prikaz prve stranice dokumenta Interstitial murine cytomegalovirus pneumonia after irradiation: characterization of cells that limit viral replication during established infection of the lungs
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Scientific paper - Original scientific paper
Interstitial murine cytomegalovirus pneumonia after irradiation: characterization of cells that limit viral replication during established infection of the lungs
Journal of Virology, 55 (1985), 2; 264-273. urn:nbn:hr:184:313984
Reddehase, MJ.; Weiland, F.; Münch, K.; Jonjić, Stipan; Lüske, A.; Koszinowski, UH.

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Reddehase, M., Weiland, F., Münch, K., Jonjić, S., Lüske, A. & Koszinowski, U. (1985). Interstitial murine cytomegalovirus pneumonia after irradiation: characterization of cells that limit viral replication during established infection of the lungs. Journal of Virology, 55. (2), 264-273. Retrieved from https://urn.nsk.hr/urn:nbn:hr:184:313984

Reddehase, MJ., et al. "Interstitial murine cytomegalovirus pneumonia after irradiation: characterization of cells that limit viral replication during established infection of the lungs." Journal of Virology, vol. 55, no. 2, 1985, pp. 264-273. https://urn.nsk.hr/urn:nbn:hr:184:313984

Reddehase, MJ., F. Weiland, K. Münch, Stipan Jonjić, A. Lüske and UH. Koszinowski. "Interstitial murine cytomegalovirus pneumonia after irradiation: characterization of cells that limit viral replication during established infection of the lungs." Journal of Virology 55, no. 2 (1985): 264-273. https://urn.nsk.hr/urn:nbn:hr:184:313984

Reddehase, M., et al. (1985) 'Interstitial murine cytomegalovirus pneumonia after irradiation: characterization of cells that limit viral replication during established infection of the lungs', Journal of Virology, 55(2), pp. 264-273. Available at: https://urn.nsk.hr/urn:nbn:hr:184:313984 (Accessed 14 May 2024)

Reddehase M, Weiland F, Münch K, Jonjić S, Lüske A, Koszinowski U. Interstitial murine cytomegalovirus pneumonia after irradiation: characterization of cells that limit viral replication during established infection of the lungs. Journal of Virology [Internet]. 1985 [cited 2024 May 14];55(2):264-273. Available at: https://urn.nsk.hr/urn:nbn:hr:184:313984

M. Reddehase, F. Weiland, K. Münch, S. Jonjić, A. Lüske and U. Koszinowski, "Interstitial murine cytomegalovirus pneumonia after irradiation: characterization of cells that limit viral replication during established infection of the lungs", Journal of Virology, vol. 55, no. 2, pp. 264-273, 1985. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:313984. [Accessed: 14 May 2024]

Metadata
Title (english)Interstitial murine cytomegalovirus pneumonia after irradiation: characterization of cells that limit viral replication during established infection of the lungs
AuthorMJ. Reddehase
AuthorF. Weiland
AuthorK. Münch
AuthorStipan Jonjić
AuthorA. Lüske
AuthorUH. Koszinowski
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Interstitial pneumonia associated with viral replication in lung tissue was observed after cytomegalovirus infection of total-body gamma-irradiated mice, whereas in noncompromised hosts the lungs were not affected and virus multiplication was restricted to the salivary glands. The radiation damage could either predispose normally nonpermissive cell types for productive infection or abrogate an immune control of the tissue manifestation of infection by elimination of lymphocytes. Adoptive transfer of lymphoid cells into irradiated, infected recipients supported the second alternative. Even when infection was established in the lungs, as manifested by the presence of infected lung tissue cells in the alveolar septa, an antiviral effect could be assigned to the Lyt-2+, L3T4- subset of T lymphocytes specifically sensitized in the immunocompetent donor. These cells did not require in vitro propagation to perform effector cell functions in vivo and were operative under physiological conditions in comparatively low numbers. Hence, there is reason to assume that T lymphocytes are responsible for the tissue distribution of cytomegalovirus replication during infection.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleJournal of Virology
Numberingvol. 55, no. 2, pp. 264-273
p-ISSN0022-538X
e-ISSN1098-5514
URN:NBNurn:nbn:hr:184:313984
Publication1985
Document URLhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC254929/pdf/jvirol00119-0018.pdf
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2018-07-30 10:15:18