prikaz prve stranice dokumenta Postoperative Regional Analgesia Is Effective in Preserving Perforin-Expressing Lymphocytes in Patients After Total Knee Replacement
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Scientific paper - Original scientific paper
Postoperative Regional Analgesia Is Effective in Preserving Perforin-Expressing Lymphocytes in Patients After Total Knee Replacement
Medical Science Monitor, 24 (2018); 5320-5328. https://doi.org/10.12659/MSM.909385
Velčić Brumnjak, Sandra; Rakovac, Ivan; Papež Kinkela, Dijana; Bukal, Krešimir; Šestan, Branko; Tulić, Vera; Velčić Janjetic, Elisa; Sotošek Tokmadžić, Vlatka

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Velčić Brumnjak, S., Rakovac, I., Papež Kinkela, D., Bukal, K., Šestan, B., Tulić, V. ... Sotošek Tokmadžić, V. (2018). Postoperative Regional Analgesia Is Effective in Preserving Perforin-Expressing Lymphocytes in Patients After Total Knee Replacement. Medical Science Monitor, 24., 5320-5328. doi: 10.12659/MSM.909385

Velčić Brumnjak, Sandra, et al. "Postoperative Regional Analgesia Is Effective in Preserving Perforin-Expressing Lymphocytes in Patients After Total Knee Replacement." Medical Science Monitor, vol. 24, 2018, pp. 5320-5328. https://doi.org/10.12659/MSM.909385

Velčić Brumnjak, Sandra, Ivan Rakovac, Dijana Papež Kinkela, Krešimir Bukal, Branko Šestan, Vera Tulić, Elisa Velčić Janjetic and Vlatka Sotošek Tokmadžić. "Postoperative Regional Analgesia Is Effective in Preserving Perforin-Expressing Lymphocytes in Patients After Total Knee Replacement." Medical Science Monitor 24 (2018): 5320-5328. https://doi.org/10.12659/MSM.909385

Velčić Brumnjak, S., et al. (2018) 'Postoperative Regional Analgesia Is Effective in Preserving Perforin-Expressing Lymphocytes in Patients After Total Knee Replacement', Medical Science Monitor, 24, pp. 5320-5328. doi: 10.12659/MSM.909385

Velčić Brumnjak S, Rakovac I, Papež Kinkela D, Bukal K, Šestan B, Tulić V, and sur.. Postoperative Regional Analgesia Is Effective in Preserving Perforin-Expressing Lymphocytes in Patients After Total Knee Replacement. Medical Science Monitor [Internet]. 2018 [cited 2024 November 30];24:5320-5328. doi: 10.12659/MSM.909385

S. Velčić Brumnjak, et al., "Postoperative Regional Analgesia Is Effective in Preserving Perforin-Expressing Lymphocytes in Patients After Total Knee Replacement", Medical Science Monitor, vol. 24, pp. 5320-5328, 2018. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:864748. [Accessed: 30 November 2024]

Metadata
Title (english)Postoperative Regional Analgesia Is Effective in Preserving Perforin-Expressing Lymphocytes in Patients After Total Knee Replacement
AuthorSandra Velčić Brumnjak
AuthorIvan Rakovac
AuthorDijana Papež Kinkela
AuthorKrešimir Bukal
AuthorBranko Šestan
AuthorVera Tulić
AuthorElisa Velčić Janjetic
AuthorVlatka Sotošek Tokmadžić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Anaesthesiology,reanimatology and Intensive Care)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Orthopedics and Physical Medicine)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Anesthesiology and Reanimatology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Orthopedics
Abstract (english)
Background: Pain and surgical stress cause a pro-inflammatory response followed by downregulation of the immune response, which can increase the incidence of postoperative complications, such as infections or prolonged wound healing. T lymphocytes and natural killer (NK) cells have cytotoxic potential and are crucial components of cellular immunity, which is important for maintenance of immune balance. The aim of this study was to analyze the effects of 3 types of postoperative analgesia on the preservation and cytotoxic potential of T lymphocytes, NK cells, and their subpopulations, as well as NKT cells, in patients after total knee replacement (TKR) to find the most effective analgesic technique for mitigating immune suppression. Material/Methods: Forty-eight patients scheduled for TKR were randomly allocated to Group 1 (patients received epidural analgesia), Group 2 (patients received sciatic and femoral nerve block), or Group 3 (patients received multimodal systemic analgesia). Pain intensity was assessed at rest and on movement before, immediately after, and at 24 and 72 h after surgery. Blood samples were collected at the same time points and peripheral blood mononuclear cells were isolated. The frequencies of T lymphocytes, NK cells, and NKT cells, as well as their perforin expression, were simultaneously detected and analyzed by flow cytometry. Results: Patients in Group 1 and Group 2 experienced less severe pain than those in Group 3. The frequencies and perforin levels of T lymphocytes, their subsets, and NKT cells were significantly lower in Group 3 than in Group 1 and Group 2. Conclusions: The present study confirmed that regional analgesia is more effective in maintaining cell-mediated immunity and perforin expression in peripheral blood lymphocytes in patients after TKR.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleMedical Science Monitor
Numberingvol. 24, pp. 5320-5328
e-ISSN1643-3750
DOIhttps://doi.org/10.12659/MSM.909385
URN:NBNurn:nbn:hr:184:864748
Publication2018
Document URLhttps://www.medscimonit.com/abstract/index/idArt/909385
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2018-08-06 10:50:38