prikaz prve stranice dokumenta Inflammatory monocytes and NK cells play a crucial role in DNAM-1-dependent control of cytomegalovirus infection
  Download
PDF 2.47 MB
Scientific paper - Original scientific paper
Inflammatory monocytes and NK cells play a crucial role in DNAM-1-dependent control of cytomegalovirus infection
JOURNAL OF EXPERIMENTAL MEDICINE, 213 (2016), 9; 1835-1850. https://doi.org/10.1084/jem.20151899
Lenac Roviš, Tihana; Kučan Brlić, Paola; Kaynan, Noa; Juranić Lisnić, Vanda; Brizić, Ilija; Jordan, Stefan; Tomić, Adriana; Kveštak, Daria; Babić, Marina; Tsukerman, Pinchas; Colonna, Marco; Koszinowski, Ulrich; Messerle, Martin; Mandelboim, Ofer; Krmpotić, Astrid; Jonjić, Stipan More authors...

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

Cite this document

Lenac Roviš, T., Kučan Brlić, P., Kaynan, N., Juranić Lisnić, V., Brizić, I., Jordan, S. ... Jonjić, S. (2016). Inflammatory monocytes and NK cells play a crucial role in DNAM-1-dependent control of cytomegalovirus infection. JOURNAL OF EXPERIMENTAL MEDICINE, 213. (9), 1835-1850. doi: 10.1084/jem.20151899

Lenac Roviš, Tihana, et al. "Inflammatory monocytes and NK cells play a crucial role in DNAM-1-dependent control of cytomegalovirus infection." JOURNAL OF EXPERIMENTAL MEDICINE, vol. 213, no. 9, 2016, pp. 1835-1850. https://doi.org/10.1084/jem.20151899

Lenac Roviš, Tihana, Paola Kučan Brlić, Noa Kaynan, Vanda Juranić Lisnić, Ilija Brizić, Stefan Jordan, Adriana Tomić, et al. "Inflammatory monocytes and NK cells play a crucial role in DNAM-1-dependent control of cytomegalovirus infection." JOURNAL OF EXPERIMENTAL MEDICINE 213, no. 9 (2016): 1835-1850. https://doi.org/10.1084/jem.20151899

Lenac Roviš, T., et al. (2016) 'Inflammatory monocytes and NK cells play a crucial role in DNAM-1-dependent control of cytomegalovirus infection', JOURNAL OF EXPERIMENTAL MEDICINE, 213(9), pp. 1835-1850. doi: 10.1084/jem.20151899

Lenac Roviš T, Kučan Brlić P, Kaynan N, Juranić Lisnić V, Brizić I, Jordan S, and sur.. Inflammatory monocytes and NK cells play a crucial role in DNAM-1-dependent control of cytomegalovirus infection. JOURNAL OF EXPERIMENTAL MEDICINE [Internet]. 2016 [cited 2024 December 24];213(9):1835-1850. doi: 10.1084/jem.20151899

T. Lenac Roviš, et al., "Inflammatory monocytes and NK cells play a crucial role in DNAM-1-dependent control of cytomegalovirus infection", JOURNAL OF EXPERIMENTAL MEDICINE, vol. 213, no. 9, pp. 1835-1850, 2016. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:074639. [Accessed: 24 December 2024]

Metadata
Title (english)Inflammatory monocytes and NK cells play a crucial role in DNAM-1-dependent control of cytomegalovirus infection
AuthorTihana Lenac Roviš
AuthorPaola Kučan Brlić
AuthorNoa Kaynan
AuthorVanda Juranić Lisnić
AuthorIlija Brizić
AuthorStefan Jordan
AuthorAdriana Tomić
AuthorDaria Kveštak
AuthorMarina Babić
AuthorPinchas Tsukerman
AuthorMarco Colonna
AuthorUlrich Koszinowski
AuthorMartin Messerle
AuthorOfer Mandelboim
AuthorAstrid Krmpotić
AuthorStipan Jonjić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
The poliovirus receptor (PVR) is a ubiquitously expressed glycoprotein involved in cellular adhesion and immune response. It engages the activating receptor DNAX accessory molecule (DNAM)-1, the inhibitory receptor TIG IT, and the CD96 receptor with both activating and inhibitory functions. Human cytomegalovirus (HCMV) down-regulates PVR expression, but the significance of this viral function in vivo remains unknown. Here, we demonstrate that mouse CMV (MCMV) also down-regulates the surface PVR. The m20.1 protein of MCMV retains PVR in the endoplasmic reticulum and promotes its degradation. A MCMV mutant lacking the PVR inhibitor was attenuated in normal mice but not in mice lacking DNAM-1. This attenuation was partially reversed by NK cell depletion, whereas the simultaneous depletion of mononuclear phagocytes abolished the virus control. This effect was associated with the increased expression of DNAM-1, whereas TIG IT and CD96 were absent on these cells. An increased level of proinflammatory cytokines in sera of mice infected with the virus lacking the m20.1 and an increased production of iNOS by inflammatory monocytes was observed. Blocking of CCL2 or the inhibition of iNOS significantly increased titer of the virus lacking m20.1. In this study, we have demonstrated that inflammatory monocytes, together with NK cells, are essential in the early control of CMV through the DNAM-1–PVR pathway
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleJOURNAL OF EXPERIMENTAL MEDICINE
Numberingvol. 213, no. 9, pp. 1835-1850
e-ISSN1540-9538
DOIhttps://doi.org/10.1084/jem.20151899
URN:NBNurn:nbn:hr:184:074639
Publication2016
ProjectNumber: UIP-2013-11-1533
Title (croatian): Molekularni mehanizmi imunološkog djelovanja PVR(CD155) u virusnoj i tumorskoj patogenezi
Acronym: PVRreg
Leader: Tihana Lenac Roviš
Jurisdiction: Croatia
Funding stream: UIP
ProjectNumber: 322693
Title (english): Strengthening adaptive immunity via innate immunity: enhancing the CD8 T cell response by using the NKG2D ligand expressed in a herpesvirus vector
Acronym: STADVINN
Jurisdiction: eu
Funding stream: FP7
Document URLhttp://jem.rupress.org/content/jem/213/9/1835.full.pdf
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivs 3.0 Unported (CC BY-NC-ND 3.0) icon
Created on2017-12-27 10:04:28