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Scientific paper - Review paper
Molecular and Genetic Mechanisms in Melanoma
Collegium antropologicum, 32 - Supplement 2 (2008), 2; 147-152. urn:nbn:hr:184:713311
Gruber, Franjo; Kaštelan, Marija; Brajac, Ines; Saftić, Marina; Peharda, Vesna; Čabrijan, Leo; Stanić Žgombić, Zrinka; Simonić, Edita

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Gruber, F., Kaštelan, M., Brajac, I., Saftić, M., Peharda, V., Čabrijan, L. ... Simonić, E. (2008). Molecular and Genetic Mechanisms in Melanoma. Collegium antropologicum, 32 - Supplement 2. (2), 147-152. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:713311

Gruber, Franjo, et al. "Molecular and Genetic Mechanisms in Melanoma." Collegium antropologicum, vol. 32 - Supplement 2, no. 2, 2008, pp. 147-152. https://urn.nsk.hr/urn:nbn:hr:184:713311

Gruber, Franjo, Marija Kaštelan, Ines Brajac, Marina Saftić, Vesna Peharda, Leo Čabrijan, Zrinka Stanić Žgombić and Edita Simonić. "Molecular and Genetic Mechanisms in Melanoma." Collegium antropologicum 32 - Supplement 2, no. 2 (2008): 147-152. https://urn.nsk.hr/urn:nbn:hr:184:713311

Gruber, F., et al. (2008) 'Molecular and Genetic Mechanisms in Melanoma', Collegium antropologicum, 32 - Supplement 2(2), pp. 147-152. Available at: https://urn.nsk.hr/urn:nbn:hr:184:713311 (Accessed 28 December 2024)

Gruber F, Kaštelan M, Brajac I, Saftić M, Peharda V, Čabrijan L, and sur.. Molecular and Genetic Mechanisms in Melanoma. Collegium antropologicum [Internet]. 2008 October 01 [cited 2024 December 28];32 - Supplement 2(2):147-152. Available at: https://urn.nsk.hr/urn:nbn:hr:184:713311

F. Gruber, et al., "Molecular and Genetic Mechanisms in Melanoma", Collegium antropologicum, vol. 32 - Supplement 2, no. 2, pp. 147-152, October 2008. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:713311. [Accessed: 28 December 2024]

Metadata
Title (english)Molecular and Genetic Mechanisms in Melanoma
AuthorFranjo Gruber
AuthorMarija Kaštelan
AuthorInes Brajac
AuthorMarina Saftić
AuthorVesna Peharda
AuthorLeo Čabrijan
AuthorZrinka Stanić Žgombić
AuthorEdita Simonić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Dermatovenerology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Dermatovenerology
Abstract (english)
Recent studies have indicated an increasing incidence of melanoma worldwide. Although UV signature mutations are found rarely in melanoma cells, there is some evidence that intense intermittent exposure to sunlight can induce melanocyte tumorigenesis, and this is also observed after UV irradiation in some animals. The purpose of this paper is to review some of the most important mechanisms involved in the pathogenesis of this tumor. Genetic studies showed the familiar melanoma is linked to the mutation or deletion of the suppressor gene CDKN2A, and perhaps to CDK4. Studies showed that BRAF mutation is frequent in primary and metastatic melanoma cells but also in naevocytic nevi. This mutation activates the RAF/MEK pathway. Exposure to UV radiation induces immunosuppression. Recent investigations showed that chemokines, angiogenesis, metalloproteinases can play a role in the mechanism of metastasis. In spite of these advances the initiating events are still not completely understood. In conclusion, the pathogenesis of melanoma is very complex because numerous genetic and epigenetic factors are implicated in its development and progression, but some of the showed mechanisms can be targets for new therapies.
Keywords (english)
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCollegium antropologicum
Numberingvol. 32 - Supplement 2, no. 2, pp. 147-152
p-ISSN0350-6134
URN:NBNurn:nbn:hr:184:713311
Publication2008-10-01
Document URLhttp://hrcak.srce.hr/34642
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2017-08-08 11:14:16