Title DIJAGNOSTIČKI ASPEKTI CISTIČNE FIBROZE
Title (english) DIAGNOSTIC ASPECTS OF CYSTIC FIBROSIS
Author Martina Vidović
Mentor Srđan Banac (mentor)
Committee member Goran Palčevski (predsjednik povjerenstva)
Committee member Srećko Severinski (član povjerenstva)
Committee member Ljiljana Bulat-Kardum (član povjerenstva)
Granter University of Rijeka Faculty of Medicine (Department of Pediatrics) Rijeka
Defense date and country 2017-07-14, Croatia
Scientific / art field, discipline and subdiscipline BIOMEDICINE AND HEALTHCARE Clinical Medical Sciences Pediatrics
Abstract Ciljevi rada: Analizirati i utvrditi dijagnostičke aspekte cistične fibroze (CF), uključujući i kliničke manifestacije ispitanika na Klinici za pedijatriju, Kliničkog bolničkog centra (KBC) Rijeka. Uz demografske podatke oboljelih, dob i spol, utvrditi i prosječnu dob postavljanja dijagnoze CF. Prikazati najčešće uzročnike infekcija dišnog sustava s obzirom na dob bolesnika te na temelju vrijednosti spirometrije utvrditi godišnji pad forsiranog ekspiratornog volumena u prvoj sekundi (FEV1). Materijali i postupci: Ovim istraživanjem obuhvaćeno je 14 oboljelih od CF koji su dijagnostički obrađivani te liječeni, u razdoblju od srpnja 2010. do travnja 2017., na Klinici za pedijatriju, KBC-a Rijeka. Rezultati: Prosječna dob postavljanja dijagnoze CF iznosila je 10, 5 mjeseci. Kod najvećeg broja oboljelih dijagnostička obrada započela je zbog nenapredovanja na težini, a samo kod jednog bolesnika zbog respiratornih simptoma. Utvrđeno je da je najčešća mutacija ΔF508. Kod šestero oboljelih dokazana je senzitizacija na inhalatorne alergene, od kojih dvoje pokazuje i senzitizaciju na plijesan Aspergillus fumigatus. Kod jednog bolesnika prisutna je ABPA. Najčešći izolat iz gornjeg i donjeg respiratornog sustava, do otprilike 16. godine, bio je Staphylococcus aureus, a zatim glavni kolonizator dišnih putova postaje Pseudomonas aeruginosa. Prosječni godišnji pad plućne funkcije iznosio je 1%. Zaključak: Dijagnostički aspekti CF temelje se na dijagnostičkom konsenzusu po kojem se postavlja sumnja, a zatim i dijagnoza. Rano prepoznavanje bolesti od strane specijalista pedijatrije te uporno i dosljedno provođenje terapijskih mjera od strane oboljelog, rezultira duljim i kvalitetnijim životom.
Abstract (english) Research goals: To analyze and determine diagnostic aspects of cystic fibrosis (CF), including clinical manifestations of subjects at the Pediatric Clinic, Clinical Hospital Center Rijeka. In addition to the demographic data of the patients, age and gender, determine the average age of diagnosis of CF. To show the most common respiratory tract infections depending on the age of the patient and to determine the annual fall in the forced expiratory volume in the first second (FEV1) based on the spirometry value. Research subjects: This study included 14 CF patients who have been diagnosed and treated in the period from July 2010 to April 2017 at the Pediatric Clinic of KBC Rijeka. Results: The average age of diagnosis of CF was 10, 5 months. In the largest number of diseased, diagnostic treatments started because of a weight loss, and only in one patient because of the respiratory symptoms. It was found that the most common mutation is ΔF508. Six patients were diagnosed with sensitization to inhaled allergens, and the two of them also showed a sensitization to the mildew Aspergillus fumigatus. ABPA was present in one patient. The most common isolate from the upper and lower respiratory system, up to approximately 16 years, was Staphylococcus aureus, and then the major airway colonizer became Pseudomonas aeruginosa. The average annual drop in pulmonary function was 1%. Conclusion: Diagnostic aspects of CF are based on a diagnostic consensus which may suspect the disease and then lead to the diagnosis. Early recognition of the disease by the pediatric specialist, and persistent and consistent implementation of therapeutic measures by the patient, results in a longer and better life.
Keywords
cistična fibroza
dijagnoza
infekcije
funkcija pluća
Keywords (english)
cystic fibrosis
diagnosis
infection
lung function
Language croatian
URN:NBN urn:nbn:hr:184:045627
Study programme Title: Medicine Study programme type: university Study level: integrated undergraduate and graduate Academic / professional title: doktor/doktorica medicine (doktor/doktorica medicine)
Type of resource Text
File origin Born digital
Access conditions Access restricted to students and staff of home institution
Terms of use
Created on 2017-11-21 10:42:55