prikaz prve stranice dokumenta Angiotensin-converting enzyme insertion/deletion gene polymorphism in multiple sclerosis: a meta-analysis
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Scientific paper - Original scientific paper
Angiotensin-converting enzyme insertion/deletion gene polymorphism in multiple sclerosis: a meta-analysis
Neurological Sciences, 37 (2016), 12; 1955-1959. https://doi.org/10.1007/s10072-016-2698-3
Ristić, Smiljana; Starčević-Čizmarević, Nada; Sepčić, Juraj; Kapović, Miljenko; Peterlin, Borut

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Ristić, S., Starčević Čizmarević, N., Sepčić, J., Kapović, M. & Peterlin, B. (2016). Angiotensin-converting enzyme insertion/deletion gene polymorphism in multiple sclerosis: a meta-analysis. Neurological Sciences, 37. (12), 1955-1959. doi: 10.1007/s10072-016-2698-3

Ristić, Smiljana, et al. "Angiotensin-converting enzyme insertion/deletion gene polymorphism in multiple sclerosis: a meta-analysis." Neurological Sciences, vol. 37, no. 12, 2016, pp. 1955-1959. https://doi.org/10.1007/s10072-016-2698-3

Ristić, Smiljana, Nada Starčević Čizmarević, Juraj Sepčić, Miljenko Kapović and Borut Peterlin. "Angiotensin-converting enzyme insertion/deletion gene polymorphism in multiple sclerosis: a meta-analysis." Neurological Sciences 37, no. 12 (2016): 1955-1959. https://doi.org/10.1007/s10072-016-2698-3

Ristić, S., et al. (2016) 'Angiotensin-converting enzyme insertion/deletion gene polymorphism in multiple sclerosis: a meta-analysis', Neurological Sciences, 37(12), pp. 1955-1959. doi: 10.1007/s10072-016-2698-3

Ristić S, Starčević Čizmarević N, Sepčić J, Kapović M, Peterlin B. Angiotensin-converting enzyme insertion/deletion gene polymorphism in multiple sclerosis: a meta-analysis. Neurological Sciences [Internet]. 2016 August 27 [cited 2024 November 22];37(12):1955-1959. doi: 10.1007/s10072-016-2698-3

S. Ristić, N. Starčević Čizmarević, J. Sepčić, M. Kapović and B. Peterlin, "Angiotensin-converting enzyme insertion/deletion gene polymorphism in multiple sclerosis: a meta-analysis", Neurological Sciences, vol. 37, no. 12, pp. 1955-1959, August 2016. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:838233. [Accessed: 22 November 2024]

Metadata
Title (english)Angiotensin-converting enzyme insertion/deletion gene polymorphism in multiple sclerosis: a meta-analysis
AuthorSmiljana Ristić
AuthorNada Starčević-Čizmarević
AuthorJuraj Sepčić
AuthorMiljenko Kapović
AuthorBorut Peterlin
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Biology and Medical Genetics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Human Genetics, Genomics and Proteomics
Abstract (english)
The activity of angiotensin-converting enzyme (ACE) has been increased in the blood and cerebrospinal fluid of multiple sclerosis (MS) patients. In addition, there has been suppression of disease development in experimental autoimmune encephalomyelitis after blockade of ACE. These findings suggest that ACE may play a role in the MS pathogenesis. Since the previous studies investigating the association between the insertion/deletion (I/D) polymorphism in intron 16 of the ACE gene and MS reported contradictory results, we performed a meta-analysis of four studies conducted in European populations of Slavic origin (1062 patients and 1067 controls) using the Comprehensive Meta-analysis 3.0 software. The results demonstrated that the ACE I/D polymorphism had no statistically significant association with an increased MS risk (all p aeyen 0.05) under all genetic comparison models: (1) allelic (D vs. I), (2) recessive (DD vs. ID + II), (3) dominant (DD + ID vs. II), and (4) additive (DD vs. ID vs. II). This meta-analysis indicates that the ACE I/D polymorphism is not associated with susceptibility to MS in Europeans of Slavic origin. Further studies with larger sample sizes from genetically different populations are warranted.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleNeurological Sciences
Numberingvol. 37, no. 12, pp. 1955-1959
p-ISSN1590-1874
e-ISSN1590-3478
DOIhttps://doi.org/10.1007/s10072-016-2698-3
URN:NBNurn:nbn:hr:184:838233
Online first2016-08-27
Document URLhttps://link.springer.com/article/10.1007/s10072-016-2698-3
Type of resourceText
Access conditionsClosed access
Terms of useLicence In copyright icon
Created on2017-08-01 10:07:31