prikaz prve stranice dokumenta Primary lung cancer and TNF-a gene polymorphisms: A case-control study in a Croatian population
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Scientific paper - Original scientific paper
Primary lung cancer and TNF-a gene polymorphisms: A case-control study in a Croatian population
Medical science monitor, 15 (2009), 7; 361-365. urn:nbn:hr:184:337341
Flego, Veljko; Radojčić Badovinac, Anđelka; Bulat-Kardum, Ljiljana; Matanić, Dubravka; Crnić-Martinović, Marija; Kapović, Miljenko; Ristić, Smiljana

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Flego, V., Radojčić Badovinac, A., Bulat Kardum, Lj., Matanić, D., Crnić Martinović, M., Kapović, M. & Ristić, S. (2009). Primary lung cancer and TNF-a gene polymorphisms: A case-control study in a Croatian population. Medical science monitor, 15. (7), 361-365. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:337341

Flego, Veljko, et al. "Primary lung cancer and TNF-a gene polymorphisms: A case-control study in a Croatian population." Medical science monitor, vol. 15, no. 7, 2009, pp. 361-365. https://urn.nsk.hr/urn:nbn:hr:184:337341

Flego, Veljko, Anđelka Radojčić Badovinac, Ljiljana Bulat Kardum, Dubravka Matanić, Marija Crnić Martinović, Miljenko Kapović and Smiljana Ristić. "Primary lung cancer and TNF-a gene polymorphisms: A case-control study in a Croatian population." Medical science monitor 15, no. 7 (2009): 361-365. https://urn.nsk.hr/urn:nbn:hr:184:337341

Flego, V., et al. (2009) 'Primary lung cancer and TNF-a gene polymorphisms: A case-control study in a Croatian population', Medical science monitor, 15(7), pp. 361-365. Available at: https://urn.nsk.hr/urn:nbn:hr:184:337341 (Accessed 22 November 2024)

Flego V, Radojčić Badovinac A, Bulat Kardum Lj, Matanić D, Crnić Martinović M, Kapović M, and sur.. Primary lung cancer and TNF-a gene polymorphisms: A case-control study in a Croatian population. Medical science monitor [Internet]. 2009 [cited 2024 November 22];15(7):361-365. Available at: https://urn.nsk.hr/urn:nbn:hr:184:337341

V. Flego, et al., "Primary lung cancer and TNF-a gene polymorphisms: A case-control study in a Croatian population", Medical science monitor, vol. 15, no. 7, pp. 361-365, 2009. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:337341. [Accessed: 22 November 2024]

Metadata
Title (english)Primary lung cancer and TNF-a gene polymorphisms: A case-control study in a Croatian population
AuthorVeljko Flego
AuthorAnđelka Radojčić Badovinac
AuthorLjiljana Bulat-Kardum
AuthorDubravka Matanić
AuthorMarija Crnić-Martinović
AuthorMiljenko Kapović
AuthorSmiljana Ristić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Biology and Medical Genetics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Internal Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Human Genetics, Genomics and Proteomics
Abstract (english)
Tumor necrosis factor-a (TNF-a) is a multifunctional cytokine involved in the pathogenesis of various infl ammatory and malignant diseases. Previous studies investigating the role of the TNF-a gene polymorphisms in lung cancer have generated contradictory results. The present study investigated whether the TNF-a-308 and TNF-a-238 polymorphisms are associated with risk and/or severity of disease in Croatian lung cancer patients. This is the fi rst study in a Caucasian population to analyze the infl uence of these two polymorphisms on multiple types of lung cancer. Material/Methods: In a case-control study, lung cancer patients (n=230) and appropriate age- and sex-matched controls (n=230) were genotyped by the polymerase chain reaction/restriction fragment length polymorphism method. Allele and genotype frequencies were estimated by gene counting. The chisquared test was used to compare the observed numbers of different TNF-a genotypes for the population with those predicted by Hardy-Weinberg equilibrium. Differences in genotype and allele distributions in the patient and control groups were analyzed for statistical signifi cance using the chi-squared test or Fisher’s exact test as appropriate. Results: There were no signifi cant differences in the genotype and allele frequencies for the TNF-a-308 and TNF-a-238 polymorphisms between lung cancer patients and controls. Furthermore, no association between the genotypes and different stages of lung cancer was detected. Conclusions: This study indicates that the TNF-a-308 and TNF-a-238 polymorphisms do not infl uence susceptibility to or severity of lung cancer in a Croatian population.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleMedical science monitor
Numberingvol. 15, no. 7, pp. 361-365
e-ISSN1643-3750
URN:NBNurn:nbn:hr:184:337341
Publication2009
Document URLhttp://www.medscimonit.com/fulltxt.php?ICID=869711
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2017-08-03 06:11:56