prikaz prve stranice dokumenta Methemoglobinemia as biomarker and precursor of brain capillary oxidative damage link to ferric iron accumulation and originator of neurodegenerative disease
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Scientific paper - Original scientific paper
Methemoglobinemia as biomarker and precursor of brain capillary oxidative damage link to ferric iron accumulation and originator of neurodegenerative disease
Journal of Systems and Integrative Neuroscience, 3 (2017), 5; 1-5. https://doi.org/10.15761/JSIN.1000180
Mohorović, Lucijan; Lavezzi, Anna M.; Jonjić, Nives; Štifter, Sanja; Perry, George; Malatestinić, Đulija; Mićović, Vladimir; Materljan, Eris; Haller, Herman; Petrović, Oleg

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Mohorović, L., Lavezzi, A. M., Jonjić, N., Štifter, S., Perry, G., Malatestinić, Đ. ... Petrović, O. (2017). Methemoglobinemia as biomarker and precursor of brain capillary oxidative damage link to ferric iron accumulation and originator of neurodegenerative disease. Journal of Systems and Integrative Neuroscience, 3. (5), 1-5. doi: 10.15761/JSIN.1000180

Mohorović, Lucijan, et al. "Methemoglobinemia as biomarker and precursor of brain capillary oxidative damage link to ferric iron accumulation and originator of neurodegenerative disease." Journal of Systems and Integrative Neuroscience, vol. 3, no. 5, 2017, pp. 1-5. https://doi.org/10.15761/JSIN.1000180

Mohorović, Lucijan, Anna M. Lavezzi, Nives Jonjić, Sanja Štifter, George Perry, Đulija Malatestinić, Vladimir Mićović, Eris Materljan, Herman Haller and Oleg Petrović. "Methemoglobinemia as biomarker and precursor of brain capillary oxidative damage link to ferric iron accumulation and originator of neurodegenerative disease." Journal of Systems and Integrative Neuroscience 3, no. 5 (2017): 1-5. https://doi.org/10.15761/JSIN.1000180

Mohorović, L., et al. (2017) 'Methemoglobinemia as biomarker and precursor of brain capillary oxidative damage link to ferric iron accumulation and originator of neurodegenerative disease', Journal of Systems and Integrative Neuroscience, 3(5), pp. 1-5. doi: 10.15761/JSIN.1000180

Mohorović L, Lavezzi AM, Jonjić N, Štifter S, Perry G, Malatestinić Đ, and sur.. Methemoglobinemia as biomarker and precursor of brain capillary oxidative damage link to ferric iron accumulation and originator of neurodegenerative disease. Journal of Systems and Integrative Neuroscience [Internet]. 2017 [cited 2024 December 25];3(5):1-5. doi: 10.15761/JSIN.1000180

L. Mohorović, et al., "Methemoglobinemia as biomarker and precursor of brain capillary oxidative damage link to ferric iron accumulation and originator of neurodegenerative disease", Journal of Systems and Integrative Neuroscience, vol. 3, no. 5, pp. 1-5, 2017. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:552203. [Accessed: 25 December 2024]

Metadata
Title (english)Methemoglobinemia as biomarker and precursor of brain capillary oxidative damage link to ferric iron accumulation and originator of neurodegenerative disease
AuthorLucijan Mohorović
AuthorAnna M. Lavezzi
AuthorNives Jonjić
AuthorSanja Štifter
MBZ: 247706
AuthorGeorge Perry
AuthorĐulija Malatestinić
AuthorVladimir Mićović
AuthorEris Materljan
AuthorHerman Haller
MBZ: 146311
AuthorOleg Petrović
MBZ: 156540
Author's institutionUniversity of Rijeka
Faculty of Medicine
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Abstract (english)
Our main aim is to make a contribution to the establishment of sources of oxidants as the key factors in understanding the role that oxidants and oxidative stress play in the pathogenesis of neurodegeneration, i.e. in the progression of Alzheimer’s disease (AD). Our original observation pointed out the main difference between the hemoglobin and methemoglobin degradation, did from the heme oxygenation when a hemoglobin results in ferrous (Fe2+) iron, but methemoglobin catabolism produces ferric (Fe3+) iron. The methemoglobin plays a role of the carrier, the donor of cytotoxic and redox- active ferric (Fe3+) iron, and it also acts as the originator of neurodegenerative diseases. The abundant and permanent source of redox- active ferric (Fe3+) iron which, without Ferrous-Ferric inversions, has “in situ” direct impact on endothelial small vessels in the brain accumulates and increases the rate of capillary endothelial cell apoptosis and possibly crosses into brain parenchyma to the astrocytes, glia, neurons, and other neuronal cells. Our understanding of the transport and neuronal accumulation of ferric (Fe3+) iron points to how microvessels are organized into a well-structured neurovascular unit with harmful consequences to the brain. Our previously conducted research found that the neonatal jaundice incidence (p=0.034), heart murmur at a later age (p=0.011) and mild disorders in children and adults such as dyslalia and learning/memory impairments (p=0.002) were significantly higher than in children and adults of control mothers without pregnancy methemoglobinemia. The consequence are performed as initial brain iron harmful effects from the mother-fetal pregnancy methemoglobinemia complication, and according to our hypothesis in humans could be followed with the neuronal death, the disease aging process, and leading finally to the severe disorders as AD, PD and other neurodegenerative diseases.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleJournal of Systems and Integrative Neuroscience
Numberingvol. 3, no. 5, pp. 1-5
e-ISSN2059-9781
DOIhttps://doi.org/10.15761/JSIN.1000180
URN:NBNurn:nbn:hr:184:552203
Publication2017
Document URLhttp://bib.irb.hr/916579
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) icon
Created on2018-01-08 18:44:28