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Scientific paper - Original scientific paper
A Viral Immunoevasin Controls Innate Immunity by Targeting the Prototypical Natural Killer Cell Receptor Family
Cell, 169 (2017), 1; 58-71. https://doi.org/10.1016/j.cell.2017.03.002
Aguilar, Oscar A.; Berry, R.; Rahim, M.; Reichel, J.; Popović, Branka; Tanaka, M.; Fu, Z.; Balaji, G.; Lau, T.; Tu, M.; Kirkham, C.; Mahmoud, A.; Mesci, A.; Krmpotić, Astrid; Allan, David S.J.; Makrigiannis, A.; Jonjić, Stipan; Rossjohn, J.; Carlyle, J. More authors...

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Aguilar, O. A., Berry, R., Rahim, M., Reichel, J., Popović, B., Tanaka, M. ... Carlyle, J. (2017). A Viral Immunoevasin Controls Innate Immunity by Targeting the Prototypical Natural Killer Cell Receptor Family. Cell, 169. (1), 58-71. doi: 10.1016/j.cell.2017.03.002

Aguilar, Oscar A., et al. "A Viral Immunoevasin Controls Innate Immunity by Targeting the Prototypical Natural Killer Cell Receptor Family." Cell, vol. 169, no. 1, 2017, pp. 58-71. https://doi.org/10.1016/j.cell.2017.03.002

Aguilar, Oscar A., R. Berry, M. Rahim, J. Reichel, Branka Popović, M. Tanaka, Z. Fu, et al. "A Viral Immunoevasin Controls Innate Immunity by Targeting the Prototypical Natural Killer Cell Receptor Family." Cell 169, no. 1 (2017): 58-71. https://doi.org/10.1016/j.cell.2017.03.002

Aguilar, O. A., et al. (2017) 'A Viral Immunoevasin Controls Innate Immunity by Targeting the Prototypical Natural Killer Cell Receptor Family', Cell, 169(1), pp. 58-71. doi: 10.1016/j.cell.2017.03.002

Aguilar OA, Berry R, Rahim M, Reichel J, Popović B, Tanaka M, and sur.. A Viral Immunoevasin Controls Innate Immunity by Targeting the Prototypical Natural Killer Cell Receptor Family. Cell [Internet]. 2017 [cited 2025 January 13];169(1):58-71. doi: 10.1016/j.cell.2017.03.002

O. A. Aguilar, et al., "A Viral Immunoevasin Controls Innate Immunity by Targeting the Prototypical Natural Killer Cell Receptor Family", Cell, vol. 169, no. 1, pp. 58-71, 2017. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:958538. [Accessed: 13 January 2025]

Metadata
Title (english)A Viral Immunoevasin Controls Innate Immunity by Targeting the Prototypical Natural Killer Cell Receptor Family
AuthorOscar A. Aguilar
AuthorR. Berry
AuthorM. Rahim
AuthorJ. Reichel
AuthorBranka Popović
AuthorM. Tanaka
AuthorZ. Fu
AuthorG. Balaji
AuthorT. Lau
AuthorM. Tu
AuthorC. Kirkham
AuthorA. Mahmoud
AuthorA. Mesci
AuthorAstrid Krmpotić
AuthorDavid S.J. Allan
AuthorA. Makrigiannis
AuthorStipan Jonjić
AuthorJ. Rossjohn
AuthorJ. Carlyle
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Natural killer (NK) cells play a key role in innate immunity by detecting alterations in self and non-self ligands via paired NK cell receptors (NKRs). Despite identification of numerous NKR-ligand interactions, physiological ligands for the prototypical NK1.1 orphan receptor remain elusive. Here, we identify a viral ligand for the inhibitory and activating NKRP1(NK1.1) receptors. This murine cytomegalovirus(MCMV)-encoded protein, m12, restrains NK cell effector function by directly engaging the inhibitory NKR-P1B receptor. However, m12 also interacts with the activating NKR-P1A/C receptors to counterbalance m12 decoy function. Structural analyses reveal that m12 sequesters a large NKR-P1 surface area via a ‘‘polar claw’’ mechanism. Polymorphisms in, and ablation of, the viral m12 protein and host NKR-P1B/C alleles impact NK cell responses in vivo. Thus, we identify the long-sought foreign ligand for this key immunoregulatory NKR family and reveal how it controls the evolutionary balance of immune recognition during host-pathogen interplay.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleCell
Numberingvol. 169, no. 1, pp. 58-71, e14
e-ISSN0092-8674
DOIhttps://doi.org/10.1016/j.cell.2017.03.002
URN:NBNurn:nbn:hr:184:958538
Publication2017
ProjectNumber: IP-2013-11-7132
Title (croatian): Aktivacijski receptori NK-stanica specifični za virus i njihovo izbjegavanje od strane virusa
Acronym: ViSpeNKRec
Leader: Astrid Krmpotić
Jurisdiction: Croatia
Funding stream: IP
ProjectNumber: 322693
Title (english): Strengthening adaptive immunity via innate immunity: enhancing the CD8 T cell response by using the NKG2D ligand expressed in a herpesvirus vector
Acronym: STADVINN
Jurisdiction: eu
Funding stream: FP7
Document URLhttp://www.sciencedirect.com/science/article/pii/S0092867417302507
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2017-08-23 08:56:22