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Professional paper - Review paper
Geni i celijakija
Paediatria Croatica, 59 (2015), 2; 89-94. https://doi.org/10.13112/PC.2015.14
Starčević Čizmarević, Nada; Mijandrušić-Sinčić, Brankica; Licul, Vanja; Kapović, Miljenko; Ristić, Smiljana

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Starčević Čizmarević, N., Mijandrušić Sinčić, B., Licul, V., Kapović, M. & Ristić, S. (2015). Geni i celijakija. Paediatria Croatica, 59. (2), 89-94. doi: 10.13112/PC.2015.14

Starčević Čizmarević, Nada, et al. "Geni i celijakija." Paediatria Croatica, vol. 59, no. 2, 2015, pp. 89-94. https://doi.org/10.13112/PC.2015.14

Starčević Čizmarević, Nada, Brankica Mijandrušić Sinčić, Vanja Licul, Miljenko Kapović and Smiljana Ristić. "Geni i celijakija." Paediatria Croatica 59, no. 2 (2015): 89-94. https://doi.org/10.13112/PC.2015.14

Starčević Čizmarević, N., et al. (2015) 'Geni i celijakija', Paediatria Croatica, 59(2), pp. 89-94. doi: 10.13112/PC.2015.14

Starčević Čizmarević N, Mijandrušić Sinčić B, Licul V, Kapović M, Ristić S. Geni i celijakija. Paediatria Croatica [Internet]. 2015 June 26 [cited 2024 November 22];59(2):89-94. doi: 10.13112/PC.2015.14

N. Starčević Čizmarević, B. Mijandrušić Sinčić, V. Licul, M. Kapović and S. Ristić, "Geni i celijakija", Paediatria Croatica, vol. 59, no. 2, pp. 89-94, June 2015. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:403696. [Accessed: 22 November 2024]

Metadata
Title (croatian)Geni i celijakija
Title (english)Genes and celiac disease
AuthorNada Starčević Čizmarević
AuthorBrankica Mijandrušić-Sinčić
AuthorVanja Licul
AuthorMiljenko Kapović
AuthorSmiljana Ristić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Biology and Medical Genetics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Human Genetics, Genomics and Proteomics
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (croatian)
Celijakija je bolest poremećenog imunosnog odgovora potaknutog glutenom koja se javlja u genetički predisponiranih osoba. Svrha ovog rada je prikazati dosadašnje spoznaje iz genetike celijakije. Genska podloga celijakije vezana za lokus humanih leukocitnih antigena kao dominantnog genetičkog elementa detaljno je razjašnjena. No postoji i velik broj gena izvan ove regije koji pridonose etiopatogenezi bolesti, a samo su dijelom zajednički pojedinim bolesnicima, što upućuje na genetičku heterogenost bolesti. Uz to je opaženo da su mnogi od tih rizičnih lokusa u celijakiji zajednički s lokusima za druge autoimunosne bolesti. Značajan doprinos novim spoznajama daju recentne cjelogenomske asocijacijske studije, ali tek treba istražiti velik dio još i sad nepoznate heritabilnosti u celijakiji.
Abstract (english)
Celiac disease is a chronic infl ammatory disease of the small intestine triggered by gluten intake, which occurs in genetically susceptible individuals. The purpose of this paper is to present recent fi ndings in the genetics of celiac disease. Genetic background of celiac disease related to human leukocyte antigen locus (HLA) as a dominant genetic element has been well described. However, the existence of a large number of non-HLA celiac disease genes, only partly shared by each individual patient, suggests genetic heterogeneity of the disease. In addition, it has been observed that many of these risk loci in celiac disease are common with the loci for other autoimmune diseases. A signifi cant contribution to our knowledge has been provided by recent genome-wide association studies, but great part of the still unknown heritability in celiac disease is yet to be explored in the future.
Keywords (croatian)
Keywords (english)
Languagecroatian
Publication typeProfessional paper - Review paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titlePaediatria Croatica
Numberingvol. 59, no. 2, pp. 89-94
p-ISSN1330-1403
e-ISSN1846-405X
DOIhttps://doi.org/10.13112/PC.2015.14
URN:NBNurn:nbn:hr:184:403696
Publication2015-06-26
Document URLhttp://hrcak.srce.hr/142554
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2017-07-11 15:38:54