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Scientific paper - Review paper
MCMV avoidance of recognition and control by NK cells
Seminars in Immunopathology, 36 (2014), 6; 641-650. https://doi.org/10.1007/s00281-014-0441-9
Brizić, Ilija; Lenac Roviš, Tihana; Krmpotić, Astrid; Jonjić, Stipan

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Brizić, I., Lenac Roviš, T., Krmpotić, A. & Jonjić, S. (2014). MCMV avoidance of recognition and control by NK cells. Seminars in Immunopathology, 36. (6), 641-650. doi: 10.1007/s00281-014-0441-9

Brizić, Ilija, et al. "MCMV avoidance of recognition and control by NK cells." Seminars in Immunopathology, vol. 36, no. 6, 2014, pp. 641-650. https://doi.org/10.1007/s00281-014-0441-9

Brizić, Ilija, Tihana Lenac Roviš, Astrid Krmpotić and Stipan Jonjić. "MCMV avoidance of recognition and control by NK cells." Seminars in Immunopathology 36, no. 6 (2014): 641-650. https://doi.org/10.1007/s00281-014-0441-9

Brizić, I., et al. (2014) 'MCMV avoidance of recognition and control by NK cells', Seminars in Immunopathology, 36(6), pp. 641-650. doi: 10.1007/s00281-014-0441-9

Brizić I, Lenac Roviš T, Krmpotić A, Jonjić S. MCMV avoidance of recognition and control by NK cells. Seminars in Immunopathology [Internet]. 2014 August 21 [cited 2024 November 23];36(6):641-650. doi: 10.1007/s00281-014-0441-9

I. Brizić, T. Lenac Roviš, A. Krmpotić and S. Jonjić, "MCMV avoidance of recognition and control by NK cells", Seminars in Immunopathology, vol. 36, no. 6, pp. 641-650, August 2014. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:853548. [Accessed: 23 November 2024]

Metadata
Title (english)MCMV avoidance of recognition and control by NK cells
AuthorIlija Brizić
AuthorTihana Lenac Roviš
AuthorAstrid Krmpotić
AuthorStipan Jonjić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Center for Proteomics)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Natural killer (NK) cells play an important role in virus control during infection. Many viruses have developed mechanisms for subversion of NK cell responses. Murine cytomegalovirus (MCMV) is exceptionally successful in avoiding NK cell control. Here, we summarize the major MCMV evasion mechanisms targeting NK cell functions and their role in viral pathogenesis. The mechanisms by which NK cells regulate CD8+ T cell response, particularly with respect to the role of NK cell receptors recognizing viral antigens, are discussed. In addition, we discuss the role of NK cell receptors in generation and maintenance of memory NK cells. Final part of this review illustrates how the NK cell response and its viral regulation can be exploited in designing recombinant viral vectors able to induce robust and protective CD8+ T cell response.
Keywords (english)
Languageenglish
Publication typeScientific paper - Review paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleSeminars in Immunopathology
Numberingvol. 36, no. 6, pp. 641-650
p-ISSN1863-2297
e-ISSN1863-2300
DOIhttps://doi.org/10.1007/s00281-014-0441-9
URN:NBNurn:nbn:hr:184:853548
Publication2014-08-21
Publication2014-11
ProjectNumber: 322693
Title (croatian): Strengthening adaptive immunity via innate immunity: enhancing the CD8 T cell response by using the NKG2D ligand expressed in a herpesvirus vector
Acronym: STADVINN
Jurisdiction: eu
Funding stream: FP7
Document URLhttp://link.springer.com/10.1007/s00281-014-0441-9
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2018-10-31 09:39:07