prikaz prve stranice dokumenta Ribosome biogenesis in cancer: new players and therapeutic avenues
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Scientific paper - Original scientific paper
Ribosome biogenesis in cancer: new players and therapeutic avenues
Nature Reviews Cancer, 18 (2018), 1; 51-63. https://doi.org/10.1038/nrc.2017.104
Pelletier, Joffrey; Thomas, George; Volarević, Siniša

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

Cite this document

Pelletier, J., Thomas, G. & Volarević, S. (2018). Ribosome biogenesis in cancer: new players and therapeutic avenues. Nature Reviews Cancer, 18. (1), 51-63. doi: 10.1038/nrc.2017.104

Pelletier, Joffrey, et al. "Ribosome biogenesis in cancer: new players and therapeutic avenues." Nature Reviews Cancer, vol. 18, no. 1, 2018, pp. 51-63. https://doi.org/10.1038/nrc.2017.104

Pelletier, Joffrey, George Thomas and Siniša Volarević. "Ribosome biogenesis in cancer: new players and therapeutic avenues." Nature Reviews Cancer 18, no. 1 (2018): 51-63. https://doi.org/10.1038/nrc.2017.104

Pelletier, J., Thomas, G. and Volarević, S. (2018) 'Ribosome biogenesis in cancer: new players and therapeutic avenues', Nature Reviews Cancer, 18(1), pp. 51-63. doi: 10.1038/nrc.2017.104

Pelletier J, Thomas G, Volarević S. Ribosome biogenesis in cancer: new players and therapeutic avenues. Nature Reviews Cancer [Internet]. 2018 January [cited 2024 November 30];18(1):51-63. doi: 10.1038/nrc.2017.104

J. Pelletier, G. Thomas and S. Volarević, "Ribosome biogenesis in cancer: new players and therapeutic avenues", Nature Reviews Cancer, vol. 18, no. 1, pp. 51-63, January 2018. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:981273. [Accessed: 30 November 2024]

Metadata
Title (english)Ribosome biogenesis in cancer: new players and therapeutic avenues
AuthorJoffrey Pelletier
AuthorGeorge Thomas
AuthorSiniša Volarević
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Molecular Medicine and Biotechnology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
The ribosome is a complex molecular machine composed of numerous distinct proteins and nucleic acids and is responsible for protein synthesis in every living cell. Ribosome biogenesis is one of the most multifaceted and energy- demanding processes in biology, involving a large number of assembly and maturation factors, the functions of which are orchestrated by multiple cellular inputs, including mitogenic signals and nutrient availability. Although causal associations between inherited mutations affecting ribosome biogenesis and elevated cancer risk have been established over the past decade, mechanistic data have emerged suggesting a broader role for dysregulated ribosome biogenesis in the development and progression of most spontaneous cancers. In this Opinion article, we highlight the most recent findings that provide new insights into the molecular basis of ribosome biogenesis in cancer and offer our perspective on how these observations present opportunities for the design of new targeted cancer treatments.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleNature Reviews Cancer
Numberingvol. 18, no. 1, pp. 51-63
p-ISSN1474-175X
DOIhttps://doi.org/10.1038/nrc.2017.104
URN:NBNurn:nbn:hr:184:981273
Publication2018-01
Document URLhttp://bib.irb.hr/914939
Type of resourceText
Access conditionsRestricted access
Terms of useLicence In copyright icon
Created on2018-01-22 18:02:37