| Abstract (croatian) | Cilj: Shizofreniju karakterizira visoka učestalost ovisnosti o pušenju, kao i visoka učestalost metaboličkog sindroma. Unatoč tome, malo se zna o učinku pušenja na komponente metaboličkog sindroma u toj bolesti. Cilj ovog rada bio je ispitati doprinosi li, i u kojoj mjeri, pojava ovisnosti o pušenju, koncentracijama lipida i glukoze u plazmi, te vrijednostima indeksa tjelesne mase (BMI), u skupini hrvatskih bolesnika sa shizofrenijom.
Ispitanici i metode: U istraživanju je sudjelovalo 263 kroničnih bolesnika (muškarci/žene: 139/124) s dijagnozom shizofrenije utvrđenom prema DSM-IV klasifikaciji (engl. Diagnostic and statistical manual for mental disorders – DSM-IV). U pušače su klasificirani ispitanici koji puše najmanje jednu cigaretu dnevno u periodu duljem od godine dana, a u nepušače oni koji su popušili manje od 100 cigareta tijekom života.
Rezultati: Unatoč visokoj stopi ovisnosti o pušenju (muškarci: 70,5%; žene: 60,5%), nije pronađena značajna razlika u koncentracijama lipida i glukoze u plazmi te vrijednostima BMI-a između muškaraca pušača i nepušača, a u žena su se samo koncentracije triglicerida razlikovale ovisno o pušačkom statusu. Pri tome su bolesnice koje puše imale nešto više vrijednosti triglicerida u usporedbi s bolesnicama nepušačima (1,6 ± 0,7 vs. 1,3 ± 0,5; F = 4,25, P = 0,042). Ipak, multipla regresijska analiza pokazala je da je samo dob značajni prediktor vrijednosti triglicerida u bolesnica (β = 0,41; promjena R2 = 0,171; P < 0,001), dok je učinak pušenja na koncentracije triglicerida, kao i na ostale ispitane metaboličke parametre, u bolesnika i bolesnica, ostao izvan granica statističke značajnosti (P > 0,05).
Zaključak: Na temelju naših rezultata, možemo zaključiti da pušenje ne utječe na koncentracije lipida i glukoze u plazmi te vrijednosti BMI-a niti u bolesnika, niti u bolesnica sa shizofrenijom. |
| Abstract (english) | Aim: Schizophrenia is associated with a high rate of nicotine dependence as well as with a high prevalence of metabolic syndrome. However, little is known about the influence of smoking on components of metabolic syndrome in this illness. In the current study we aim to investigate whether, and to what extent, smoking may contribute to plasma lipid and glucose concentrations and body mass index (BMI) values in Croatian patients with schizophrenia.
Patients and methods: Our study comprised 263 chronically ill patients (males/females: 139/124) who met criteria for schizophrenia, according to the Diagnostic and Statistical Manual of Mental Disorders (DSM-IV). Smokers were defined as individuals who smoked more than one cigarette each day for more than one year, and nonsmokers were defined as those who had smoked fewer than 100 cigarettes during their lifetime.
Results: Although an elevated smoking rate was detected (males: 70.5%; females: 60.5%), we did not observe significant differences in plasma lipid and glucose concentrations and BMI values between male smokers and nonsmokers; whereas, among females, we revealed variations only in triglyceride concentrations according to the smoking status. In particular, triglyceride concentrations were slightly higher among female smokers than among nonsmoking females (1.6 ± 0.7 vs. 1.3 ± 0.5; F = 4.25, P = 0.042). However, multiple regression analysis revealed that only age was a significant predictor of triglyceride values in females (β = 0.41, R2 change = 0.171, P < 0.001), whereas the influence of smoking on triglyceride values as well as on other investigated metabolic parameters was not statistically significant, neither among males, nor among females (P > 0.05).
Conclusion: According to our results, we may conclude that smoking does not influence plasma lipid and glucose concentrations and BMI values neither among male nor among female patients with schizophrenia. |
