:NBNurn:nbn:hr:184:183434
Publication2016
ProjectNumber: 322693
Title (english): Strengthening adaptive immunity via innate immunity: enhancing the CD8 T cell response by using the NKG2D ligand expressed in a herpesvirus vector
Acronym: STADVINN
Jurisdiction: eu
Funding stream: FP7
Document URLournals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1006015
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2017-06-23 13:15:00