prikaz prve stranice dokumenta Expression of metallothioneins in placental and fetal tissues in undisturbed and PGM-Zn treated syngeneic pregnancy
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Scientific paper - Original scientific paper
Expression of metallothioneins in placental and fetal tissues in undisturbed and PGM-Zn treated syngeneic pregnancy
American Journal of BioScience , Special Issue: Oxidants-Antioxidants, The Biological Balance., 3 (2015), 2-2; 1-7. https://doi.org/10.11648/j.ajbio.s.2015030202.12
Jakovac, Hrvoje; Grebić, Damir; Mrakovčić-Šutić, Ines; Rukavina, Daniel; Radošević-Stašić, Biserka

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Jakovac, H., Grebić, D., Mrakovčić Šutić, I., Rukavina, D. & Radošević Stašić, B. (2015). Expression of metallothioneins in placental and fetal tissues in undisturbed and PGM-Zn treated syngeneic pregnancy. American Journal of BioScience , Special Issue: Oxidants-Antioxidants, The Biological Balance., 3. (2-2), 1-7. doi: 10.11648/j.ajbio.s.2015030202.12

Jakovac, Hrvoje, et al. "Expression of metallothioneins in placental and fetal tissues in undisturbed and PGM-Zn treated syngeneic pregnancy." American Journal of BioScience , Special Issue: Oxidants-Antioxidants, The Biological Balance., vol. 3, no. 2-2, 2015, pp. 1-7. https://doi.org/10.11648/j.ajbio.s.2015030202.12

Jakovac, Hrvoje, Damir Grebić, Ines Mrakovčić Šutić, Daniel Rukavina and Biserka Radošević Stašić. "Expression of metallothioneins in placental and fetal tissues in undisturbed and PGM-Zn treated syngeneic pregnancy." American Journal of BioScience , Special Issue: Oxidants-Antioxidants, The Biological Balance. 3, no. 2-2 (2015): 1-7. https://doi.org/10.11648/j.ajbio.s.2015030202.12

Jakovac, H., et al. (2015) 'Expression of metallothioneins in placental and fetal tissues in undisturbed and PGM-Zn treated syngeneic pregnancy', American Journal of BioScience , Special Issue: Oxidants-Antioxidants, The Biological Balance., 3(2-2), pp. 1-7. doi: 10.11648/j.ajbio.s.2015030202.12

Jakovac H, Grebić D, Mrakovčić Šutić I, Rukavina D, Radošević Stašić B. Expression of metallothioneins in placental and fetal tissues in undisturbed and PGM-Zn treated syngeneic pregnancy. American Journal of BioScience , Special Issue: Oxidants-Antioxidants, The Biological Balance. [Internet]. 2015 [cited 2024 November 30];3(2-2):1-7. doi: 10.11648/j.ajbio.s.2015030202.12

H. Jakovac, D. Grebić, I. Mrakovčić Šutić, D. Rukavina and B. Radošević Stašić, "Expression of metallothioneins in placental and fetal tissues in undisturbed and PGM-Zn treated syngeneic pregnancy", American Journal of BioScience , Special Issue: Oxidants-Antioxidants, The Biological Balance., vol. 3, no. 2-2, pp. 1-7, 2015. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:865526. [Accessed: 30 November 2024]

Metadata
Title (english)Expression of metallothioneins in placental and fetal tissues in undisturbed and PGM-Zn treated syngeneic pregnancy
AuthorHrvoje Jakovac
AuthorDamir Grebić
AuthorInes Mrakovčić-Šutić
AuthorDaniel Rukavina
AuthorBiserka Radošević-Stašić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Physiology, Immunology and Pathophxsiology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Metallothioneins (MTs) are cysteine-rich proteins, which have been implicated in regulation of physiological processes, such as cell growth, repair, differentiation, apoptosis and immunoregulation, as well as in the protection against heavy metals, oxidant damages, inflammation and other stressful conditions. To investigate their roles in physiological and detoxification processes at the maternal-fetal interface and in fetal organogenesis we examined the tissue expression of MT I/II isoforms in undisturbed syngeneic pregnancy and after the treatment with peptidoglycan monomer linked with zinc (PGM-Zn). The data showed that in undisturbed pregnancy the MTs were highly expressed at junctional zone of placenta, on endovascular trophoblast giant cells, glycogen cells and spongiotrophoblast cells, as well as on villous trophoblast cells. In the fetus they were found predominantly in the liver and in epithelial tissues, such as intestine, pancreas and kidney. Treatment with PGM-Zn markedly enhanced the intensity of MT staining both at the maternal-fetal interface and in fetal organs. The data imply that MTs are involved in the protection of trophoblast cells against the pregnancy-induced deregulation of redox and neuro-immuno-endocrine homeostasis, in transport and storage of essential metals required for fetal organogenesis, as well as in the protection of fetus against bacterial toxins.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleAmerican Journal of BioScience , Special Issue: Oxidants-Antioxidants, The Biological Balance.
Numberingvol. 3, no. 2-2, pp. 1-7
p-ISSN2330-0159
DOIhttps://doi.org/10.11648/j.ajbio.s.2015030202.12
URN:NBNurn:nbn:hr:184:865526
Publication2015
ProjectNumber: 13.06.1.1.16
Title (croatian): Citoprotektivna i imunoregulacijska svojstva glikoproteina 96 i metalotioneina
Leader: Radošević-Stašić, Biserka
Jurisdiction: Croatia
Document URLhttp://www.sciencepublishinggroup.com/j/ajbio
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NoDerivatives 4.0 International (CC BY-ND 4.0) icon
Created on2017-11-23 20:24:15