prikaz prve stranice dokumenta Cell Apoptosis as Assessed by M30 Expression in Keratoacanthoma and Squamous Cell Carcinoma
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Scientific paper - Original scientific paper
Cell Apoptosis as Assessed by M30 Expression in Keratoacanthoma and Squamous Cell Carcinoma
Collegium antropologicum, 32 (2008), 2; 499-504. urn:nbn:hr:184:809787
Batinac, Tanja; Zamolo, Gordana; Brumini, Gordana; Biljan, Darko; Petranović, Duška; Trošelj-Vukić, Biserka

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Batinac, T., Zamolo, G., Brumini, G., Biljan, D., Petranović, D. & Trošelj Vukić, B. (2008). Cell Apoptosis as Assessed by M30 Expression in Keratoacanthoma and Squamous Cell Carcinoma. Collegium antropologicum, 32. (2), 499-504. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:809787

Batinac, Tanja, et al. "Cell Apoptosis as Assessed by M30 Expression in Keratoacanthoma and Squamous Cell Carcinoma." Collegium antropologicum, vol. 32, no. 2, 2008, pp. 499-504. https://urn.nsk.hr/urn:nbn:hr:184:809787

Batinac, Tanja, Gordana Zamolo, Gordana Brumini, Darko Biljan, Duška Petranović and Biserka Trošelj Vukić. "Cell Apoptosis as Assessed by M30 Expression in Keratoacanthoma and Squamous Cell Carcinoma." Collegium antropologicum 32, no. 2 (2008): 499-504. https://urn.nsk.hr/urn:nbn:hr:184:809787

Batinac, T., et al. (2008) 'Cell Apoptosis as Assessed by M30 Expression in Keratoacanthoma and Squamous Cell Carcinoma', Collegium antropologicum, 32(2), pp. 499-504. Available at: https://urn.nsk.hr/urn:nbn:hr:184:809787 (Accessed 26 December 2024)

Batinac T, Zamolo G, Brumini G, Biljan D, Petranović D, Trošelj Vukić B. Cell Apoptosis as Assessed by M30 Expression in Keratoacanthoma and Squamous Cell Carcinoma. Collegium antropologicum [Internet]. 2008 July 07 [cited 2024 December 26];32(2):499-504. Available at: https://urn.nsk.hr/urn:nbn:hr:184:809787

T. Batinac, G. Zamolo, G. Brumini, D. Biljan, D. Petranović and B. Trošelj Vukić, "Cell Apoptosis as Assessed by M30 Expression in Keratoacanthoma and Squamous Cell Carcinoma", Collegium antropologicum, vol. 32, no. 2, pp. 499-504, July 2008. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:809787. [Accessed: 26 December 2024]

Metadata
Title (english)Cell Apoptosis as Assessed by M30 Expression in Keratoacanthoma and Squamous Cell Carcinoma
AuthorTanja Batinac
AuthorGordana Zamolo
AuthorGordana Brumini
AuthorDarko Biljan
AuthorDuška Petranović
AuthorBiserka Trošelj-Vukić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Dermatovenerology)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of General Pathology and Pathological Anatomy)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Dermatovenerology
Abstract (english)
Involution displayed by keratoacanthoma (KA) represents an important difference between KA and squamous cell carcinoma (SCC). It has been suggested that apoptosis plays a part in process of involution of KA. Altogether 150 specimens were included in this study, 30 cases of each; normal skin (NS), proliferative (pKA) and regressing keratoacanthoma (rKA), well differentiated (wdSCC) and poorly differentiated (pdSCC) squamous cell carcinoma. All samples were examined immunohistochemicaly for expression of M30 protein. A significantly lower number of M30 positive cells has been detected in NS as compared to skin tumors examined (p<0.001), except for rKA (p=0.057). The highest percentage of M30 positive cells was detected in pdSCC (p<0.001) as compared with all other examined groups. Keratinocytes of normal and changed epidermis expressing higher levels of M30 protein were predominately found in sun-exposed areas (c 2=14.93; p=0.060). There was an increasing trend of M30 protein expression with increasing age of the patient in NS and skin tumors examined. Majority of skin tumors with higher percentage of M30 positive cells tended to display higher Ki-67 expression. M30 expression was highly correlated with bak (r=0.811; p=0.048) and granzyme B expression in rKA (r=0.733; p=0.015). Cell apoptosis as assessed by M30 expression is, generally, increased in examined skin tumors and related to cell proliferation. Cell apoptosis mediated by bak and granzyme B expression could contribute to KA regression.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review
Publication versionPublished version
Journal titleCollegium antropologicum
Numberingvol. 32, no. 2, pp. 499-504
p-ISSN0350-6134
URN:NBNurn:nbn:hr:184:809787
Publication2008-07-07
Document URLhttp://hrcak.srce.hr/27217
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2017-09-17 19:08:32