prikaz prve stranice dokumenta Systemic Virus Infections Differentially Modulate Cell Cycle State and Functionality of Long-Term Hematopoietic Stem Cells In Vivo
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Scientific paper - Original scientific paper
Systemic Virus Infections Differentially Modulate Cell Cycle State and Functionality of Long-Term Hematopoietic Stem Cells In Vivo
Cell Reports, 19 (2017), 11; 2345-2356. https://doi.org/10.1016/j.celrep.2017.05.063
Hirche, Christoph; ...; ...; Brizić, Ilija; ...; Jonjić, Stipan; ...

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Hirche, C., Brizić, I. & Jonjić, S. (2017). Systemic Virus Infections Differentially Modulate Cell Cycle State and Functionality of Long-Term Hematopoietic Stem Cells In Vivo. Cell Reports, 19. (11), 2345-2356. doi: 10.1016/j.celrep.2017.05.063

Hirche, Christoph, et al. "Systemic Virus Infections Differentially Modulate Cell Cycle State and Functionality of Long-Term Hematopoietic Stem Cells In Vivo." Cell Reports, vol. 19, no. 11, 2017, pp. 2345-2356. https://doi.org/10.1016/j.celrep.2017.05.063

Hirche, Christoph, Ilija Brizić and Stipan Jonjić. "Systemic Virus Infections Differentially Modulate Cell Cycle State and Functionality of Long-Term Hematopoietic Stem Cells In Vivo." Cell Reports 19, no. 11 (2017): 2345-2356. https://doi.org/10.1016/j.celrep.2017.05.063

Hirche, C., Brizić, I. and Jonjić, S. (2017) 'Systemic Virus Infections Differentially Modulate Cell Cycle State and Functionality of Long-Term Hematopoietic Stem Cells In Vivo', Cell Reports, 19(11), pp. 2345-2356. doi: 10.1016/j.celrep.2017.05.063

Hirche C, Brizić I, Jonjić S. Systemic Virus Infections Differentially Modulate Cell Cycle State and Functionality of Long-Term Hematopoietic Stem Cells In Vivo. Cell Reports [Internet]. 2017 June 13 [cited 2024 May 14];19(11):2345-2356. doi: 10.1016/j.celrep.2017.05.063

C. Hirche, I. Brizić and S. Jonjić, "Systemic Virus Infections Differentially Modulate Cell Cycle State and Functionality of Long-Term Hematopoietic Stem Cells In Vivo", Cell Reports, vol. 19, no. 11, pp. 2345-2356, June 2017. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:799458. [Accessed: 14 May 2024]

Metadata
Title (english)Systemic Virus Infections Differentially Modulate Cell Cycle State and Functionality of Long-Term Hematopoietic Stem Cells In Vivo
AuthorChristoph Hirche
Author
...
Author
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AuthorIlija Brizić
Author
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AuthorStipan Jonjić
Author
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Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Quiescent long-term hematopoietic stem cells (LT-HSCs) are efficiently activated by type I interferon (IFN-I). However, this effect remains poorly investigated in the context of IFN-I-inducing virus infections. Here we report that both vesicular stomatitis virus (VSV) and murine cytomegalovirus (MCMV) infection induce LT-HSC activation that substantially differs from the effects triggered upon injection of synthetic IFN-I-inducing agents. In both infections, inflammatory responses had to exceed local thresholds within the bone marrow to confer LT-HSC cell cycle entry, and IFN-I receptor triggering was not critical for this activation. After resolution of acute MCMV infection, LT-HSCs returned to phenotypic quiescence. However, non-acute MCMV infection induced a sustained inflammatory milieu within the bone marrow that was associated with long-lasting impairment of LT-HSC function. In conclusion, our results show that systemic virus infections fundamentally affect LT-HSCs and that also non-acute inflammatory stimuli in bone marrow donors can affect the reconstitution potential of bone marrow transplants
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleCell Reports
Numberingvol. 19, no. 11, pp. 2345-2356
p-ISSN2211-1247
DOIhttps://doi.org/10.1016/j.celrep.2017.05.063
URN:NBNurn:nbn:hr:184:799458
Publication2017-06-13
ProjectNumber: 062-0621261-1263
Title (croatian): Molekularni mehanizmi citomegalovirusnog izmicanja imunološkom nadzoru
Leader: Stipan Jonjić
Jurisdiction: Croatia
Funding stream: ZP
Document URLhttps://ac.els-cdn.com/S2211124717307209/1-s2.0-S2211124717307209-main.pdf?_tid=61ef015c-eae6-11e7-a977-00000aab0f6c&acdnat=1514366266_86ea78e0ed4a3c52eadaa60f50d7c382
Type of resourceText
Access conditionsOpen access
Terms of useLicence In copyright icon
Created on2017-12-27 09:15:01