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Scientific paper - Review paper
Nucleolus as an emerging hub in maintenance of genome stability and cancer pathogenesis
Oncogene, 37 (2018), 18; 2351-2366. https://doi.org/10.1038/s41388-017-0121-z
Lindström, Mikael S.; Jurada, Deana; Bursać, Slađana; Oršolic, Ines; Bartek, Jiri; Volarević, Siniša

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Lindström, M. S., Jurada, D., Bursać, S., Oršolic, I., Bartek, J. & Volarević, S. (2018). Nucleolus as an emerging hub in maintenance of genome stability and cancer pathogenesis. Oncogene, 37. (18), 2351-2366. doi: 10.1038/s41388-017-0121-z

Lindström, Mikael S., et al. "Nucleolus as an emerging hub in maintenance of genome stability and cancer pathogenesis." Oncogene, vol. 37, no. 18, 2018, pp. 2351-2366. https://doi.org/10.1038/s41388-017-0121-z

Lindström, Mikael S., Deana Jurada, Slađana Bursać, Ines Oršolic, Jiri Bartek and Siniša Volarević. "Nucleolus as an emerging hub in maintenance of genome stability and cancer pathogenesis." Oncogene 37, no. 18 (2018): 2351-2366. https://doi.org/10.1038/s41388-017-0121-z

Lindström, M. S., et al. (2018) 'Nucleolus as an emerging hub in maintenance of genome stability and cancer pathogenesis', Oncogene, 37(18), pp. 2351-2366. doi: 10.1038/s41388-017-0121-z

Lindström MS, Jurada D, Bursać S, Oršolic I, Bartek J, Volarević S. Nucleolus as an emerging hub in maintenance of genome stability and cancer pathogenesis. Oncogene [Internet]. 2018 February 12 [cited 2024 November 26];37(18):2351-2366. doi: 10.1038/s41388-017-0121-z

M. S. Lindström, D. Jurada, S. Bursać, I. Oršolic, J. Bartek and S. Volarević, "Nucleolus as an emerging hub in maintenance of genome stability and cancer pathogenesis", Oncogene, vol. 37, no. 18, pp. 2351-2366, February 2018. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:398492. [Accessed: 26 November 2024]

Metadata
Title (english)Nucleolus as an emerging hub in maintenance of genome stability and cancer pathogenesis
AuthorMikael S. Lindström
AuthorDeana Jurada
AuthorSlađana Bursać
AuthorInes Oršolic
AuthorJiri Bartek
AuthorSiniša Volarević
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Molecular Medicine and Biotechnology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
The nucleolus is the major site for synthesis of ribosomes, complex molecular machines that are responsible for protein synthesis. A wealth of research over the past 20 years has clearly indicated that both quantitative and qualitative alterations in ribosome biogenesis can drive the malignant phenotype via dysregulation of protein synthesis. However, numerous recent proteomic, genomic, and functional studies have implicated the nucleolus in the regulation of processes that are unrelated to ribosome biogenesis, including DNA-damage response, maintenance of genome stability and its spatial organization, epigenetic regulation, cell-cycle control, stress responses, senescence, global gene expression, as well as assembly or maturation of various ribonucleoprotein particles. In this review, the focus will be on features of rDNA genes, which make them highly vulnerable to DNA damage and intra- and interchromosomal recombination as well as built-in mechanisms that prevent and repair rDNA damage, and how dysregulation of this interplay affects genome-wide DNA stability, gene expression and the balance between euchromatin and heterochromatin. We will also present the most recent insights into how malfunction of these cellular processes may be a central driving force of human malignancies, and propose a promising new therapeutic approach for the treatment of cancer.
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleOncogene
Numberingvol. 37, no. 18, pp. 2351-2366
p-ISSN0950-9232
e-ISSN1476-5594
DOIhttps://doi.org/10.1038/s41388-017-0121-z
URN:NBNurn:nbn:hr:184:398492
Publication2018-02-12
ProjectNumber: IP-2016-06-2079
Title (croatian): Uloga heterozigotnosti gena za ribosomski protein S6 u zloćudnoj preoprazbi stanica
Acronym: ONCO-RIB
Leader: Siniša Volarević
Jurisdiction: Croatia
Funding stream: IP
Document URLhttp://www.nature.com/articles/s41388-017-0121-z
Type of resourceText
Access conditionsInstitutional access
Terms of useLicence In copyright icon
Created on2018-05-08 19:17:54