prikaz prve stranice dokumenta Activation of the tumor suppressor p53 upon impairment of ribosome biogenesis
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Scientific paper - Review paper
Activation of the tumor suppressor p53 upon impairment of ribosome biogenesis
BBA - Biochimica et Biophysica Acta, 1842 (2014); 817-830. https://doi.org/10.1016/j.bbadis.2013.08.014
Bursać, Slađana; Cokarić Brdovčak, Maja; Donati, Giulio; Volarević, Siniša

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Bursać, S., Cokarić Brdovčak, M., Donati, G. & Volarević, S. (2014). Activation of the tumor suppressor p53 upon impairment of ribosome biogenesis. BBA - Biochimica et Biophysica Acta, 1842., 817-830. doi: 10.1016/j.bbadis.2013.08.014

Bursać, Slađana, et al. "Activation of the tumor suppressor p53 upon impairment of ribosome biogenesis." BBA - Biochimica et Biophysica Acta, vol. 1842, 2014, pp. 817-830. https://doi.org/10.1016/j.bbadis.2013.08.014

Bursać, Slađana, Maja Cokarić Brdovčak, Giulio Donati and Siniša Volarević. "Activation of the tumor suppressor p53 upon impairment of ribosome biogenesis." BBA - Biochimica et Biophysica Acta 1842 (2014): 817-830. https://doi.org/10.1016/j.bbadis.2013.08.014

Bursać, S., et al. (2014) 'Activation of the tumor suppressor p53 upon impairment of ribosome biogenesis', BBA - Biochimica et Biophysica Acta, 1842, pp. 817-830. doi: 10.1016/j.bbadis.2013.08.014

Bursać S, Cokarić Brdovčak M, Donati G, Volarević S. Activation of the tumor suppressor p53 upon impairment of ribosome biogenesis. BBA - Biochimica et Biophysica Acta [Internet]. 2014 [cited 2024 November 27];1842:817-830. doi: 10.1016/j.bbadis.2013.08.014

S. Bursać, M. Cokarić Brdovčak, G. Donati and S. Volarević, "Activation of the tumor suppressor p53 upon impairment of ribosome biogenesis", BBA - Biochimica et Biophysica Acta, vol. 1842, pp. 817-830, 2014. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:017875. [Accessed: 27 November 2024]

Metadata
Title (english)Activation of the tumor suppressor p53 upon impairment of ribosome biogenesis
AuthorSlađana Bursać
AuthorMaja Cokarić Brdovčak
AuthorGiulio Donati
AuthorSiniša Volarević
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Molecular Medicine and Biotechnology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Human Genetics, Genomics and Proteomics
Abstract (english)
Errors in ribosome biogenesis can result in quantitative or qualitative defects in protein synthesis and conse- quently lead to improper execution of the genetic program and the development of speci fi c diseases. Evidence has accumulated over the last decade suggesting that perturbation of ribosome biogenesis triggers a p53- activating checkpointsignaling pathway,often referred to as the ribosome biogenesis stress checkpoint pathway. Although it was originally suggested that p53 has a pro minent role in preventing diseases by monitoring the fi delity of ribosome biogenesis, recent work has demonstrated that p53 activation upon impairment of ribosome biogenesis also mediates pathological manifestations in humans . Perturbations of ribosome biogenesis can trigger a p53-dependent checkpoint signaling pathway independent of DNA damage and the tumor suppressor ARF through inhibitory interactions of speci fi c ribosomal components with the p53 negative regulator, Mdm2. Here we review the recent advances made toward understanding of this newly-recognized checkpoint signaling pathway, its role in health and disease, and discuss possible future directions in this exciting research fi eld. This article is part of a Special Issue entitled: Role of the Nucleolus in Human Disease.
Keywords (english)
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleBBA - Biochimica et Biophysica Acta
Numberingvol. 1842, pp. 817-830
p-ISSN0006-3002
DOIhttps://doi.org/10.1016/j.bbadis.2013.08.014
URN:NBNurn:nbn:hr:184:017875
Publication2014
ProjectNumber: 223151
Title (english): Understanding inflammation-associated tumorigenesis for the rational design of novel anti-cancer therapeutic strategies.
Acronym: INFLA-CARE
Jurisdiction: eu
Funding stream: FP7
Document URLhttps://doi.org/10.1016/j.bbadis.2013.08.014
Type of resourceText
Access conditionsInstitutional access
Terms of useLicence In copyright icon
Created on2018-10-14 18:36:28