Mechanical ventilation is often used as a form of supportive treatment in modern intensive care unit (ICU). It carries a number of risks and complications, so it is of great importance to early start with weaning from mechanical ventilation (if the patient's condition so permits). This study involved a total of 172 patients requiring mechanical ventilation support for more than 24 hours during the period from 01 January to 01 July 2016. The purpose of this study was to analyze (from the existing medical documentation) the patient's characteristics and the outcomes of mechanical ventilation. The average age of the patient was 66,16 years. The most common reasons for ventilation were sepsis, pulmonary diseases, severe injuries, and postoperative discontinuation. Tracheostomy was performed in 36,63% of patients. The reintubation rate was 31,11%, and the ICU mortality rate was 31%. 70% of the patients were in the group of simple weaning, 25% in the difficult to wean group, and 5% in the group of prolonged weaning. Based on ventilation outcomes patients were divided into: successfully extubated (33%), extubated with death within 24 hours (2%), decanylated (2%), weaned with spontaneous respiration via tracheal cannula (30 %) or orotracheal tube (1%) and those who died without weaning attempts (28%) Simple weaning is expected in over 60% of patients, while difficult and prolonged weaning is expected in about 30% of the patients. Performing tracheostomy as well as using NIV may be useful in discontinuation of ventilatory support. The need for creating weaning protocols (and sedation protocols) is emphasized.