prikaz prve stranice dokumenta Matrix Metalloproteinases 2 and 9 Immunoexpression in Prostate Carcinoma at the Positive Margin of Radical Prostatectomy Specimens
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Scientific paper - Original scientific paper
Matrix Metalloproteinases 2 and 9 Immunoexpression in Prostate Carcinoma at the Positive Margin of Radical Prostatectomy Specimens
Pathology Research International, 2014 (2014); 1-8. https://doi.org/10.1155/2014/262195
Oguić, Romano; Mozetič, Vladimir; Cini Tešar, Eleonora; Fučkar Čupić, Dora; Mustać, Elvira; Đorđević, Gordana

Institutional repository: Repository of the University of Rijeka, Faculty of Medicine

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Oguić, R., Mozetič, V., Cini Tešar, E., Fučkar Čupić, D., Mustać, E. & Đorđević, G. (2014). Matrix Metalloproteinases 2 and 9 Immunoexpression in Prostate Carcinoma at the Positive Margin of Radical Prostatectomy Specimens. Pathology Research International, 2014., 1-8. doi: 10.1155/2014/262195

Oguić, Romano, et al. "Matrix Metalloproteinases 2 and 9 Immunoexpression in Prostate Carcinoma at the Positive Margin of Radical Prostatectomy Specimens." Pathology Research International, vol. 2014, 2014, pp. 1-8. https://doi.org/10.1155/2014/262195

Oguić, Romano, Vladimir Mozetič, Eleonora Cini Tešar, Dora Fučkar Čupić, Elvira Mustać and Gordana Đorđević. "Matrix Metalloproteinases 2 and 9 Immunoexpression in Prostate Carcinoma at the Positive Margin of Radical Prostatectomy Specimens." Pathology Research International 2014 (2014): 1-8. https://doi.org/10.1155/2014/262195

Oguić, R., et al. (2014) 'Matrix Metalloproteinases 2 and 9 Immunoexpression in Prostate Carcinoma at the Positive Margin of Radical Prostatectomy Specimens', Pathology Research International, 2014, pp. 1-8. doi: 10.1155/2014/262195

Oguić R, Mozetič V, Cini Tešar E, Fučkar Čupić D, Mustać E, Đorđević G. Matrix Metalloproteinases 2 and 9 Immunoexpression in Prostate Carcinoma at the Positive Margin of Radical Prostatectomy Specimens. Pathology Research International [Internet]. 2014 July 06 [cited 2024 November 30];2014:1-8. doi: 10.1155/2014/262195

R. Oguić, V. Mozetič, E. Cini Tešar, D. Fučkar Čupić, E. Mustać and G. Đorđević, "Matrix Metalloproteinases 2 and 9 Immunoexpression in Prostate Carcinoma at the Positive Margin of Radical Prostatectomy Specimens", Pathology Research International, vol. 2014, pp. 1-8, July 2014. [Online]. Available at: https://urn.nsk.hr/urn:nbn:hr:184:023922. [Accessed: 30 November 2024]

Metadata
Title (english)Matrix Metalloproteinases 2 and 9 Immunoexpression in Prostate Carcinoma at the Positive Margin of Radical Prostatectomy Specimens
AuthorRomano Oguić
AuthorVladimir Mozetič
AuthorEleonora Cini Tešar
AuthorDora Fučkar Čupić
AuthorElvira Mustać
AuthorGordana Đorđević
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Oncology and Radiotherapy)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of General Pathology and Pathological Anatomy)
Author's institutionUniversity of Rijeka
Faculty of Medicine
(Department of Urology)
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Urology
Scientific / art field,
discipline and subdiscipline		BIOMEDICINE AND HEALTHCARE
Clinical Medical Sciences
Pathology
Abstract (english)
The aim of this study was to evaluate the expression of matrix metalloproteinase 2 (MMP-2) and matrix metalloproteinase 9 (MMP-9) in prostate cancer in the main tumor mass and tumor cells at the positive margin as well as the influence of these biomarkers on the biochemical recurrence of the disease in prostatectomy patients. Tissue microarrays of 120 archival prostate carcinoma samples were immunohistochemically evaluated for MMP-2 and MMP-9 expression and compared with clinicopathological parameters. Tumors with positive surgical margins showed significantly higher overall expression of MMP-9 versus tumors with negative resection margins . MMP-9 expression was significantly elevated in tumors from patients who had biochemical recurrence . In the group of patients with negative margins, MMP-9 expression above the cut-off value was significantly associated with recurrence . Multivariate analysis indicated that MMP-9 is a good predictor of biochemical recurrence (odds ratio = 10.29; ). Expression of MMP-2 in tumor cells was significantly higher at the positive margins than in the main tumor mass . The present results highlight the potential value of MMP-2 and MMP-9 expression for predicting the behavior of prostate tumors after prostatectomy with both positive and negative surgical margins.
Keywords (english)
Languageenglish
Publication typeScientific paper - Original scientific paper
Publication statusPublished
Peer reviewPeer review - international
Publication versionPublished version
Journal titlePathology Research International
Numberingvol. 2014, pp. 1-8
p-ISSN2090-8091
e-ISSN2042-003X
DOIhttps://doi.org/10.1155/2014/262195
URN:NBNurn:nbn:hr:184:023922
Publication2014-07-06
ProjectNumber: 062-0620095-0077
Title (croatian): Molekularni mehanizmi tumorske progresije i metastaziranja raka dojke i prostate
Leader: Elvira Mustać
Jurisdiction: Croatia
Funding stream: ZP
Document URLhttps://www.hindawi.com/archive/2014/262195/
Type of resourceText
Access conditionsOpen access
Terms of useLicence Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) icon
Created on2018-11-13 15:56:05