INTRODUCTION: Multiple myeloma is an incurable malignancy of plasma cells, manifested by bone marrow infiltration, change in the microenvironment and the development of appropriate clinical presentation. MATERIALS AND METHODS: Descriptive analysis of data related to the type of myeloma and light chains, anemia, CRP, creatinine, calcium, LDH, staging system by DS and ISS, the presence of bone pain, bone pathology and finally comparison of bone pathology and hypercalcemia with response to therapy and survival. Of the 98 patients included in the study, 51 patients (52%) were male and 47 (48%) of patients were female. Median follow-up was 17 months, a minimum of 1 month and a maximum of 71 months.. The data were processed in the Statistica software Stat12, and Microsoft Excel2007. For analysis of categorical variables was used Fisher's exact test and Chi-square. RESULTS: The predominant immunoglobulin class was IgG, and kappa for the light chain class. From laboratory results dominant finding was anemia (54 patients, 59%). According to DS staging system, the highest number of patients were 2A staged (30 patients), and according to ISS system, the dominant stage was stage 3 (37 patients). Pain was present in 44 patients (53%), while the bone pathology had the highest incidence of pathological fractures in 51 patients. No significant difference was found in the response to treatment and survival in groups of patients with bone disease and hypercalcemia. DISCUSSION: The obtained results correspond to literature findings of other studies, while in the case of bone disease and hypercalcemia, significant association has not been found with response to treatment and survival.