prikaz prve stranice dokumenta BPTF inhibits NK cell activity and the abundance of natural cytotoxicity receptor co-ligands
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Scientific paper - Original scientific paper
BPTF inhibits NK cell activity and the abundance of natural cytotoxicity receptor co-ligands
Oncotarget, 8 (2017), 38; 643447-64357. https://doi.org/10.18632/oncotarget.17834
Mayes, Kimberly; Elsayed, Zeinab; Alhazmi, Aiman; Waters, Michael; Alkhatib, Suehyb G.; Roberts, Mark; Song, Carolyn; Peterson, Kristen; Chan, Vivian; Ailaney, Nikhil; Malapati, Pumoli; Blevins, Tana; Lisnić, Berislav; Dumur, Catherine I.; Landry, Joseph W. More authors...

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Mayes, K., Elsayed, Z., Alhazmi, A., Waters, M., Alkhatib, S. G., Roberts, M. ... Landry, J. W. (2017). BPTF inhibits NK cell activity and the abundance of natural cytotoxicity receptor co-ligands. Oncotarget, 8. (38), 643447-64357. doi: 10.18632/oncotarget.17834

Mayes, Kimberly, et al. "BPTF inhibits NK cell activity and the abundance of natural cytotoxicity receptor co-ligands." Oncotarget, vol. 8, no. 38, 2017, pp. 643447-64357. https://doi.org/10.18632/oncotarget.17834

Mayes, Kimberly, Zeinab Elsayed, Aiman Alhazmi, Michael Waters, Suehyb G. Alkhatib, Mark Roberts, Carolyn Song, et al. "BPTF inhibits NK cell activity and the abundance of natural cytotoxicity receptor co-ligands." Oncotarget 8, no. 38 (2017): 643447-64357. https://doi.org/10.18632/oncotarget.17834

Mayes, K., et al. (2017) 'BPTF inhibits NK cell activity and the abundance of natural cytotoxicity receptor co-ligands', Oncotarget, 8(38), pp. 643447-64357. doi: 10.18632/oncotarget.17834

Mayes K, Elsayed Z, Alhazmi A, Waters M, Alkhatib SG, Roberts M, and sur.. BPTF inhibits NK cell activity and the abundance of natural cytotoxicity receptor co-ligands. Oncotarget [Internet]. 2017 September 06 [cited 2024 August 26];8(38):643447-64357. doi: 10.18632/oncotarget.17834

K. Mayes, et al., "BPTF inhibits NK cell activity and the abundance of natural cytotoxicity receptor co-ligands", Oncotarget, vol. 8, no. 38, pp. 643447-64357, September 2017. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:393775. [Accessed: 26 August 2024]

Metadata
Title (english)BPTF inhibits NK cell activity and the abundance of natural cytotoxicity receptor co-ligands
AuthorKimberly Mayes
AuthorZeinab Elsayed
AuthorAiman Alhazmi
AuthorMichael Waters
AuthorSuehyb G. Alkhatib
AuthorMark Roberts
AuthorCarolyn Song
AuthorKristen Peterson
AuthorVivian Chan
AuthorNikhil Ailaney
AuthorPumoli Malapati
AuthorTana Blevins
AuthorBerislav Lisnić
AuthorCatherine I. Dumur
AuthorJoseph W. Landry
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Center for Proteomics)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Using syngeneic BALB/c mouse breast cancer models, we show that the chromatin remodeling subunit bromodomain PHD finger transcription factor (BPTF) suppresses natural killer (NK) cell antitumor activity in the tumor microenvironment (TME). In culture, BPTF suppresses direct natural cytotoxicity receptor (NCR) mediated NK cell cytolytic activity to mouse and human cancer cell lines, demonstrating conserved functions. Blocking mouse NCR1 in vivo rescues BPTF KD tumor weights, demonstrating its importance for the control of tumor growth. We discovered that BPTF occupies heparanase (Hpse) regulatory elements, activating its expression. Increased heparanase activity results in reduced cell surface abundance of the NCR co-ligands: heparan sulfate proteoglycans (HSPGs). Using gain and loss of function approaches we show that elevated heparanase levels suppress NK cell cytolytic activity to tumor cells in culture. These results suggest that BPTF activates heparanase expression, which in turn reduces cell surface HSPGs and NCR co-ligands, inhibiting NK cell activity. Furthermore, gene expression data from human breast cancer tumors shows that elevated BPTF expression correlates with reduced antitumor immune cell signatures, supporting conserved roles for BPTF in suppressing antitumor immunity. Conditional BPTF depletion in established mouse breast tumors enhances antitumor immunity, suggesting that inhibiting BPTF could provide a novel immunotherapy.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleOncotarget
Numberingvol. 8, no. 38, pp. 643447-64357
e-ISSN1949-2553
DOIhttps://doi.org/10.18632/oncotarget.17834
URN:NBNurn:nbn:hr:184:393775
Publication2017-09-06
Publication2017-09-08
Document URLhttp://www.oncotarget.com/fulltext/17834
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution 3.0 Unported (CC BY 3.0) icon
Created on2018-11-02 08:18:25