prikaz prve stranice dokumenta EGFR protein overexpression correlates with chromosome 7 polysomy and poor prognostic parameters in clear cell renal cell carcinoma
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Scientific paper - Original scientific paper
EGFR protein overexpression correlates with chromosome 7 polysomy and poor prognostic parameters in clear cell renal cell carcinoma
British Journal of Biomedical Science, 19 (2012), 40; 1-8. https://doi.org/10.1186/1423-0127-19-40
Đorđević, Gordana; Matušan-Ilijaš, Koviljka; Hadžisejdić, Ita; Maričić, Anton; Grahovac, Blaženka; Jonjić, Nives

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Đorđević, G., Matušan Ilijaš, K., Hadžisejdić, I., Maričić, A., Grahovac, B. & Jonjić, N. (2012). EGFR protein overexpression correlates with chromosome 7 polysomy and poor prognostic parameters in clear cell renal cell carcinoma. British Journal of Biomedical Science, 19. (40), 1-8. doi: 10.1186/1423-0127-19-40

Đorđević, Gordana, et al. "EGFR protein overexpression correlates with chromosome 7 polysomy and poor prognostic parameters in clear cell renal cell carcinoma." British Journal of Biomedical Science, vol. 19, no. 40, 2012, pp. 1-8. https://doi.org/10.1186/1423-0127-19-40

Đorđević, Gordana, Koviljka Matušan Ilijaš, Ita Hadžisejdić, Anton Maričić, Blaženka Grahovac and Nives Jonjić. "EGFR protein overexpression correlates with chromosome 7 polysomy and poor prognostic parameters in clear cell renal cell carcinoma." British Journal of Biomedical Science 19, no. 40 (2012): 1-8. https://doi.org/10.1186/1423-0127-19-40

Đorđević, G., et al. (2012) 'EGFR protein overexpression correlates with chromosome 7 polysomy and poor prognostic parameters in clear cell renal cell carcinoma', British Journal of Biomedical Science, 19(40), pp. 1-8. doi: 10.1186/1423-0127-19-40

Đorđević G, Matušan Ilijaš K, Hadžisejdić I, Maričić A, Grahovac B, Jonjić N. EGFR protein overexpression correlates with chromosome 7 polysomy and poor prognostic parameters in clear cell renal cell carcinoma. British Journal of Biomedical Science [Internet]. 2012 [cited 2024 December 20];19(40):1-8. doi: 10.1186/1423-0127-19-40

G. Đorđević, K. Matušan Ilijaš, I. Hadžisejdić, A. Maričić, B. Grahovac and N. Jonjić, "EGFR protein overexpression correlates with chromosome 7 polysomy and poor prognostic parameters in clear cell renal cell carcinoma", British Journal of Biomedical Science, vol. 19, no. 40, pp. 1-8, 2012. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:222934. [Accessed: 20 December 2024]

Metadata
Title (english)EGFR protein overexpression correlates with chromosome 7 polysomy and poor prognostic parameters in clear cell renal cell carcinoma
AuthorGordana Đorđević
AuthorKoviljka Matušan-Ilijaš
AuthorIta Hadžisejdić
AuthorAnton Maričić
AuthorBlaženka Grahovac
AuthorNives Jonjić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of General Pathology and Pathological Anatomy)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Urology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pathology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Urology
Abstract (english)
The role of epidermal growth factor (EGF) and its receptor (EGFR) in the pathogenesis and progression of various malignant tumors has long been known, but there is still disagreement concerning prognostic significance of EGFR expression in clear cell renal cell carcinoma (CCRCC). The present study was designed to analyze more objectively the protein EGFR expression in CCRCC and to compare its value with EGFR gene copy number changes and clinicopathologic characteristics including patient survival. The protein EGFR expression was analyzed immunohistochemically on 94 CCRCC, and gene copy number alterations of EGFR by FISH analysis on 41 CCRCC selected according to distinct membrane EGFR staining. Membrane EGFR expression in tumor cells was heterogeneous with respect to the proportion of positive cells and staining intensity. FISH analysis did not reveal EGFR gene amplification, while polysomy of chromosome 7 found in 41% was associated with higher EGFR membrane expression. Moreover, EGFR overexpression was associated with a higher nuclear grade, larger tumor size and shorter patient’s survival, while there was no connection with pathological stage. In conclusion, the protein expression of EGFR had an impact on prognosis in patients with CCRCC, while an increased copy number of chromosome 7 could be the possible reason for EGFR protein overexpression in the absence of gene amplification.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleBritish Journal of Biomedical Science
Numberingvol. 19, no. 40, pp. 1-8
p-ISSN0967-4845
DOIhttps://doi.org/10.1186/1423-0127-19-40
URN:NBNurn:nbn:hr:184:222934
Publication2012
Document URLhttp://bib.irb.hr/497994
Document URLhttp://www.jbiomedsci.com/content/19/1/40
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2018-05-21 06:30:54