prikaz prve stranice dokumenta Angiotensin-Converting Enzyme Insertion/Deletion Gene Polymorphism in Lung Cancer Patients
No public access
Scientific paper - Original scientific paper
Angiotensin-Converting Enzyme Insertion/Deletion Gene Polymorphism in Lung Cancer Patients
Genetic Testing and Molecular Biomarkers, 16 (2012), 7; 722-725. https://doi.org/10.1089/gtmb.2011.0306
Dević Pavlić, Sanja; Ristić, Smiljana; Flego, Veljko; Kapović, Miljenko; Radojčić Badovinac, Anđelka

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

Cite this document

Dević Pavlić, S., Ristić, S., Flego, V., Kapović, M. & Radojčić Badovinac, A. (2012). Angiotensin-Converting Enzyme Insertion/Deletion Gene Polymorphism in Lung Cancer Patients. Genetic Testing and Molecular Biomarkers, 16. (7), 722-725. doi: 10.1089/gtmb.2011.0306

Dević Pavlić, Sanja, et al. "Angiotensin-Converting Enzyme Insertion/Deletion Gene Polymorphism in Lung Cancer Patients." Genetic Testing and Molecular Biomarkers, vol. 16, no. 7, 2012, pp. 722-725. https://doi.org/10.1089/gtmb.2011.0306

Dević Pavlić, Sanja, Smiljana Ristić, Veljko Flego, Miljenko Kapović and Anđelka Radojčić Badovinac. "Angiotensin-Converting Enzyme Insertion/Deletion Gene Polymorphism in Lung Cancer Patients." Genetic Testing and Molecular Biomarkers 16, no. 7 (2012): 722-725. https://doi.org/10.1089/gtmb.2011.0306

Dević Pavlić, S., et al. (2012) 'Angiotensin-Converting Enzyme Insertion/Deletion Gene Polymorphism in Lung Cancer Patients', Genetic Testing and Molecular Biomarkers, 16(7), pp. 722-725. doi: 10.1089/gtmb.2011.0306

Dević Pavlić S, Ristić S, Flego V, Kapović M, Radojčić Badovinac A. Angiotensin-Converting Enzyme Insertion/Deletion Gene Polymorphism in Lung Cancer Patients. Genetic Testing and Molecular Biomarkers [Internet]. 2012 [cited 2024 April 30];16(7):722-725. doi: 10.1089/gtmb.2011.0306

S. Dević Pavlić, S. Ristić, V. Flego, M. Kapović and A. Radojčić Badovinac, "Angiotensin-Converting Enzyme Insertion/Deletion Gene Polymorphism in Lung Cancer Patients", Genetic Testing and Molecular Biomarkers, vol. 16, no. 7, pp. 722-725, 2012. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:100694. [Accessed: 30 April 2024]

Metadata
Title (english)Angiotensin-Converting Enzyme Insertion/Deletion Gene Polymorphism in Lung Cancer Patients
AuthorSanja Dević Pavlić
AuthorSmiljana Ristić
AuthorVeljko Flego
AuthorMiljenko Kapović
AuthorAnđelka Radojčić Badovinac
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Biology and Medical Genetics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Human Genetics, Genomics and Proteomics
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Abstract (english)
Lung cancer is a complex disease, and many factors, including environmental and occupational exposure, cigarette smoking, and genetics, contribute to its progression. Angiotensin-converting enzyme (ACE) is an important regulator of blood pressure and cardiovascular homeostasis. Plasma levels of ACE depend on an insertion/deletion (I/D) polymorphism in its gene. Current correlation data between lung cancer and the ACE I/D polymorphism are contradictory or insufficient. We investigated whether the ACE I/D polymorphism is associated with a risk for lung cancer development in the Croatian population, representing the first report in a population of Slavic origin. A total of 308 lung cancer patients and 353 control subjects were genotyped for the ACE I/D polymorphism by polymerase chain reaction. The observed distribution of genotypes and alleles showed no significant difference between total patients and controls (p>0.050). However, in a subgroup of nonsmall cell lung cancer patients with squamous cell carcinoma, a significantly higher frequency of the DD genotype (37.7% vs. 27.8%, p=0.030, OR=1.57, 95% CI=1.05–2.36) and D allele was observed compared with the control group (61.3% vs. 52.8%, p=0.015, OR=1.41, 95% CI=1.07–1.87). The DD genotype of ACE may contribute to a higher risk of developing squamous cell carcinoma in the Croatian population.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleGenetic Testing and Molecular Biomarkers
Numberingvol. 16, no. 7, pp. 722-725
p-ISSN1945-0265
e-ISSN1945-0257
DOIhttps://doi.org/10.1089/gtmb.2011.0306
URN:NBNurn:nbn:hr:184:100694
Publication2012
Document URLhttps://doi.org/10.1089/gtmb.2011.0306
Type of resourceText
Access conditionsClosed access
Terms of useLicence In copyright icon
Created on2017-08-02 10:20:01