prikaz prve stranice dokumenta Viral Inhibition of BAK Promotes Murine Cytomegalovirus Dissemination to Salivary Glands
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Scientific paper - Original scientific paper
Viral Inhibition of BAK Promotes Murine Cytomegalovirus Dissemination to Salivary Glands
Journal of Virology, 87 (2013), 6; 3592-3596. https://doi.org/10.1128/JVI.02657-12
Handke, W.; Luig, C.; Popović, Branka; Krmpotić, Astrid; Jonjić, Stipan; Brune, Wolfram

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Handke, W., Luig, C., Popović, B., Krmpotić, A., Jonjić, S. & Brune, W. (2013). Viral Inhibition of BAK Promotes Murine Cytomegalovirus Dissemination to Salivary Glands. Journal of Virology, 87. (6), 3592-3596. doi: 10.1128/JVI.02657-12

Handke, W., et al. "Viral Inhibition of BAK Promotes Murine Cytomegalovirus Dissemination to Salivary Glands." Journal of Virology, vol. 87, no. 6, 2013, pp. 3592-3596. https://doi.org/10.1128/JVI.02657-12

Handke, W., C. Luig, Branka Popović, Astrid Krmpotić, Stipan Jonjić and Wolfram Brune. "Viral Inhibition of BAK Promotes Murine Cytomegalovirus Dissemination to Salivary Glands." Journal of Virology 87, no. 6 (2013): 3592-3596. https://doi.org/10.1128/JVI.02657-12

Handke, W., et al. (2013) 'Viral Inhibition of BAK Promotes Murine Cytomegalovirus Dissemination to Salivary Glands', Journal of Virology, 87(6), pp. 3592-3596. doi: 10.1128/JVI.02657-12

Handke W, Luig C, Popović B, Krmpotić A, Jonjić S, Brune W. Viral Inhibition of BAK Promotes Murine Cytomegalovirus Dissemination to Salivary Glands. Journal of Virology [Internet]. 2013 January 09 [cited 2024 December 26];87(6):3592-3596. doi: 10.1128/JVI.02657-12

W. Handke, C. Luig, B. Popović, A. Krmpotić, S. Jonjić and W. Brune, "Viral Inhibition of BAK Promotes Murine Cytomegalovirus Dissemination to Salivary Glands", Journal of Virology, vol. 87, no. 6, pp. 3592-3596, January 2013. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:801946. [Accessed: 26 December 2024]

Metadata
Title (english)Viral Inhibition of BAK Promotes Murine Cytomegalovirus Dissemination to Salivary Glands
AuthorW. Handke
AuthorC. Luig
AuthorBranka Popović
AuthorAstrid Krmpotić
AuthorStipan Jonjić
AuthorWolfram Brune
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Apoptosis induction is an important host defense mechanism to control viral infection, which is antagonized by viral proteins. Murine cytomegalovirus m41.1 encodes a viral inhibitor of BAK oligomerization (vIBO) that blocks the mitochondrial apoptosis mediator BAK. However, its importance for viral fitness in vivo has not been investigated. Here, we show that an m41.1-deficient virus attains reduced titers in salivary glands of wild-type but not Bak1(-/-) mice, indicating a requirement of BAK inhibition for optimal dissemination in vivo.
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleJournal of Virology
Numberingvol. 87, no. 6, pp. 3592-3596
p-ISSN0022-538X
DOIhttps://doi.org/10.1128/JVI.02657-12
URN:NBNurn:nbn:hr:184:801946
Publication2013-01-09
Publication2013-03-15
Document URLhttp://jvi.asm.org/cgi/doi/10.1128/JVI.02657-12
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2018-11-08 10:43:25