prikaz prve stranice dokumenta Expression of Cell Cycle and Apoptosis Regulatory Proteins and Telomerase in Melanocitic Lesions
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Scientific paper - Original scientific paper
Expression of Cell Cycle and Apoptosis Regulatory Proteins and Telomerase in Melanocitic Lesions
Collegium antropologicum, 31 - Supplement 1 (2007), 1; 17-22. urn:nbn:hr:184:263269
Batinac, Tanja; Hadžisejdić, Ita; Brumini, Gordana; Ružić, Alen; Vojniković, Božidar; Zamolo, Gordana

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Batinac, T., Hadžisejdić, I., Brumini, G., Ružić, A., Vojniković, B. & Zamolo, G. (2007). Expression of Cell Cycle and Apoptosis Regulatory Proteins and Telomerase in Melanocitic Lesions. Collegium antropologicum, 31 - Supplement 1. (1), 17-22. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:263269

Batinac, Tanja, et al. "Expression of Cell Cycle and Apoptosis Regulatory Proteins and Telomerase in Melanocitic Lesions." Collegium antropologicum, vol. 31 - Supplement 1, no. 1, 2007, pp. 17-22. https://urn.nsk.hr/urn:nbn:hr:184:263269

Batinac, Tanja, Ita Hadžisejdić, Gordana Brumini, Alen Ružić, Božidar Vojniković and Gordana Zamolo. "Expression of Cell Cycle and Apoptosis Regulatory Proteins and Telomerase in Melanocitic Lesions." Collegium antropologicum 31 - Supplement 1, no. 1 (2007): 17-22. https://urn.nsk.hr/urn:nbn:hr:184:263269

Batinac, T., et al. (2007) 'Expression of Cell Cycle and Apoptosis Regulatory Proteins and Telomerase in Melanocitic Lesions', Collegium antropologicum, 31 - Supplement 1(1), pp. 17-22. Available at: https://urn.nsk.hr/urn:nbn:hr:184:263269 (Accessed 18 February 2025)

Batinac T, Hadžisejdić I, Brumini G, Ružić A, Vojniković B, Zamolo G. Expression of Cell Cycle and Apoptosis Regulatory Proteins and Telomerase in Melanocitic Lesions. Collegium antropologicum [Internet]. 2007 January 16 [cited 2025 February 18];31 - Supplement 1(1):17-22. Available at: https://urn.nsk.hr/urn:nbn:hr:184:263269

T. Batinac, I. Hadžisejdić, G. Brumini, A. Ružić, B. Vojniković and G. Zamolo, "Expression of Cell Cycle and Apoptosis Regulatory Proteins and Telomerase in Melanocitic Lesions", Collegium antropologicum, vol. 31 - Supplement 1, no. 1, pp. 17-22, January 2007. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:263269. [Accessed: 18 February 2025]

Metadata
Title (english)Expression of Cell Cycle and Apoptosis Regulatory Proteins and Telomerase in Melanocitic Lesions
AuthorTanja Batinac
AuthorIta Hadžisejdić
AuthorGordana Brumini
AuthorAlen Ružić
AuthorBožidar Vojniković
AuthorGordana Zamolo
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Dermatovenerology)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of General Pathology and Pathological Anatomy)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Dermatovenerology
Abstract (english)
To gain insight into the role and association of cell cycle and apoptosis regulatory proteins and telomerase activity in the course of progression of melanocitic lesions we have examined immunohistochemicaly, expression and the distribution of p53, bcl-2, Ki-67 and telomerase in 25 samples of common and dysplastic nevi, and 45 samples of primary invasive melanomas. Protein p53 expression was significantly increased in dysplastic as compared with common nevi and melanomas (p<0.001). Bcl-2 protein expression was significantly increased in melanomas as compared with common aquired and dysplastic nevi (p=0.001). Nevi and melanomas exhibited clear-cut differences in terms of Ki-67 expression. Telomerase expression was significantly increased in melanomas as compared with common acquired (p=0.014) and dysplastic nevi (p<0.001). Enhanced telomerase activity in association with increased bcl-2 expression in the course of melanoma progression could contribute to development and progression of melanoma.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCollegium antropologicum
Numberingvol. 31 - Supplement 1, no. 1, pp. 17-22
p-ISSN0350-6134
URN:NBNurn:nbn:hr:184:263269
Publication2007-01-16
Document URLhttp://hrcak.srce.hr/27415
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2017-09-17 18:47:34