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Scientific paper - Original scientific paper
The NK Cell Response to Mouse Cytomegalovirus Infection Affects the Level and Kinetics of the Early CD8+ T-Cell Response
Journal of Virology, 86 (2012), 4; 2165-2175. https://doi.org/10.1128/JVI.06042-11
Mitrović, Maja; Arapović, Jurica; Jordan, Stefan; Fodil-Cornu, N.; Ebert, S.; Vidal, S. M.; Krmpotić, Astrid; Reddehase, M. J.; Jonjić, Stipan

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Mitrović, M., Arapović, J., Jordan, S., Fodil Cornu, N., Ebert, S., Vidal, S. M. ... Jonjić, S. (2012). The NK Cell Response to Mouse Cytomegalovirus Infection Affects the Level and Kinetics of the Early CD8+ T-Cell Response. Journal of Virology, 86. (4), 2165-2175. doi: 10.1128/JVI.06042-11

Mitrović, Maja, et al. "The NK Cell Response to Mouse Cytomegalovirus Infection Affects the Level and Kinetics of the Early CD8+ T-Cell Response." Journal of Virology, vol. 86, no. 4, 2012, pp. 2165-2175. https://doi.org/10.1128/JVI.06042-11

Mitrović, Maja, Jurica Arapović, Stefan Jordan, N. Fodil Cornu, S. Ebert, S. M. Vidal, Astrid Krmpotić, M. J. Reddehase and Stipan Jonjić. "The NK Cell Response to Mouse Cytomegalovirus Infection Affects the Level and Kinetics of the Early CD8+ T-Cell Response." Journal of Virology 86, no. 4 (2012): 2165-2175. https://doi.org/10.1128/JVI.06042-11

Mitrović, M., et al. (2012) 'The NK Cell Response to Mouse Cytomegalovirus Infection Affects the Level and Kinetics of the Early CD8+ T-Cell Response', Journal of Virology, 86(4), pp. 2165-2175. doi: 10.1128/JVI.06042-11

Mitrović M, Arapović J, Jordan S, Fodil Cornu N, Ebert S, Vidal SM, and sur.. The NK Cell Response to Mouse Cytomegalovirus Infection Affects the Level and Kinetics of the Early CD8+ T-Cell Response. Journal of Virology [Internet]. 2012 December 07 [cited 2024 December 24];86(4):2165-2175. doi: 10.1128/JVI.06042-11

M. Mitrović, et al., "The NK Cell Response to Mouse Cytomegalovirus Infection Affects the Level and Kinetics of the Early CD8+ T-Cell Response", Journal of Virology, vol. 86, no. 4, pp. 2165-2175, December 2012. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:713679. [Accessed: 24 December 2024]

Metadata
Title (english)The NK Cell Response to Mouse Cytomegalovirus Infection Affects the Level and Kinetics of the Early CD8+ T-Cell Response
AuthorMaja Mitrović
AuthorJurica Arapović
AuthorStefan Jordan
AuthorN. Fodil-Cornu
AuthorS. Ebert
AuthorS. M. Vidal
AuthorAstrid Krmpotić
AuthorM. J. Reddehase
AuthorStipan Jonjić
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Histology and Embryology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Basic Medical Sciences
Abstract (english)
Natural killer (NK) cells and CD8+ T cells play a prominent role in the clearance of mouse cytomegalovirus (MCMV) infection. The role of NK cells in modulating the CD8+ T-cell response to MCMV infection is still the subject of intensive research. For analyzing the impact of NK cells on mounting of a CD8+ T-cell response and the contribution of these cells to virus control during the first days postinfection (p.i.), we used C57BL/6 mice in which NK cells are specifically activated through the Ly49H receptor engaged by the MCMV-encoded ligand m157. Our results indicate that the requirement for CD8+ T cells in early MCMV control inversely correlates with the engagement of Ly49H. While depletion of CD8+ T cells has only a minor effect on the early control of wild-type MCMV, CD8+ T cells are essential in the control of Δm157 virus. The frequencies of virus epitope-specific CD8+ T cells and their activation status were higher in mice infected with Δm157 virus. In addition, these mice showed elevated levels of alpha interferon (IFN-α) and several other proinflammatory cytokines as early as 1.5 days p.i. Although the numbers of conventional dendritic cells (cDCs) were reduced later during infection, particularly in Δm157-infected mice, they were not significantly affected at the peak of the cytokine response. Altogether, we concluded that increased antigen load, preservation of early cDCs' function, and higher levels of innate cytokines collectively account for an enhanced CD8+ T-cell response in C57BL/6 mice infected with a virus unable to activate NK cells via the Ly49H–m157 interaction.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titleJournal of Virology
Numberingvol. 86, no. 4, pp. 2165-2175
p-ISSN0022-538X
DOIhttps://doi.org/10.1128/JVI.06042-11
URN:NBNurn:nbn:hr:184:713679
Publication2012-12-07
Publication2012-02-15
ProjectNumber: 062-0621261-1263
Title (croatian): Molekularni mehanizmi citomegalovirusnog izmicanja imunološkom nadzoru
Leader: Stipan Jonjić
Jurisdiction: Croatia
Funding stream: ZP
ProjectNumber: 062-0621261-1268
Title (croatian): Uloga imunosubverzivnih citomegalovirusnih gena u latenciji
Leader: Astrid Krmpotić
Jurisdiction: Croatia
Funding stream: ZP
Document URLhttp://jvi.asm.org/cgi/doi/10.1128/JVI.06042-11
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2018-11-08 11:14:53