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Scientific paper - Original scientific paper
CEACAM1-Mediated Inhibition of Virus Production
Cell Reports, 15 (2016), 11; 2331-2339. https://doi.org/10.1016/j.celrep.2016.05.036
Vitenshtein, Alon; Weisblum, Yiska; Hauka, Sebastian; Halenius, Anne; Oiknine-Djian, Esther; Tsukerman, Pinchas; Bauman, Yoav; Bar-On, Yotam; Stern-Ginossar, Noam; Enk, Jonatan; Ortenberg, Rona; Tai, Julie; Markel, Gal; Blumberg, Richard S.; Hengel, Hartmut; Jonjić, Stipan; Wolf, Dana G.; Adler, Heiko; Kammerer, Robert; Mandelboim, Ofer More authors...

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Vitenshtein, A., Weisblum, Y., Hauka, S., Halenius, A., Oiknine Djian, E., Tsukerman, P. ... Mandelboim, O. (2016). CEACAM1-Mediated Inhibition of Virus Production. Cell Reports, 15. (11), 2331-2339. doi: 10.1016/j.celrep.2016.05.036

Vitenshtein, Alon, et al. "CEACAM1-Mediated Inhibition of Virus Production." Cell Reports, vol. 15, no. 11, 2016, pp. 2331-2339. https://doi.org/10.1016/j.celrep.2016.05.036

Vitenshtein, Alon, Yiska Weisblum, Sebastian Hauka, Anne Halenius, Esther Oiknine Djian, Pinchas Tsukerman, Yoav Bauman, et al. "CEACAM1-Mediated Inhibition of Virus Production." Cell Reports 15, no. 11 (2016): 2331-2339. https://doi.org/10.1016/j.celrep.2016.05.036

Vitenshtein, A., et al. (2016) 'CEACAM1-Mediated Inhibition of Virus Production', Cell Reports, 15(11), pp. 2331-2339. doi: 10.1016/j.celrep.2016.05.036

Vitenshtein A, Weisblum Y, Hauka S, Halenius A, Oiknine Djian E, Tsukerman P, and sur.. CEACAM1-Mediated Inhibition of Virus Production. Cell Reports [Internet]. 2016 June [cited 2024 May 14];15(11):2331-2339. doi: 10.1016/j.celrep.2016.05.036

A. Vitenshtein, et al., "CEACAM1-Mediated Inhibition of Virus Production", Cell Reports, vol. 15, no. 11, pp. 2331-2339, June 2016. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:008420. [Accessed: 14 May 2024]

Metadata
Title (english)CEACAM1-Mediated Inhibition of Virus Production
AuthorAlon Vitenshtein
AuthorYiska Weisblum
AuthorSebastian Hauka
AuthorAnne Halenius
AuthorEsther Oiknine-Djian
AuthorPinchas Tsukerman
AuthorYoav Bauman
AuthorYotam Bar-On
AuthorNoam Stern-Ginossar
AuthorJonatan Enk
AuthorRona Ortenberg
AuthorJulie Tai
AuthorGal Markel
AuthorRichard S. Blumberg
AuthorHartmut Hengel
AuthorStipan Jonjić
AuthorDana G. Wolf
AuthorHeiko Adler
AuthorRobert Kammerer
AuthorOfer Mandelboim
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Center for Proteomics)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Cells in our body can induce hundreds of antiviral genes following virus sensing, many of which remain largely uncharacterized. CEACAM1 has been previously shown to be induced by various innate systems; however, the reason for such tight integration to innate sensing systems was not apparent. Here, we show that CEACAM1 is induced following detection of HCMV and influenza viruses by their respective DNA and RNA innate sensors, IFI16 and RIG-I. This induction is mediated by IRF3, which bound to an ISRE element present in the human, but not mouse, CEACAM1 promoter. Furthermore, we demonstrate that, upon induction, CEACAM1 suppresses both HCMV and influenza viruses in an SHP2-dependent process and achieves this broad antiviral efficacy by suppressing mTOR-mediated protein biosynthesis. Finally, we show that CEACAM1 also inhibits viral spread in ex vivo human decidua organ culture.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleCell Reports
Numberingvol. 15, no. 11, pp. 2331-2339
p-ISSN2211-1247
DOIhttps://doi.org/10.1016/j.celrep.2016.05.036
URN:NBNurn:nbn:hr:184:008420
Publication2016-06
ProjectNumber: 320473
Title (english): Recognition of bacteria by NK cells
Acronym: BACNK
Jurisdiction: eu
Funding stream: FP7
ProjectNumber: 316655
Title (english): Training network for next generation vaccinologists
Acronym: VACTRAIN
Jurisdiction: eu
Funding stream: FP7
ProjectNumber: 062-0621261-1263
Title (croatian): Molekularni mehanizmi citomegalovirusnog izmicanja imunološkom nadzoru
Leader: Stipan Jonjić
Jurisdiction: Croatia
Funding stream: ZP
Document URLhttps://linkinghub.elsevier.com/retrieve/pii/S2211124716306192
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2018-11-07 09:25:55