prikaz prve stranice dokumenta Intrinsic Contribution of Perforin to NK-Cell Homeostasis during Mouse Cytomegalovirus Infection
  Download
PDF 4.33 MB
Scientific paper - Original scientific paper
Intrinsic Contribution of Perforin to NK-Cell Homeostasis during Mouse Cytomegalovirus Infection
Frontiers in Immunology, 7 (2016); 133. https://doi.org/10.3389/fimmu.2016.00133
Arapović, Maja; Brizić, Ilija; Popović, Branka; Jurković, Slaven; Jordan, Stefan; Krmpotić, Astrid; Arapović, Jurica; Jonjić, Stipan

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

Cite this document

Arapović, M., Brizić, I., Popović, B., Jurković, S., Jordan, S., Krmpotić, A. ... Jonjić, S. (2016). Intrinsic Contribution of Perforin to NK-Cell Homeostasis during Mouse Cytomegalovirus Infection. Frontiers in Immunology, 7.. doi: 10.3389/fimmu.2016.00133

Arapović, Maja, et al. "Intrinsic Contribution of Perforin to NK-Cell Homeostasis during Mouse Cytomegalovirus Infection." Frontiers in Immunology, vol. 7, 2016. https://doi.org/10.3389/fimmu.2016.00133

Arapović, Maja, Ilija Brizić, Branka Popović, Slaven Jurković, Stefan Jordan, Astrid Krmpotić, Jurica Arapović and Stipan Jonjić. "Intrinsic Contribution of Perforin to NK-Cell Homeostasis during Mouse Cytomegalovirus Infection." Frontiers in Immunology 7 (2016). https://doi.org/10.3389/fimmu.2016.00133

Arapović, M., et al. (2016) 'Intrinsic Contribution of Perforin to NK-Cell Homeostasis during Mouse Cytomegalovirus Infection', Frontiers in Immunology, 7. doi: 10.3389/fimmu.2016.00133

Arapović M, Brizić I, Popović B, Jurković S, Jordan S, Krmpotić A, and sur.. Intrinsic Contribution of Perforin to NK-Cell Homeostasis during Mouse Cytomegalovirus Infection. Frontiers in Immunology [Internet]. 2016 [cited 2024 November 23];7. doi: 10.3389/fimmu.2016.00133

M. Arapović, et al., "Intrinsic Contribution of Perforin to NK-Cell Homeostasis during Mouse Cytomegalovirus Infection", Frontiers in Immunology, vol. 7, 2016. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:039075. [Accessed: 23 November 2024]

Metadata
Title (english)Intrinsic Contribution of Perforin to NK-Cell Homeostasis during Mouse Cytomegalovirus Infection
AuthorMaja Arapović
AuthorIlija Brizić
AuthorBranka Popović
AuthorSlaven Jurković
AuthorStefan Jordan
AuthorAstrid Krmpotić
AuthorJurica Arapović
AuthorStipan Jonjić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
In addition to their role as effector cells in virus control, natural killer (NK) cells have an immunoregulatory function in shaping the antiviral T-cell response. This function is further pronounced in perforin-deficient mice that show the enhanced NK-cell proliferation and cytokine secretion upon mouse cytomegalovirus (MCMV) infection. Here, we confirmed that stronger activation and maturation of NK cells in perforin-deficient mice correlates with higher MCMV load. To further characterize the immunoregulatory potential of perfo- rin, we compared the response of NK cells that express or do not express perforin using bone-marrow chimeras. Our results demonstrated that the enhanced proliferation and maturation of NK cells in MCMV-infected bone-marrow chimeras is an intrinsic property of perforin-deficient NK cells. Thus, in addition to confirming that NK-cell proliferation is virus load dependent, our data extend this notion demonstrating that perforin plays an intrinsic role as a feedback mechanism in the regulation of NK-cell proliferation during viral infections
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleFrontiers in Immunology
Numberingvol. 7, 133
e-ISSN1664-3224
DOIhttps://doi.org/10.3389/fimmu.2016.00133
URN:NBNurn:nbn:hr:184:039075
Publication2016
ProjectNumber: IP-2013-11-7132
Title (croatian): Aktivacijski receptori NK-stanica specifični za virus i njihovo izbjegavanje od strane virusa
Acronym: ViSpeNKRec
Leader: Astrid Krmpotić
Jurisdiction: Croatia
Funding stream: IP
ProjectNumber: 322693
Title (english): Strengthening adaptive immunity via innate immunity: enhancing the CD8 T cell response by using the NKG2D ligand expressed in a herpesvirus vector
Acronym: STADVINN
Jurisdiction: eu
Funding stream: FP7
Document URLhttp://www.readcube.com/articles/10.3389/fimmu.2016.00133
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) icon
Created on2018-01-18 15:25:32