INTRODUCTION: Contemporary antiepileptic drugs are effective in about 70% of children, but side effects limit their use. Therefore, it is a very important choice of antiepileptic drug that will outweigh the risk of side effects with its effectiveness. PURPOSE: Examine how many side effects are in children using antiepileptic drugs, which organic systems are affected by side effects and whether there is a difference between the occurrence of side effects in patients on monotherapy and polytherapy. TESTS AND PROCEDURES: Subjects with epilepsy diagnosis who are using AED for at least six months were monitored between 2010 and 2017. Data on the application of specific AED were analyzed, and whether the subject was using a monotherapy or AEL polytherapy. Side effects were analyzed using available medical documentation and divided according to the MedDRA classification system. The data were analyzed in the Excel document. A Chi-quadrat test was used to compare the occurrence of AEL side effects on monotherapy and polytherapy. RESULTS: Of the total number of respondents, 25% had side effects. The highest number of subjects were lamotrigine, levetiracetam and oxcarbazepine. Registered side effects have affected the nervous system and caused psychiatric disorders in the majority of subjects. Other side effects included rash, nausea, vomiting, dizziness, nausea, vomiting, weight gain and thrombocytopenia . CONCLUSION: From the above results we conclude that a quarter of children using AEL had side effects, especially those affecting the nervous system and behavioral changes. We have confirmed the benefits of polytherapy over monotherapy, and we believe we should insist on AED monotherapy whenever is possible to reduce the risk of side effects. There is also a need for more research of the action of medicines in the pediatric population due to their physiological and pharmacological differences from the adult population.